ID B7QNN1_IXOSC Unreviewed; 250 AA.
AC B7QNN1;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Purple acid phosphatase {ECO:0000256|RuleBase:RU361203};
DE EC=3.1.3.2 {ECO:0000256|RuleBase:RU361203};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW023969 {ECO:0000313|EMBL:EEC20453.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC20453.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC20453.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW023969-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW023969-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC Evidence={ECO:0000256|RuleBase:RU361203};
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. Purple
CC acid phosphatase family. {ECO:0000256|RuleBase:RU361203}.
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DR EMBL; ABJB010939674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS979495; EEC20453.1; -; Genomic_DNA.
DR RefSeq; XP_002416536.1; XM_002416491.1.
DR AlphaFoldDB; B7QNN1; -.
DR STRING; 6945.B7QNN1; -.
DR PaxDb; 6945-B7QNN1; -.
DR EnsemblMetazoa; ISCW023969-RA; ISCW023969-PA; ISCW023969.
DR KEGG; isc:IscW_ISCW023969; -.
DR VEuPathDB; VectorBase:ISCI023969; -.
DR VEuPathDB; VectorBase:ISCP_011077; -.
DR VEuPathDB; VectorBase:ISCW023969; -.
DR HOGENOM; CLU_088797_0_0_1; -.
DR InParanoid; B7QNN1; -.
DR OMA; NATHAFW; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd00839; MPP_PAPs; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 2.60.40.380; Purple acid phosphatase-like, N-terminal; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041792; MPP_PAP.
DR InterPro; IPR008963; Purple_acid_Pase-like_N.
DR InterPro; IPR015914; Purple_acid_Pase_N.
DR PANTHER; PTHR45867:SF3; ACID PHOSPHATASE TYPE 7; 1.
DR PANTHER; PTHR45867; PURPLE ACID PHOSPHATASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF16656; Pur_ac_phosph_N; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF49363; Purple acid phosphatase, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|RuleBase:RU361203, ECO:0000313|EMBL:EEC20453.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..78
FT /note="Purple acid phosphatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16656"
FT DOMAIN 89..249
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT NON_TER 250
FT /evidence="ECO:0000313|EMBL:EEC20453.1"
SQ SEQUENCE 250 AA; 28645 MW; 83F4CE114C8FA2B3 CRC64;
MIVTWTTFNE THESVVEFGQ GSLDQRAVGN NSTKFKDGGA EHRVIFIHRV TLTGLQPGSL
YRYHCGSNMG WSSLFFFRAM RSGQNWSPRL AVFGDMGNVN AQSLPFLQEE AQKGTIDAVL
HVGDFAYDMD SDNARVGDEF MRQIEPVAAY VPYMTCVGNH ENSYNFSNYV NRFSMVDKSG
NINNHFFSFD LGPAHIISFS TEFYFFVEYG YAQIANQYHW LEEDLKEATK PENRAKRPWI
ITMGHRPMYC
//
