ID B7Q0T5_IXOSC Unreviewed; 1477 AA.
AC B7Q0T5;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Mitogen activated protein kinase kinase kinase 1, MAPKKK1, MEKK1, putative {ECO:0000313|EMBL:EEC12457.1, ECO:0000313|EnsemblMetazoa:ISCW010233-PA};
DE EC=2.7.11.25 {ECO:0000313|EMBL:EEC12457.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW010233 {ECO:0000313|EMBL:EEC12457.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC12457.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC12457.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW010233-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW010233-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010026368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010091792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010540587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010589624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010591411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010694671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010770800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010808852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010828455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011038474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS833764; EEC12457.1; -; Genomic_DNA.
DR RefSeq; XP_002408296.1; XM_002408252.1.
DR STRING; 6945.B7Q0T5; -.
DR PaxDb; 6945-B7Q0T5; -.
DR EnsemblMetazoa; ISCW010233-RA; ISCW010233-PA; ISCW010233.
DR KEGG; isc:IscW_ISCW010233; -.
DR VEuPathDB; VectorBase:ISCI010233; -.
DR VEuPathDB; VectorBase:ISCP_013877; -.
DR VEuPathDB; VectorBase:ISCW010233; -.
DR HOGENOM; CLU_005805_0_0_1; -.
DR InParanoid; B7Q0T5; -.
DR OMA; HHTRMRR; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004709; F:MAP kinase kinase kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR007527; Znf_SWIM.
DR PANTHER; PTHR48016; MAP KINASE KINASE KINASE SSK2-RELATED-RELATED; 1.
DR PANTHER; PTHR48016:SF29; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1A; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF04434; SWIM; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50966; ZF_SWIM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:EEC12457.1};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00325};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transferase {ECO:0000313|EMBL:EEC12457.1};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00325};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00325}.
FT DOMAIN 456..484
FT /note="SWIM-type"
FT /evidence="ECO:0000259|PROSITE:PS50966"
FT DOMAIN 1201..1466
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 921..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1124..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..370
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1230
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC12457.1"
SQ SEQUENCE 1477 AA; 160425 MW; A429D071A7A9EFF5 CRC64;
PSISADGFPG GVELAERSRR RRESVGRRLR RRPPTAAVLT GVPDLPPADL QSRPAERVWH
AEFAQRRGVA VRMIRAADGM PSHARAPTRN GMRRLGASRE VPRRCRAPRW PEGIRGRPFG
TPESPLRPPS AESFTAPHAA CLLKTAKPPS KLPGGMEEIA ESIKCSLEEL PPTPGMSSDP
GPRGGVQGGL GCRSVLGPLA RVGREKGVKR RGLSEFRPDA ILSARSSDHL SHNGLAQNQR
IPPAYLLSWF SDPAWSRSRE KRMAAQLDRL QQVYPVSVRQ IKERLHALRK PAQATQGRRT
PLAVRHEAAA EADDAEAHGI PDAKKQERGE LALGDAPGAT AVLPAVKRPS RKPSPPPPPV
RPPETPEAPP AAGSPDQRTT KTRTSHHRST TPPSRSRGSS PARRRSPSPA PEYPPGVMES
IRRRVLQVRR GARLYLLCQP GPRSFLVAAD QPDHRFKVVV GPQTCTCGKG PLCVHLLFVM
LRVLKVRDSD PRLFSKTLKN YEVDELLRAY SAWRRRSSLQ SEGGSSDLRS PDGPQPDLPG
DPSPGGAEEA SQDTEEDEKS TCPICLLEMF EGESLVSCER GCRNRLHHHC IAIYAPPLPR
PVGTGSAPAS ASLLARFFGV EVALCMASAS WSEREAAIQE VEAQVTHALR LALSNPSCLD
PWGGAEVVQA ACCQVVAAGI ADPVYRVYVT ALRCLKSMLV HSPCHILEDL RNLQSRVRNI
VRAILVKCAS GGNKRSRQLS LATLAELAKG QTGALSVGSL TNYPAPDGLG ADFLLEVVLF
EGKLTPTWQG LLSQLLVLQR LAEEFPRVLA SPIIATGTSN ADSIVAVDLA VKALGHSHAT
VVRHGRELLA SLARICGRCP TTVAHIWDGV ASLQGHLRAQ LVRRVGAALQ ETRNLRLVFG
QPPPDRLQEA NLVRERLLHT RDSRGGSKVS SPGCQSPHSA SPSRMPTFQL PPPSIDPELF
HHLLPGGKPC TDRDQGYCVK SKTSVPAPSV RFHSPRHLAF PSQRSGESTP QRDLAPPPRR
PCSSPSIERR LRESLFSSGR SSWSSNSSET KNDGADSRRS ALSPPPPPRV LRGHRPNFLP
LRRLACSLSL GHATSSSQTS PGSVGDVGSP VSFAAEIEAL SCALPPEEDG DVPPNRGVTT
NPGSPTNTAG FTHCGDTTPG YCDAADMQDE EFIVFRPLTE LPMWPSRGEG GRRRYAEGEH
WRRGPLLGSG AFSSCYQAVD ITLGTLLAVK QMSFCRNCRE EEDSAVASMW DEIQMMARLG
HPNVLPLLGA TRHMNHYNVF VQWMAGGSVA SMLDRYGPFS ESVILRYTHQ VLGGLAYLHQ
NHILHRDLKG ANLLVDGTGR HLKIADFGSA SRLSSKATLA GEFRGQLLGT ISFMAPEVLR
GEDYGRSCDI WSVGCVMIEM ATNAHPWSEI MAPNHLALIY RISCARSPPP VPESLTLPTQ
HLVLRCLQLR SQDRPPAGDL LSHPCFRKIG LCPMKDP
//