ID B7QLH5_IXOSC Unreviewed; 222 AA.
AC B7QLH5;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=peptide chain release factor N(5)-glutamine methyltransferase {ECO:0000256|ARBA:ARBA00012771};
DE EC=2.1.1.297 {ECO:0000256|ARBA:ARBA00012771};
DE Flags: Fragment;
GN Name=8043058 {ECO:0000313|EnsemblMetazoa:ISCW014867-PA};
GN ORFNames=IscW_ISCW014867 {ECO:0000313|EMBL:EEC19697.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC19697.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC19697.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW014867-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW014867-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-
CC methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release
CC factor] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42896, Rhea:RHEA-
CC COMP:10271, Rhea:RHEA-COMP:10272, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30011, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:61891; EC=2.1.1.297;
CC Evidence={ECO:0000256|ARBA:ARBA00000932};
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DR EMBL; ABJB010258253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS965314; EEC19697.1; -; Genomic_DNA.
DR RefSeq; XP_002416030.1; XM_002415985.1.
DR AlphaFoldDB; B7QLH5; -.
DR STRING; 6945.B7QLH5; -.
DR PaxDb; 6945-B7QLH5; -.
DR EnsemblMetazoa; ISCW014867-RA; ISCW014867-PA; ISCW014867.
DR GeneID; 8043058; -.
DR KEGG; isc:IscW_ISCW014867; -.
DR VEuPathDB; VectorBase:ISCI014867; -.
DR VEuPathDB; VectorBase:ISCP_024112; -.
DR VEuPathDB; VectorBase:ISCW014867; -.
DR HOGENOM; CLU_018398_4_1_1; -.
DR InParanoid; B7QLH5; -.
DR OMA; LGWAEFC; -.
DR OrthoDB; 1121774at2759; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004556; HemK-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR NCBIfam; TIGR00536; hemK_fam; 1.
DR PANTHER; PTHR18895; HEMK METHYLTRANSFERASE; 1.
DR PANTHER; PTHR18895:SF74; MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE; 1.
DR Pfam; PF05175; MTS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:EEC19697.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transferase {ECO:0000313|EMBL:EEC19697.1}.
FT DOMAIN 40..141
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC19697.1"
FT NON_TER 222
FT /evidence="ECO:0000313|EMBL:EEC19697.1"
SQ SEQUENCE 222 AA; 24800 MW; A38E3B832B47F72A CRC64;
SVHYRLPVQY ILGEWDFHNI TLKMQPPIFI PRPETENLVD IVLSHLKRTP KSSTVLDIGC
GTGAICLALG NAAQIHCTGV DKNPKAVKLS KENATNLNLA HCATFHEAEI SSHGIDTAYS
PLLNQVYDVI VSNPPYISTE EAKDLEPEVL RYEDHGALFA GPRGLDMVQN ILRYSRTNLR
VGGHLFLEVG LSHPPLIRNI LRTPEYNQLL RLHAVHSDFT LR
//
