ID B7PIF4_IXOSC Unreviewed; 1142 AA.
AC B7PIF4;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Phosphatidylinositol 3-kinase class, putative {ECO:0000313|EMBL:EEC06376.1, ECO:0000313|EnsemblMetazoa:ISCW004026-PA};
DE EC=2.7.1.154 {ECO:0000313|EMBL:EEC06376.1};
GN ORFNames=IscW_ISCW004026 {ECO:0000313|EMBL:EEC06376.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC06376.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC06376.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW004026-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW004026-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00879}.
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DR EMBL; ABJB010091313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS718559; EEC06376.1; -; Genomic_DNA.
DR RefSeq; XP_002404927.1; XM_002404883.1.
DR AlphaFoldDB; B7PIF4; -.
DR STRING; 6945.B7PIF4; -.
DR PaxDb; 6945-B7PIF4; -.
DR EnsemblMetazoa; ISCW004026-RA; ISCW004026-PA; ISCW004026.
DR KEGG; isc:IscW_ISCW004026; -.
DR VEuPathDB; VectorBase:ISCI004026; -.
DR VEuPathDB; VectorBase:ISCP_022067; -.
DR VEuPathDB; VectorBase:ISCW004026; -.
DR HOGENOM; CLU_002191_0_1_1; -.
DR InParanoid; B7PIF4; -.
DR OMA; CWNSANI; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IBA:GO_Central.
DR GO; GO:0035005; F:1-phosphatidylinositol-4-phosphate 3-kinase activity; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IBA:GO_Central.
DR GO; GO:0036092; P:phosphatidylinositol-3-phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04012; C2A_PI3K_class_II; 1.
DR CDD; cd00864; PI3Ka; 1.
DR CDD; cd05166; PI3Kc_II; 1.
DR Gene3D; 3.10.20.770; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR000341; PI3K_Ras-bd_dom.
DR InterPro; IPR015433; PI_Kinase.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10048:SF14; LD28067P; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00792; PI3K_C2; 1.
DR Pfam; PF00794; PI3K_rbd; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51546; PI3K_RBD; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EEC06376.1};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EEC06376.1}.
FT DOMAIN 42..140
FT /note="PI3K-RBD"
FT /evidence="ECO:0000259|PROSITE:PS51546"
FT DOMAIN 300..454
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 460..636
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 704..978
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 1015..1130
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 1142 AA; 130144 MW; DA9C62FC17323D89 CRC64;
MSHFFKFVQA RLVKKQPNHH SQRLLRKLQH LVCDVQPEDS PYSGLLISPT LQNNSEETFD
VKLKIFSEQL HKPVCFSCPA ATRVGYLVES IQPFLGSPGK YVFKVTGLDE YLSNDTLLSD
YAYICACRRV GKVAWLTIVN LDNVQKPWTL VTSESCDLDI DVSEKITFVA VRDALETFES
QVEELIGVAL SVGGDLVKAA GDIRASVTEL CQLLNHTETS ELYQTTTDLL NFFRDTLSEN
RDGVDAPRKV FLVTRFVEDI ELAIARFLAM HSQRRSVEFT VEFLDESLRR RRTVDANELF
SPKVEMLVQL QKAWVQNYDS YSVDCALTYG ERLFSYQTTR RLYVTQRIFQ CVNFDEYISF
KNIQIRSLPR ETRMYLTVVG HRDGADHVLG WTGLNIFADR EHFNGGEFLL GLWSPEMLST
RGPVSASEQN KGCLLVTLPH VKNQAVLAKS ITRNVREVVR KPFHELSADV QQTFLDLTVT
DVSTPLPTYV RDLIWEHRHH LCDFSSLLPH LLKLPVCWNS ANIEETYTLV RSWCPLSPEE
SLTLLSPAFP DSLVKKYAVQ SLQSVGSDEL SLYLAQLVES LRFQNWDDSF LATFLLRRAR
QSVRLAHQLF WWLTGMINEP LMRDRALIMR KALFFVAGEK VTASLLTQIV ADEMLAETAR
SVKQAADSQK EEVMRRELAK LNSSLQVLKL RLPLDPAISV ESVDVDTCCV FPSKTLPVKL
VFRSSEEAAE KIETIYKAGD DLRQDVLILT VIRLMDKLWL ESGMDLKMLT FKCTTTGESR
GFLEAVRDVS TLRTIQTNHS GVTGAFSNRT IADWLWKHNS CRPQYQAAVD NFIKSCAGCC
VATYVLGVGD RHNDNILLAT SGHMLHIDFS KVLGHAETFG GIRRDRAPFA LTQDMVYVIR
RNGGEAQFVR LCCEAYNVLR RNSSLFLALF SIMKHSGLPD VDQDALAYLR RSMSLEATDE
QAARHFEKRI RESVMTLATS FNFFIHNLAS LGANTRECAL RLSFNPRDFS IAAEGKIVQL
TVEDIRLRYH PERYYVYVVN VEREFPPAQS VIRTYKNFLE LYTKMSRKFP ACDFHPLSRG
SVFSSEGDES LALKRKRDIQ QFLDTVMAQP EDVSHYRLVY SFFHPLPRDL ELLNGVPITI
AT
//
