ID B7PF92_IXOSC Unreviewed; 200 AA.
AC B7PF92;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Cysteine synthase, putative {ECO:0000313|EMBL:EEC05264.1, ECO:0000313|EnsemblMetazoa:ISCW003755-PA};
DE EC=4.2.1.22 {ECO:0000313|EMBL:EEC05264.1};
GN ORFNames=IscW_ISCW003755 {ECO:0000313|EMBL:EEC05264.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC05264.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC05264.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW003755-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW003755-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine
CC from L-homocysteine and L-serine: step 1/2.
CC {ECO:0000256|ARBA:ARBA00005003}.
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DR EMBL; ABJB010239474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010506437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS700554; EEC05264.1; -; Genomic_DNA.
DR RefSeq; XP_002433864.1; XM_002433819.1.
DR AlphaFoldDB; B7PF92; -.
DR STRING; 6945.B7PF92; -.
DR PaxDb; 6945-B7PF92; -.
DR EnsemblMetazoa; ISCW003755-RA; ISCW003755-PA; ISCW003755.
DR KEGG; isc:IscW_ISCW003755; -.
DR VEuPathDB; VectorBase:ISCI003755; -.
DR VEuPathDB; VectorBase:ISCP_012897; -.
DR VEuPathDB; VectorBase:ISCW003755; -.
DR HOGENOM; CLU_1367570_0_0_1; -.
DR InParanoid; B7PF92; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004122; F:cystathionine beta-synthase activity; IBA:GO_Central.
DR GO; GO:0006535; P:cysteine biosynthetic process from serine; IBA:GO_Central.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR001216; P-phosphate_BS.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR PANTHER; PTHR10314; CYSTATHIONINE BETA-SYNTHASE; 1.
DR PANTHER; PTHR10314:SF194; CYSTATHIONINE BETA-SYNTHASE; 1.
DR Pfam; PF00291; PALP; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 2.
DR PROSITE; PS00901; CYS_SYNTHASE; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023192};
KW Cysteine biosynthesis {ECO:0000256|ARBA:ARBA00023192};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:EEC05264.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 16..86
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
SQ SEQUENCE 200 AA; 21940 MW; D4E0430F9446AD85 CRC64;
MFVSRGPKAK IFPDILAHVG DTPMVRINKI NKEYGVECEL LAKCEFFNPG GSIKDRIGLR
MVQEAERDGI LRPGSVIIEP TSGNTGEYPN FFASGSSGAA MSVAVHAAKS LKPGQKCVVV
LPDGVRNYMT KFLSDTWMVE RGFMDLSSEM SSKHWWWNQT VRSLKLCIPL TLLPSVTCQE
AIELMSAESI DQVPVVDASG
//
