ID B7PL68_IXOSC Unreviewed; 465 AA.
AC B7PL68;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 08-NOV-2023, entry version 77.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=IscW_ISCW006354 {ECO:0000313|EMBL:EEC07340.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC07340.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC07340.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW006354-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW006354-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010862904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010921664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011061823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS738229; EEC07340.1; -; Genomic_DNA.
DR RefSeq; XP_002434516.1; XM_002434471.1.
DR AlphaFoldDB; B7PL68; -.
DR STRING; 6945.B7PL68; -.
DR PaxDb; 6945-B7PL68; -.
DR EnsemblMetazoa; ISCW006354-RA; ISCW006354-PA; ISCW006354.
DR KEGG; isc:IscW_ISCW006354; -.
DR VEuPathDB; VectorBase:ISCP_004825; -.
DR VEuPathDB; VectorBase:ISCW006354; -.
DR HOGENOM; CLU_588345_0_0_1; -.
DR InParanoid; B7PL68; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20355; Rcat_RBR_RNF19; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR11685:SF427; RBR-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF01485; IBR; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51873; TRIAD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT TRANSMEM 157..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..147
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 465 AA; 48170 MW; 4846E11FC2183DE2 CRC64;
MSTGPSTSMG HLEGPLGPPR RHNPGSRFSL RRLFGSSSAF LNRRAFGRGS AKGLPASTLD
AEQALRIPSG ATASDGARAA SQRLTAPPKV GDDIKHCPCC KVFIIKMDDG SCNHMTCRLC
GTEFCWLCMK EISDLHYLSP SGCTFWGKKP WSRKKKILWQ LGMLVGAPVG IALIAGIAVP
AIVIGIPVWV GRKLHSKYDL RTTSRLKRNF IVSGGVVASF LVSPIIAGIA VGIGVPILLA
YVYGVVPVSL CRSGGCGVTT SASGVRIEFD EDADLGMSSG TAADGASVDT TGGVGILGAG
GATASIGEAA SLGMSGSPSL GSHLDTATAS NTAIAGHSLT GSITSASASH RLEVQAEVSS
NKRFSLSSHS ETASATVSLS ERSANMSGMA DDAASTRALA GSIVGYREGT LAAPVEVHVD
PLEEPDYCRH CRITHRPCCP NALPSSQPHH CECLDGVSVT KVQIE
//
