ID B7QMD7_IXOSC Unreviewed; 448 AA.
AC B7QMD7;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Ubiquitin protein ligase E3 mdm2, putative {ECO:0000313|EMBL:EEC20009.1, ECO:0000313|EnsemblMetazoa:ISCW023507-PA};
GN ORFNames=IscW_ISCW023507 {ECO:0000313|EMBL:EEC20009.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC20009.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC20009.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW023507-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW023507-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MDM2/MDM4 family.
CC {ECO:0000256|ARBA:ARBA00005803, ECO:0000256|PIRNR:PIRNR006748}.
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DR EMBL; ABJB010002067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010666719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010883494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS970712; EEC20009.1; -; Genomic_DNA.
DR RefSeq; XP_002416342.1; XM_002416297.1.
DR AlphaFoldDB; B7QMD7; -.
DR STRING; 6945.B7QMD7; -.
DR PaxDb; 6945-B7QMD7; -.
DR EnsemblMetazoa; ISCW023507-RA; ISCW023507-PA; ISCW023507.
DR KEGG; isc:IscW_ISCW023507; -.
DR VEuPathDB; VectorBase:ISCI023507; -.
DR VEuPathDB; VectorBase:ISCP_036060; -.
DR VEuPathDB; VectorBase:ISCW023507; -.
DR HOGENOM; CLU_043544_2_0_1; -.
DR InParanoid; B7QMD7; -.
DR OMA; IPDCRRT; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR CDD; cd16646; mRING-HC-C2H2C4_MDM2-like; 1.
DR Gene3D; 1.10.245.10; SWIB/MDM2 domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR016495; p53_neg-reg_MDM_2/4.
DR InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR InterPro; IPR003121; SWIB_MDM2_domain.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46858:SF5; E3 UBIQUITIN-PROTEIN LIGASE MDM2; 1.
DR PANTHER; PTHR46858; OS05G0521000 PROTEIN; 1.
DR Pfam; PF02201; SWIB; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR PIRSF; PIRSF006748; p53_MDM_2/4; 3.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF47592; SWIB/MDM2 domain; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:EEC20009.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR006748};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR006748};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 291..310
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS01358"
FT REGION 121..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..342
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 448 AA; 50101 MW; 916607C37AF65C1F CRC64;
MVLCTNDKLG KVFGVEQFLA EEVKSLQLPN LQILGHLKSY ILERQLFDPK DPKMVLCAND
KLGKVFGVEQ FLAEEVKLQA CPWDAGLWLA GFGRRESAGR AENDLGSTTL AKAYRAGEKL
KRAATAGPSD AEDPKRARTE GQDAVTSSTP KRPSTPLVFF IPGSPEYDSG AESELSIQGH
ETDLVRDSTD YLWESEEEDN TKEGAAAMVA AVASHLSRLA GSDDEDCPFE VEYELESHSS
GDGNAYSTDS DIVDSAPVDV VICVEEDAGF FADSSDSSHS SDSEIGEEDL WECRLCETQN
TPLHRYCQKC WKRRFGWLPD RQEKHPPQKR RWRQRRERRH ERRSGKSTSS PIGRDDERKP
SPASLGSQGL TELRDLLEAG PSGVSQEVGS VQDPCSMCLV RPRTAILGHG KTSHRFGCYR
CSRKLLQQNK RCPICRRHID RVYHYFQD
//
