ID B7PFM3_IXOSC Unreviewed; 654 AA.
AC B7PFM3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Aminopeptidase, putative {ECO:0000313|EMBL:EEC05395.1, ECO:0000313|EnsemblMetazoa:ISCW005124-PA};
DE EC=3.4.11.9 {ECO:0000313|EMBL:EEC05395.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW005124 {ECO:0000313|EMBL:EEC05395.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC05395.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC05395.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW005124-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW005124-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR EMBL; ABJB010285922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010304044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010735816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS703412; EEC05395.1; -; Genomic_DNA.
DR RefSeq; XP_002433995.1; XM_002433950.1.
DR AlphaFoldDB; B7PFM3; -.
DR STRING; 6945.B7PFM3; -.
DR MEROPS; M24.009; -.
DR PaxDb; 6945-B7PFM3; -.
DR EnsemblMetazoa; ISCW005124-RA; ISCW005124-PA; ISCW005124.
DR KEGG; isc:IscW_ISCW005124; -.
DR VEuPathDB; VectorBase:ISCI005124; -.
DR VEuPathDB; VectorBase:ISCP_006428; -.
DR VEuPathDB; VectorBase:ISCW005124; -.
DR HOGENOM; CLU_011781_2_2_1; -.
DR InParanoid; B7PFM3; -.
DR OMA; EPGMILS; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 1: Evidence at protein level;
KW Aminopeptidase {ECO:0000313|EMBL:EEC05395.1};
KW Hydrolase {ECO:0000313|EMBL:EEC05395.1};
KW Protease {ECO:0000313|EMBL:EEC05395.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PFM3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 52..190
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 365..577
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 589..653
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC05395.1"
SQ SEQUENCE 654 AA; 74159 MW; E57725D09E6F1A2D CRC64;
WCSHLGRLVE EEHVGFCVRE PRSRLARLFA AADEPSTSEP LDMALRNTGT LLKRLRALMK
NTTHVSETIQ AYIVPSGDAH QSEYIAPCDK RRAFLTGFTG SAGTAIVTED QAALWTDGRY
FLQAEQQLDS NWILMKDGWS RSKQTTWLWV QVLSSGSRVG VDPFLMPYDA WKQLCNQLDA
SGHSLVPVSQ NLVDLIWEER PSPPSRPLDS LSIIYTGKFW QDKIADIRQD MTQKSASVLV
ITALDEIAWL FNLRGSDIDY NPVFFAYAVI TMDSAHLFID ENKLSATLQR HLSADRNEKS
VAVDIRPYRV FKDFLSLLIN QQSGKIWVSS CSSYAVVSQV PKERRIESTN PVMLRKAIKN
ETEIECMRRA HIKDAVALCE FFVWMESQVP KGEVTEITAA AKLEHFRRCQ EDYVGPSFET
ISASGPNAAI IHYRPEEDSD RRVTTEEVYL CDSGGQYRDG TTDVTRTWHF GMPSQYEKEC
FTRVVKGNIA LSSAIFPRLV KGQMLDTLAR RALWEVGLDY LHGTGHGVGA YLNVHEGDWM
PHPNDPGLQE GMILSIEPGY YEDNQFGIRI ENLVLVRKAA TKYNFKDRGF LAFDSLTLVP
IQTKMLNPLM LTADEVEWLD TYHQACRDVI GRALEEQGRD LALQWLLRET QPLG
//
