ID B7PVZ1_IXOSC Unreviewed; 372 AA.
AC B7PVZ1;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=3 hydroxysteroid dehydrogenase, putative {ECO:0000313|EMBL:EEC10763.1, ECO:0000313|EnsemblMetazoa:ISCW007167-PA};
DE EC=5.3.3.1 {ECO:0000313|EMBL:EEC10763.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW007167 {ECO:0000313|EMBL:EEC10763.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC10763.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC10763.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW007167-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW007167-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR EMBL; ABJB010122259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010187302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010421770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010583089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010716336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010889911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010960114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011109487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011119465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS803490; EEC10763.1; -; Genomic_DNA.
DR RefSeq; XP_002408861.1; XM_002408817.1.
DR AlphaFoldDB; B7PVZ1; -.
DR STRING; 6945.B7PVZ1; -.
DR PaxDb; 6945-B7PVZ1; -.
DR EnsemblMetazoa; ISCW007167-RA; ISCW007167-PA; ISCW007167.
DR KEGG; isc:IscW_ISCW007167; -.
DR VEuPathDB; VectorBase:ISCI007167; -.
DR VEuPathDB; VectorBase:ISCP_028471; -.
DR VEuPathDB; VectorBase:ISCW007167; -.
DR HOGENOM; CLU_007383_6_3_1; -.
DR InParanoid; B7PVZ1; -.
DR OMA; ACIIDVS; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0004769; F:steroid delta-isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:EEC10763.1};
KW Membrane {ECO:0000256|RuleBase:RU004475};
KW Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|RuleBase:RU004475};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004475"
FT DOMAIN 14..174
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
FT DOMAIN 224..291
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC10763.1"
SQ SEQUENCE 372 AA; 41324 MW; 0E9A118E271F30D9 CRC64;
FNALSGGRPV AVVLVTGSSG FLGQHVVRLL QEDQSKVREI RLFDARPYKN NLGHRTDKPM
REIVGTICDV EAVAQAFSGV DCVIHCASLI DVNFFKNVEA MERVNVQGTR NVIEACIAQN
VPHLVYTGTV GVDDGTGGWG DSVVEHCHQG PYADTKHRAE QLVLAANARL LADALYILKT
SENSVEDWRE KTFLVITRLL ACENGAKRRY DKDMNLCCYP NRREALRSSC APCSMQMSYV
GNAAAAHIHA MRRLARDGDI SGQVFTVTDD TPTDGLQFML PFVESRGLAV SRFALPYSVA
LVFSLLLTSV LTLLRPLYTI KVPFPTPSDI RYIFKAPFFD GTRAKTVLGF EPWFSVEESV
RMSMSYYRAI QL
//
