ID B7Q4U1_IXOSC Unreviewed; 491 AA.
AC B7Q4U1;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Cytochrome P450, putative {ECO:0000313|EMBL:EEC13863.1, ECO:0000313|EnsemblMetazoa:ISCW021011-PA};
DE EC=1.14.99.22 {ECO:0000313|EMBL:EEC13863.1};
GN Name=8035926 {ECO:0000313|EnsemblMetazoa:ISCW021011-PA};
GN ORFNames=IscW_ISCW021011 {ECO:0000313|EMBL:EEC13863.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC13863.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC13863.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW021011-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW021011-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; ABJB010297169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011050402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011115323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS857608; EEC13863.1; -; Genomic_DNA.
DR RefSeq; XP_002401077.1; XM_002401033.1.
DR AlphaFoldDB; B7Q4U1; -.
DR STRING; 6945.B7Q4U1; -.
DR PaxDb; 6945-B7Q4U1; -.
DR EnsemblMetazoa; ISCW021011-RA; ISCW021011-PA; ISCW021011.
DR GeneID; 8035926; -.
DR KEGG; isc:IscW_ISCW021011; -.
DR VEuPathDB; VectorBase:ISCI021011; -.
DR VEuPathDB; VectorBase:ISCP_019800; -.
DR VEuPathDB; VectorBase:ISCW021011; -.
DR HOGENOM; CLU_001570_28_0_1; -.
DR InParanoid; B7Q4U1; -.
DR OMA; KQFCPER; -.
DR OrthoDB; 3108669at2759; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0004501; F:ecdysone 20-monooxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR CDD; cd11054; CYP24A1-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24279; -; 1.
DR PANTHER; PTHR24279:SF117; -; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033,
KW ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461,
KW ECO:0000313|EMBL:EEC13863.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
SQ SEQUENCE 491 AA; 55468 MW; 6313AFDF6F39B0FD CRC64;
MKQGARVLAR SVGSETPSII ALGHAEATPA AKQAQRRVVT PLADARTYPK PFHQIPGPKP
SLPLIGTSWQ YFRWGRYSLY QLHEACADKY RRYGDVMKEE YQWQVPIVHA FNPEDFETIF
RHQGRCPIRP ANEFVRKYRT EHPHKYSNVG LSNALGEEWH TLRTALAPVL LQMRSVPGLA
AQQSEICEDF VSYVRFVRNS KSQAVDNIQD SLYRLALESI FMLCLDTRLG CLSRTVNYDS
DAAIVITAAK DLFSAYQKLY YGLPLWKFFS TSAYRSYQRA EETLYELTLS YLQKYANHDC
KDSAHAPYAK HTSLLHALLN TEGLSEKDVH LTIMDFIAGG VFTTTNALCF LLHHLACNPS
IQEKLHGELQ ASNGDVSGCS YLRACMKESF RLNPTVPGVM RILPEDVVLS GYHVPAGVPV
FANSLVTCHL EKYFAEPEAF RPERWLGAER TQIHPFSLLP FGHGARMCAG RRFAELELMT
AAAKVCLHTQ I
//
