ID B7Q750_IXOSC Unreviewed; 1182 AA.
AC B7Q750;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 08-NOV-2023, entry version 90.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN ORFNames=IscW_ISCW011536 {ECO:0000313|EMBL:EEC14672.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC14672.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC14672.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW011536-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW011536-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005231}.
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DR EMBL; ABJB010011032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010159126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010383679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010452428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010496252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010525468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010761132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010908026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010911618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011029637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS872141; EEC14672.1; -; Genomic_DNA.
DR RefSeq; XP_002412101.1; XM_002412056.1.
DR AlphaFoldDB; B7Q750; -.
DR STRING; 6945.B7Q750; -.
DR PaxDb; 6945-B7Q750; -.
DR EnsemblMetazoa; ISCW011536-RA; ISCW011536-PA; ISCW011536.
DR KEGG; isc:IscW_ISCW011536; -.
DR VEuPathDB; VectorBase:ISCI011536; -.
DR VEuPathDB; VectorBase:ISCP_038067; -.
DR VEuPathDB; VectorBase:ISCW011536; -.
DR HOGENOM; CLU_001042_9_0_1; -.
DR InParanoid; B7Q750; -.
DR OMA; HNKIAME; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0000793; C:condensed chromosome; IBA:GO_Central.
DR GO; GO:0000796; C:condensin complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0007076; P:mitotic chromosome condensation; IBA:GO_Central.
DR CDD; cd03273; ABC_SMC2_euk; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR027120; Smc2_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 2.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005719};
KW Oxidoreductase {ECO:0000313|EMBL:EEC14672.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7Q750};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 520..640
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 421..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 267..316
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 813..940
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 987..1014
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1182 AA; 132510 MW; A74B60EFFB5C4E98 CRC64;
MHIKSITIDG FKSYGQRVDI NGFDNLFNAI TGLNGSGKSN ILDSICFVLG ITNLSQVRAS
NLQDLVYKNG QAGVTKATVS ITFDNRDTRQ RPVGYEHFEE FTISRQVVVG GRNKYMINGV
TATTNRVQDL FRSVQLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYESKKQV
AQKTIEKKDA KIAELNNVLA EEITPTIEKL KEERQAYLAY TKVSRELDHL TKLYIAWQYV
ETENGSQQSG RRLEETKAKI SKSHTTIDEI NAKTKDIGKE IAELERRRKE ETGDRLDALE
KELKEKQLEE TKVNSDIQFT KDQIKGEAKN QAGFKKNMDE DNAALVSKQK QADKLQATVD
ALAESSQKDA EAVAAANKHF RAVTAGLSSN ADGEEATITE QLRAAKSDIA EAVTAMRQAE
MDLKHSQEES KKKQAECRKT ESSYQKDDAA NKAIEKDINL LKAQMSKLNY EEGKEEALLS
QKQQLQREVN TLSQKVDVFE ARWVPFPFHY TDPVKNFDRR KVLGLVCDLF TIKDKRAARA
LEMAAGGKLF NVVVDTEETG KLLLKSGRLK RRVTIIPLNK IVGRDVEPAV MKKAESLVGK
DKVFSALSLV DFTPVVASAM KYVFGTTLVT TNMDDARVVA FDSGVQKRTV SFDGASFDPS
GVVSGGTPSP HSCAGMGVLI NSCLRLCIFL VETAAMYRLA RCTSAPTLKP VTSLQVLWPE
ARAPWSRLRS SNRTGRHWPK PPPMQLPLPR SLLASRRLPT RKCCVLCFFL KFCVTLRLPV
SGVTRVECTT LLKIVTQSLL FKLTPFDGTF VGMLLLIQEA EGLQLEIEEL QKCLTGYNAQ
LEVSNNTLKD LEQALANHQQ KLNGTHMQEQ VSKANEDLKA QKEKLKAASR EIGAKYTERD
GLQKKADDLK LKIQQWEHDI SKVQKEAEDA RRKLEDLVKH YEWIPSEKQY FGQANTEYDF
TVNNPVEAGR RIQKLSETKE KLGQNVNSRA QNQLLKAEEK YQDLSKKKRT VLADKAKIMT
VIKELDEKKS LALKAAWKKV NKDFGSIFST LLPGTNAKLE PPDNMDVLDG LEVKVAFGGV
WKESLQELSG GQRSLVALSL ILSLLLFNPA PIYILDEVDA ALDLSHTQNI GQMLRTHFRQ
SQFIVVSLKE GMFNNANVLF RTKCVNGMSS VTRTAQRLEL DK
//
