ID B7PN23_IXOSC Unreviewed; 1939 AA.
AC B7PN23;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Neurobeachin, putative {ECO:0000313|EMBL:EEC07995.1, ECO:0000313|EnsemblMetazoa:ISCW018522-PA};
DE EC=3.4.24.13 {ECO:0000313|EMBL:EEC07995.1};
GN ORFNames=IscW_ISCW018522 {ECO:0000313|EMBL:EEC07995.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC07995.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC07995.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW018522-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW018522-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010178766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010459427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010461048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010480551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010595081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010687700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010856134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010860524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010898542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010962435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS749722; EEC07995.1; -; Genomic_DNA.
DR RefSeq; XP_002435171.1; XM_002435126.1.
DR STRING; 6945.B7PN23; -.
DR PaxDb; 6945-B7PN23; -.
DR EnsemblMetazoa; ISCW018522-RA; ISCW018522-PA; ISCW018522.
DR KEGG; isc:IscW_ISCW018522; -.
DR VEuPathDB; VectorBase:ISCI018522; -.
DR VEuPathDB; VectorBase:ISCP_002029; -.
DR VEuPathDB; VectorBase:ISCW018522; -.
DR HOGENOM; CLU_000218_2_0_1; -.
DR InParanoid; B7PN23; -.
DR OMA; PMMMSGS; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF160; NEUROBEACHIN; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000313|EMBL:EEC07995.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PN23};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 187..673
FT /note="DUF4704"
FT /evidence="ECO:0000259|Pfam:PF15787"
FT DOMAIN 1763..1926
FT /note="DUF1088"
FT /evidence="ECO:0000259|Pfam:PF06469"
FT REGION 711..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..1125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1226..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1416..1438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1487..1541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..914
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..956
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..1000
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1052
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1228..1244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1524..1538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1939 AA; 212324 MW; DCCD028D35FB8452 CRC64;
MCFRTSKGVG YSAHFVGNCL IFTSMKVKGK GYQHCVKYEF QPRKWYTVAI VYIYNRWSKS
EIKCFVNGQL ASSTEMSWFV STNEPFDKCY IGAAPELDDE HVFCGQMSAV YLFSEALTAH
QVCAIHRLGP GYQSQFRFEG ESMTLPESLK RVLYDGKLSS AMVFMYNPMA TDSQLCLQAA
PKGNVSYYVH TPHSLMLQDV KAVTTYSIHS TLNSIGGIQV LFPLLAQLDY PMGLLPLPGS
QDKKPTICAT LIGFICEMCE SSSTVQQHMI QNKGFLVVSY QLQRASREHI TDEVLHSFLS
LTKHLLTVYS SNGELLLKHL LDHILFNPAL WIYTPTIVQT KLYTYLATEF LGDTQIYNNV
RRVSTVLQTM HTLKYYYWVV NPRNKSGITP KGLDGPRPNQ NDILSIRAYM LIFLKQLILK
GNGVKEDELQ SILNYLTTVH EDENLHDVLQ MLMNLMAEHP ASMVPAFDCK NGVRAIFKLL
GSTNESIRLQ ALKLLGYFLS RSTHKRKHDV MTPHNLYMLL AERLLLHSDH LTMATYNALY
EMLTEHISNQ ILYTKHSEPE SHYRLENPMI LKVVATLIRQ SKPCEELIEV KKLFLSDMTL
LCNNNKENRR TVLQMSVWQE WLVAMAYIHP CNAEEQKISD MVYALFRMLL HHAIKYEYGG
WRVWVDTLAI VHSKVSLEEY KLHFAQMYEH FDQRRVDHIT DPAVRRQRPI STISGLDRCP
PPEQECASQP SREAPPRPDI VQVREGERGE EEEEEERGNV TFPSIVPSTP SQVPDPVPSE
DVVPVVVESS DVTGAALPGP AVVCPDVIPV QESTKSLSEE KRPSLPPADG SSPVSDLSGG
EQGASPDVVP HPTDPTKAHA AEEAAREDAD EKLPGEPAES PVEDADVGRM EGVIGEEGDA
RRECIPDAAE MSDSNKDDQS ASTDSVSAER EELAVGEGSA ECEVFEDARG DDGSEASEEA
ALPEDAADDA AIVSDHGGHA DKADPTEPPL QERPEQRAEE GSTEVNSVAQ DEPEESESQT
KSVSPAEGPS DSPASLESAD ETSSTREVAS PAQSPEKLSG EPMGSHLPSI VNPTEELDVP
LPPPADDPLP QEGVVVATAV AEKEEPSSLD AVEDGNEDDG DDRLEAKRTI EQTNLLNAEA
SGDAAVISES DAEEEAAVEI GGISTIEAQV EIERRHMADL GFSTTAPMAE SASEEGAQEA
GVVRRARSAS QTTVEKAVLA PTRPKSVEMA PGTTSGSASA GRQLFNAGPS RPPFRIPEFR
WSPIHQRLLS DLLFSLETDI QVWRSHNTKT VIDFVNSGEN AIFVINTVHL ISQLADNIII
ACGGLLPLLA SATSPNHELD VIEPTQGMAI EVAVAFLQRL VYMTDVLVFA SSLSFSDLEA
EKNMSSGGIL RQCLRLVCTA AVRNCLECRE RSCPLTPVTP LTPQTPTSRD PLRPNPIHAL
IGGVQPSAKN IVENLGGQSS PIRDPEKLLQ DMDVNRLRAV IYRDQQQRAE GGHTHHHHAP
PNSASAAGPV PRSAAAAPPH QLGPSSDGTA QQARVEAQMA DKSGNAAVLW SESQEGEKDE
VIVVEEMGSS ILANIHSSAA VISTSSVPNT VNSVPVAAAY HHPENVNGSG EPEPLTATNP
HNYPATILVP QEPALNGVNK VPEGGVGGNL KAGGPEALRL APLGPSGVTE GPNTREASLT
QKLEGALGSV CPLLREIMVD FAPFLSRTLV GSHGQDLLVE GKGLSTFKNS TSVVELVMLL
CSQEWQNSLQ KHAGLAFIEL INEGRLLSHA MKDHIVRVAN EAEFILNRMR ADDVLKHAEF
ESLCAQTAVD RKEEEMMCDH LITAARRRDS LVAGRALEKV LNILTNRHGA WGYAARPHKG
GTCSPGENEF LRLDAWEDDA RRRKRLVRNP HGSCHPEGTL KAAIEHGAPE DAILQAREEL
HRQLAVQSVA LAHKGLWLL
//
