ID B7QK95_IXOSC Unreviewed; 443 AA.
AC B7QK95;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Sphingomyelin phosphodiesterase, putative {ECO:0000313|EMBL:EEC19267.1, ECO:0000313|EnsemblMetazoa:ISCW014980-PA};
DE EC=3.1.4.12 {ECO:0000313|EMBL:EEC19267.1};
GN Name=8042518 {ECO:0000313|EnsemblMetazoa:ISCW014980-PA};
GN ORFNames=IscW_ISCW014980 {ECO:0000313|EMBL:EEC19267.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC19267.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC19267.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW014980-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW014980-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the acid sphingomyelinase family.
CC {ECO:0000256|ARBA:ARBA00008234}.
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DR EMBL; ABJB010393513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS958199; EEC19267.1; -; Genomic_DNA.
DR RefSeq; XP_002415602.1; XM_002415557.1.
DR AlphaFoldDB; B7QK95; -.
DR PaxDb; 6945-B7QK95; -.
DR EnsemblMetazoa; ISCW014980-RA; ISCW014980-PA; ISCW014980.
DR GeneID; 8042518; -.
DR KEGG; isc:IscW_ISCW014980; -.
DR VEuPathDB; VectorBase:ISCI014980; -.
DR VEuPathDB; VectorBase:ISCP_021564; -.
DR VEuPathDB; VectorBase:ISCW014980; -.
DR HOGENOM; CLU_014743_0_2_1; -.
DR InParanoid; B7QK95; -.
DR OMA; DSPWHLI; -.
DR OrthoDB; 205363at2759; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IBA:GO_Central.
DR GO; GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR045473; ASM_C.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR PANTHER; PTHR10340:SF59; METALLOPHOS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10340; SPHINGOMYELIN PHOSPHODIESTERASE; 1.
DR Pfam; PF19272; ASMase_C; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EEC19267.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 417..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..237
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 250..381
FT /note="Sphingomyelin phosphodiesterase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19272"
SQ SEQUENCE 443 AA; 49497 MW; 669F5C9DA941F31A CRC64;
MCHLVPNRPG SGDIGPYGDA KCDAPRLLVE SAVAAMRSIE PNPDFVLWTG DNLPHVKDVL
WSEVYAEIRW LAQRLSEAFP GCPVVPTLGN HDCSPPNYMR PNNMSMFLFD AGFNELLPSS
SWSTFEKAGY YNWTVSGSLR LVCLNSILWY TGNRAPALER SAEDQLVWLH KQLREAQRLG
QKVFISGHVA PGFYSRAVSP EVGVSGLFQD GINEAYQDLI ADFTDVISGQ FFGHQHGNAF
VILSNANGRP VGSAQVAASV TPWTTSDKFN RRLSITTNPM VRLYKYNRTS TRLLDYTVYY
LDFDKANNHP NETPKWETLY TLTTQYGLPD ASTASMVNLS QRLNSSSELL DVYIGLATAF
KDEYPCDSFC RQVQLCSVLC SRAGPHRLCM PTSTDWECNA PSPEPATDRL TSYHENVLTG
VVLTFLVVVC LVVVVRTKWD MRM
//
