ID B7PX40_IXOSC Unreviewed; 948 AA.
AC B7PX40;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 08-NOV-2023, entry version 83.
DE RecName: Full=Dynamin-like 120 kDa protein, mitochondrial {ECO:0000256|ARBA:ARBA00018307};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW019381 {ECO:0000313|EMBL:EEC11162.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC11162.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC11162.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW019381-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW019381-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001837};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004325}.
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DR EMBL; ABJB010946604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS811420; EEC11162.1; -; Genomic_DNA.
DR RefSeq; XP_002410494.1; XM_002410449.1.
DR AlphaFoldDB; B7PX40; -.
DR STRING; 6945.B7PX40; -.
DR PaxDb; 6945-B7PX40; -.
DR EnsemblMetazoa; ISCW019381-RA; ISCW019381-PA; ISCW019381.
DR KEGG; isc:IscW_ISCW019381; -.
DR VEuPathDB; VectorBase:ISCI005274; -.
DR VEuPathDB; VectorBase:ISCP_005720; -.
DR VEuPathDB; VectorBase:ISCW019381; -.
DR HOGENOM; CLU_012302_0_0_1; -.
DR InParanoid; B7PX40; -.
DR OMA; ESQTDAF; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0008053; P:mitochondrial fusion; IBA:GO_Central.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR045817; OPA1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF67; DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF19434; OPA1_C; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 1: Evidence at protein level;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PX40};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 271..547
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 187..239
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC11162.1"
SQ SEQUENCE 948 AA; 109149 MW; 8AE8A59AD7CFCE47 CRC64;
KSSMLQYKAL PVARYGVGFS PHRWSSPRLV RARKHHTLNA NYRHRLRIYR SIPTLQSSRN
IVLVARVLRG VLKIRYIILG SAVGGGVQLS KKYEEWKDNL PDFPDFGWVK DKMPSPESID
KFRASLIEMK DKLALSEKFR SGADAAATGF ASVSEWLRTV KFESSPSVNG TGFDDFATAM
AVAPLFSSQE DARRENERER MQKLQDELIH VQMKYQKEIE RLEKENKELR RQIMLKTEKA
VSRRKIKKSL IDLYSEVLDE LCDYDSSYNV QDHLPRVVVV GDQSAGKTSV LEMVAQARIF
PRGAGEMMTR APVKVTLSEG PYHIAKFKDS SREFDLTKET ELSDLRREVE LRMKNSVRGG
KTVSNDVISM TVKGPGLQRM VLVDLPGIIS TATTEMAEGT KDAIREMTSA YMNNPNAIIL
CIQDGSVDAE RSIVTDLVSQ VDPNGRRTIF VLTKVDLAEQ NMANPTRIRK ILDGKLFPMK
ALGYFAVVTG RGSNDDSITA IKAYEEMFFR NSRLCRDGIL NMSQCTTQSL SLAVSDCFWK
MVRESVEQQA DAFKAQRFNL ETEWKNSFPR MRELDRDELF ERSRGELLDE VVNLSQLSPK
HWEEVLSKNL WGDMSSYVID SIFLPAAQTG NAGNFNTAVD IRLKLWAEKL LPSQSVDVGW
RTLRDEFHGL LQKRKASKDH DPLFDQLMLA VVQEVIDRHE WEDKAVDMLR LIQLNALEDR
VVHDKHQWDQ AVRFLESALH DRLHAAEARI QDMVGPGVRD QWLYWMSPTE EQKHRAVVRS
ELERLLSTEF LQKHGPSLTQ EELTTVRKNL QARDVDVDYK FIRDTWEPLY RLHFLRRSLA
KANDCRKGYY LYHQGLDSEL ECHDVVLFWR VQRIMHTTAN VLRQQVMNRE ARRLEKGVKE
VLDDFSQDSE KKVQLLTGRR VELAEELKKV RQIQEKLEEF VGALNAEK
//
