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Database: UniProt
Entry: B7R5G0_9EURY
LinkDB: B7R5G0_9EURY
Original site: B7R5G0_9EURY 
ID   B7R5G0_9EURY            Unreviewed;      1361 AA.
AC   B7R5G0;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   19-FEB-2014, entry version 40.
DE   RecName: Full=Ribonucleoside-diphosphate reductase;
DE            EC=1.17.4.1;
GN   ORFNames=TAM4_1100;
OS   Thermococcus sp. AM4.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=246969;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AM4;
RA   Bartlett D., Bonch-Osmolovskaya E., Ferriera S., Johnson J.,
RA   Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R.,
RA   Frazier M., Venter J.C.;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AM4;
RX   PubMed=22123768; DOI=10.1128/JB.06259-11;
RA   Oger P., Sokolova T.G., Kozhevnikova D.A., Chernyh N.A.,
RA   Bartlett D.H., Bonch-Osmolovskaya E.A., Lebedinsky A.V.;
RT   "Complete Genome Sequence of the Hyperthermophilic Archaeon
RT   Thermococcus sp. Strain AM4, Capable of Organotrophic Growth and
RT   Growth at the Expense of Hydrogenogenic or Sulfidogenic Oxidation of
RT   Carbon Monoxide.";
RL   J. Bacteriol. 193:7019-7020(2011).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AM4;
RA   Oger P.M., Solokova T.G., Kozhevnikova D.A., Chernyh N.A.,
RA   Bartlett D.H., Bonch-Osmoloskaya E.A., Lebedinsky A.V.;
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Provides the precursors necessary for DNA synthesis.
CC       Catalyzes the biosynthesis of deoxyribonucleotides from the
CC       corresponding ribonucleotides (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2'-deoxyribonucleoside diphosphate +
CC       thioredoxin disulfide + H(2)O = ribonucleoside diphosphate +
CC       thioredoxin.
CC   -!- PATHWAY: Genetic information processing; DNA replication.
CC   -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase
CC       large chain family.
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DR   EMBL; CP002952; EEB72993.1; -; Genomic_DNA.
DR   RefSeq; YP_002581290.1; NC_016051.1.
DR   EnsemblBacteria; EEB72993; EEB72993; TAM4_1100.
DR   GeneID; 7419508; -.
DR   KEGG; tha:TAM4_1100; -.
DR   KO; K00525; -.
DR   UniPathway; UPA00326; -.
DR   GO; GO:0005971; C:ribonucleoside-diphosphate reductase complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR   GO; GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
DR   Gene3D; 3.10.28.10; -; 2.
DR   Gene3D; 3.30.160.90; -; 1.
DR   InterPro; IPR005144; ATP-cone.
DR   InterPro; IPR003586; Hint_dom_C.
DR   InterPro; IPR003587; Hint_dom_N.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR006142; INTEIN.
DR   InterPro; IPR004042; Intein_endonuc.
DR   InterPro; IPR006141; Intein_splice_site.
DR   InterPro; IPR015147; PI-PfuI_intein_endonucl_subdom.
DR   InterPro; IPR000788; RNR_lg_C.
DR   InterPro; IPR013509; RNR_lsu_N.
DR   InterPro; IPR013344; RNR_NrdJ/NrdZ.
DR   InterPro; IPR008926; RNR_R1-su_N.
DR   InterPro; IPR015146; RNR_stirrup.
DR   Pfam; PF03477; ATP-cone; 1.
DR   Pfam; PF09062; Endonuc_subdom; 1.
DR   Pfam; PF14528; LAGLIDADG_3; 1.
DR   Pfam; PF02867; Ribonuc_red_lgC; 2.
DR   Pfam; PF00317; Ribonuc_red_lgN; 1.
DR   Pfam; PF09061; Stirrup; 1.
DR   PRINTS; PR00379; INTEIN.
DR   PRINTS; PR01183; RIBORDTASEM1.
DR   SMART; SM00305; HintC; 1.
DR   SMART; SM00306; HintN; 1.
DR   SUPFAM; SSF48168; SSF48168; 1.
DR   SUPFAM; SSF54786; SSF54786; 1.
DR   SUPFAM; SSF55608; SSF55608; 2.
DR   TIGRFAMs; TIGR01443; intein_Cterm; 1.
DR   TIGRFAMs; TIGR01445; intein_Nterm; 1.
DR   TIGRFAMs; TIGR02504; NrdJ_Z; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
DR   PROSITE; PS50818; INTEIN_C_TER; 1.
DR   PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR   PROSITE; PS50817; INTEIN_N_TER; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA replication; Oxidoreductase.
SQ   SEQUENCE   1361 AA;  155974 MW;  AE3C281794142A71 CRC64;
     MAVEKVMKRD GRIVPFDRER IKWAIKRAML EVGVHDDKLL NRVVRRVVRR INELYDGQVP
     HIENIQDIVE LELMRAGLFE VAKAYILYRK KKAEIREEKK KILNKDKLDE IDKRFSLNAL
     RVLASRYLIR NEKGEIVESP RELFERVATL AVIPDLLYDE RVYDKEGKHE QDLSRVKHYL
     EHFEEFDGKY SIGRFKLNKY HFERLVKLYR ELAEKGKMKV SIDEFLGMLE NGAFDDYESE
     IEEYFRLMTS QTFMPNTPAL INSGRPLGML SACFVVPIED DMESIMKAAH DVAMIQKSGG
     GCIDGNAKIL FENEGEEHLT TMAEMYERYK HLGEFYDKNY NRWGIDVSSV PIYVKSFDPE
     TGEVVRGRVK AIWRYELGEK VTKYNIKTNK GTRILTSPWH PFFVLNPDFK VVEKRADELS
     EGDMLVGGMP EDDNHEFIFD YWLAGFIAGD GSFDKQRSHV KGHEYIYDRL RIYDYRVETF
     ETINKYLEET FGKRYSLQRD RNIYYIDIKA REITSHYRKL LDGIDTGIPP EILRKGRAAV
     LSFITGLFDA EGHVNSKPGV ELGMVNRKLI EDIAHYLSSL GIKARMREKP RKDGVDYIVH
     VEEYSSLLRF YELIGKNLQN EEKRKKLETL LEKHKGGTFG LSLNFEAFKR WASKHGVEFK
     TNGSQTLAII KGEKISLGQW HTRGRVSKAV LVKMLRKLYD ATGVEDVKRM LHLVEGLEVV
     KEITTTNEPK TFYDLTVENY QNYLAGENGM VFVHNTGLNF SKLRPEGDFV GSTAGAASGP
     VSFMHLIDAV SDVIKQGGVR RGANMGILEV WHPDIEKFIH AKERNTGTNV LSNFNISVGI
     WEDFWEALKE GKRYPLVNPR TGEKVKEIDP KSLFEELAFM AWSKADPGVI FFDVINRRNV
     LAEAKGGPIR ATNPCGEEPL YEYESCNLAS INLAKFVKYD DEGKPYFDWD EYAYVIQKVA
     KYLDNAIDVN RFPLPEIDHN TKLTRRIGVG MMGLADALFK LGIPYNSEEG FAFMRKATEY
     LTFYAYKYSV EAAKKRGTFP LYEKSAYKDG ELPVEGFYHR EIWTLPWDEL VEEIKRHGVR
     NGMVTTCPPT GSVSMIADTS SGIEPIFALV YKKSVTVGEF YYVDPVFESE LKKRGLWSDE
     ILRKISDNYG SVQGLEEIPE DMQRVFVTSM DVHWLDHILA QANIQLWLTD SASKTINMPN
     DATVEDVKAA YLLAYKLGCK GITVYRDGSL SVQVYSVEGE KRKRVPAKPS SYAVEKLKAV
     VEAEPWLAKF INVEAILNGT NGKEKPQLSF SLSTAKAVTP KTPEHPHHAE KPEVPEEKIK
     ELLGVAYCPV CYEKDGELVE LRMESGCATC PRCGWSKCVI S
//
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