ID B7PSP3_IXOSC Unreviewed; 674 AA.
AC B7PSP3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=non-specific protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011903};
DE EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW019316 {ECO:0000313|EMBL:EEC09615.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC09615.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC09615.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW019316-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW019316-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001149};
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DR EMBL; ABJB010737936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS779705; EEC09615.1; -; Genomic_DNA.
DR RefSeq; XP_002402800.1; XM_002402756.1.
DR AlphaFoldDB; B7PSP3; -.
DR STRING; 6945.B7PSP3; -.
DR PaxDb; 6945-B7PSP3; -.
DR EnsemblMetazoa; ISCW019316-RA; ISCW019316-PA; ISCW019316.
DR KEGG; isc:IscW_ISCW019316; -.
DR VEuPathDB; VectorBase:ISCI019316; -.
DR VEuPathDB; VectorBase:ISCP_003719; -.
DR VEuPathDB; VectorBase:ISCW019316; -.
DR HOGENOM; CLU_005265_0_0_1; -.
DR InParanoid; B7PSP3; -.
DR OMA; NQFQQLT; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0065008; P:regulation of biological quality; IEA:UniProt.
DR CDD; cd05041; PTKc_Fes_like; 1.
DR CDD; cd10361; SH2_Fps_family; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR035849; Fes/Fps/Fer_SH2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR016250; Tyr-prot_kinase_Fes/Fps.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24418:SF418; TYROSINE-PROTEIN KINASE FER; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00017; SH2; 1.
DR PIRSF; PIRSF000632; TyrPK_fps; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50001; SH2; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000632-2, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EEC09615.1};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000632-2, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PSP3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EEC09615.1};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT DOMAIN 1..192
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 313..404
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 416..668
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT COILED 67..117
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 246..273
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 538
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000632-1"
FT BINDING 422..430
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000632-2"
FT BINDING 445
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000632-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC09615.1"
SQ SEQUENCE 674 AA; 77789 MW; 66C990664BEE781D CRC64;
AWNTIIDTTE TVGRLVKQNA DLIATHTLDK LSCLILEKRA LRKIYLEEHQ RIHGELARLR
DAVLKSTSEY EKCIENATAA KEKYEDQFMK GRGNRKVEEA KERYLKASRK LHQTHNDYIL
LLNEAMNYEH HLRTTLLPGL LQYQQTVQQE AIDCWQAVMR DYSRHTDFCS EAFQSVHKKL
NESIDFIKSE SEYQDFIEKY KSKPIPPIDF HYDESLLNNY VGKLKPEQIA VDEFTIDALR
ERAMVKKRAV DIIRRERDEI KCQEERINSQ LQLLVQPLSS IGSEVPRGLD LDITVNGEQM
SVNPNVVLQD EDWFHGVLPR EEVVRLLVNN GDYLVRETMR NEEKQVVLSV CWQGHKHFIV
QTTSDGKYRF EGPAFGTVQE LIVYQHHLGL PVTSKSGAIL QNPIFRERWE LNNDDVELVE
KIGRGNFGDV YRAVLHPQRT EVAVKTCRVN LPDEHKKKFL QEGRILKQYD HPNIVKFIGI
CVQKQPIMIV MELVPGGSLL AFLRNQGPKL NPKELLNMCI DTAAGMAYLE SKNCIHRDLA
ARNCLVGRNN TVKISDFGMS REEEEYIVSD GMKQIPIKWT APEALNFGKY TSVCDVWSYG
ILAWEIFSLG ASPYCGMSNS RARELIDTGY RLPSPEHTPG PVYELMLRCW EYNPDKRPSF
YDIHHTLVSI SKHG
//
