ID B7QBB3_IXOSC Unreviewed; 345 AA.
AC B7QBB3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Purine permease, putative {ECO:0000313|EMBL:EEC16135.1, ECO:0000313|EnsemblMetazoa:ISCW013186-PA};
GN ORFNames=IscW_ISCW013186 {ECO:0000313|EMBL:EEC16135.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC16135.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC16135.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW013186-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW013186-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; ABJB010152840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010267312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010564964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010682586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010891477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010900342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010919309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010972208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010994908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS900056; EEC16135.1; -; Genomic_DNA.
DR RefSeq; XP_002412839.1; XM_002412794.1.
DR AlphaFoldDB; B7QBB3; -.
DR STRING; 6945.B7QBB3; -.
DR PaxDb; 6945-B7QBB3; -.
DR EnsemblMetazoa; ISCW013186-RA; ISCW013186-PA; ISCW013186.
DR KEGG; isc:IscW_ISCW013186; -.
DR VEuPathDB; VectorBase:ISCI013186; -.
DR VEuPathDB; VectorBase:ISCP_013705; -.
DR VEuPathDB; VectorBase:ISCW013186; -.
DR HOGENOM; CLU_804835_0_0_1; -.
DR InParanoid; B7QBB3; -.
DR OMA; YACASMS; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR11119:SF3; LD30822P; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7QBB3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 38736 MW; 37DA17F40EFFFCB7 CRC64;
MEPTRDQDRA TGEDNLQDSE RNDQLMDPAV DVLEPSEGVP LVSHNEATDR DTSMPPNHWD
FGKSAEAEER LGTLETQVPV ENGQETKLVR ESKSVESEKA MFYGVDDRPA WYFSAMLGLQ
HYLIVTSGAL SYPFALAPAL CMREEDPARG YLISTIFFIS GIGTLIQTTF GIRLPIIQGC
SVTFLVPILA TMALPEWRCP TEEQLVAARP SDSGLTGPAT DEEWTQVWQT RMSEVRRRLS
IILMTIFSQY FQNVALPVPA WNRGKGFHIR PFAIFKLFPI LLAILISWGA CFLMTETEYL
APGDAARTDI RASIIDKSPW IRVPYPGKDR SPSQMCDDVR ISIDR
//
