ID B7Q4F0_IXOSC Unreviewed; 422 AA.
AC B7Q4F0;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Ankyrin repeat containing protein {ECO:0000313|EMBL:EEC13722.1, ECO:0000313|EnsemblMetazoa:ISCW021441-PA};
GN ORFNames=IscW_ISCW021441 {ECO:0000313|EMBL:EEC13722.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC13722.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC13722.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW021441-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW021441-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Target cell
CC membrane {ECO:0000256|ARBA:ARBA00004175}.
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DR EMBL; ABJB010359285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS855301; EEC13722.1; -; Genomic_DNA.
DR RefSeq; XP_002411530.1; XM_002411485.1.
DR AlphaFoldDB; B7Q4F0; -.
DR STRING; 6945.B7Q4F0; -.
DR PaxDb; 6945-B7Q4F0; -.
DR EnsemblMetazoa; ISCW021441-RA; ISCW021441-PA; ISCW021441.
DR KEGG; isc:IscW_ISCW021441; -.
DR VEuPathDB; VectorBase:ISCI021441; -.
DR VEuPathDB; VectorBase:ISCP_025175; -.
DR VEuPathDB; VectorBase:ISCW021441; -.
DR HOGENOM; CLU_048951_0_0_1; -.
DR InParanoid; B7Q4F0; -.
DR OMA; NNYVTRS; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0044231; C:host cell presynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0044218; C:other organism cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR24150; ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR24150:SF8; ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF01753; zf-MYND; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 1: Evidence at protein level;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Membrane {ECO:0000256|ARBA:ARBA00022537};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Neurotoxin {ECO:0000256|ARBA:ARBA00022699};
KW Presynaptic neurotoxin {ECO:0000256|ARBA:ARBA00023028};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7Q4F0};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Target cell membrane {ECO:0000256|ARBA:ARBA00022537};
KW Target membrane {ECO:0000256|ARBA:ARBA00023298};
KW Toxin {ECO:0000256|ARBA:ARBA00022656};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT REPEAT 43..75
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 77..109
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 324..361
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT REGION 374..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 422 AA; 46990 MW; DEF52479F68AE3D3 CRC64;
MAPLTKGELS DTEKELYKAV QAGDLTEART LLNKVRIDCL DEHGMTPLQH AAYRGNYDMC
KLFLECGADV NSHFHDSGYT ALMFAGLAGR ADVVSLLLEH GASTTAVNSL GRTAAQMAAF
VSNYDVVAIV NNFLPREELD YYARPQGLEK EPKLPANLVS PLYHLILRTN IHPVRVALYL
QDRRDLLDNS AKIERVLTLL CEKQMKAVAE PNEMLALKFH HLAFLVRNCA KFARDQDPKK
AGSKALLEPL IKTWLKGRDE DDFPVLLEKL LRQSVREFPY HDCSVLQQLV HTLSGVEIGN
EPSAISILAE AIRGQKGCDQ AASCTACGEP KAEKRCSACK SVQYCDPGCQ KLHWFTHKKH
CARLATEYEQ ALREKAEQEK EQELERAKTE AVKQDNGTEE QPAEEDASSS TAEPKTLPSA
LQ
//
