ID B7Q9N8_IXOSC Unreviewed; 886 AA.
AC B7Q9N8;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Serrate RNA effector molecule homolog {ECO:0000256|ARBA:ARBA00017364};
DE AltName: Full=Arsenite-resistance protein 2 homolog {ECO:0000256|ARBA:ARBA00030701};
GN ORFNames=IscW_ISCW011341 {ECO:0000313|EMBL:EEC15560.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC15560.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC15560.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW011341-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW011341-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ARS2 family.
CC {ECO:0000256|ARBA:ARBA00005407}.
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DR EMBL; ABJB010239152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010464423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011062337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011140323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS890290; EEC15560.1; -; Genomic_DNA.
DR RefSeq; XP_002412526.1; XM_002412481.1.
DR AlphaFoldDB; B7Q9N8; -.
DR STRING; 6945.B7Q9N8; -.
DR PaxDb; 6945-B7Q9N8; -.
DR EnsemblMetazoa; ISCW011341-RA; ISCW011341-PA; ISCW011341.
DR KEGG; isc:IscW_ISCW011341; -.
DR VEuPathDB; VectorBase:ISCI011341; -.
DR VEuPathDB; VectorBase:ISCW011341; -.
DR HOGENOM; CLU_008560_0_0_1; -.
DR InParanoid; B7Q9N8; -.
DR OMA; FYRRGWA; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0031053; P:primary miRNA processing; IBA:GO_Central.
DR CDD; cd00590; RRM_SF; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR039727; SE/Ars2.
DR InterPro; IPR007042; SERRATE/Ars2_C.
DR InterPro; IPR021933; SERRATE/Ars2_N.
DR PANTHER; PTHR13165; ARSENITE-RESISTANCE PROTEIN 2; 1.
DR PANTHER; PTHR13165:SF0; SERRATE RNA EFFECTOR MOLECULE HOMOLOG; 1.
DR Pfam; PF04959; ARS2; 1.
DR Pfam; PF12066; SERRATE_Ars2_N; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 1: Evidence at protein level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7Q9N8};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 162..271
FT /note="SERRATE/Ars2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12066"
FT DOMAIN 651..819
FT /note="SERRATE/Ars2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04959"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 886 AA; 100034 MW; A3CA37F30397CC70 CRC64;
MGDSDEEYDR RRGRDKFRRE RSDYQERRDD RSRGRDDWPE RDSWSARDAR SRRDYRDYDV
RSRRGERYSP PRHDMSPPVK RMRRDWEDRG VYGGFEGGGF PVGGHHPGAG GPWGGGPPQD
MGGMVHMAAA QHAGGYAHNM AAGGPQREPE GGMTQPPMMT FKQFLGSQDD GIDDQEAVRK
YNEYKMDFRR QQLNEFFVNH KEEEWFKSKY HPEEFGKRKT EQMNALQRRL GVFLKLHETG
WIDAVSIDVE KSDRIVRLLD AVVILLEGGT EYDLQALDEP YQEEKPASDT LPSPDHSEGT
REDESQAKKE DEDSKSGRKS RSRSYSSSDQ SSSDSDSDDS RSEKEGKEEK AKKEEDRSED
GEGSSKAEDE EEARPDSTEA KEKAEGEEEE DKEAKADKKE GKGEEGEEKK GEDSKGRPRP
LHRTCSIFLR NLAPTITKLE VEAMCKRYPG FLRVAIADPQ AERRFFRRGW VTFERTVNIK
EICWNLNNIR LRDCELGAIV NRDLSRRIRS VNGIASHKQV VRSDIKLAAR IVHNLDEQRG
LWSPGLVTQP WSFGVSSKNP LLKNITDYLI EEASAEEEEL LGGPADREEG AEAEDSTATG
GTNLEKDDAL IKVLDRLLLY LRVVHSVDYY NQSEYASEDE MPNRCGIMHA RGSPPSSKVT
PQEVSDYINH FETKISSFLQ PTTKLTDDEA GRLGRKDPEA EVEKFVAANT QELAKDKWLC
PLSGKKFKGP EFVRKHIFNK HAEKVDEVRK EVEYFNNYLV DPKRPQLPEH PANRGGPPGG
GRGGPDGHVM GGGAPFHGGG FHPPPPFGFG RGHGPGFPGS ELRPKLPPTP PPRTLLGSSL
TDIVAVGEDA QAMLFPCFPF SRSPRGEPRK LITYRDLDAP NDMDFP
//
