ID B7R905_9THEO Unreviewed; 778 AA.
AC B7R905;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Nucleoside-diphosphate-sugar pyrophosphorylase {ECO:0000313|EMBL:KKC29025.1};
GN ORFNames=CDSM653_01876 {ECO:0000313|EMBL:KKC29025.1};
OS Caldanaerobacter subterraneus subsp. pacificus DSM 12653.
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Caldanaerobacter.
OX NCBI_TaxID=391606 {ECO:0000313|EMBL:KKC29025.1, ECO:0000313|Proteomes:UP000010146};
RN [1] {ECO:0000313|EMBL:KKC29025.1, ECO:0000313|Proteomes:UP000010146}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12653 {ECO:0000313|EMBL:KKC29025.1,
RC ECO:0000313|Proteomes:UP000010146};
RA Gonzalez J., Sokolova T., Ferriera S., Johnson J., Kravitz S., Beeson K.,
RA Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KKC29025.1, ECO:0000313|Proteomes:UP000010146}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12653 {ECO:0000313|EMBL:KKC29025.1,
RC ECO:0000313|Proteomes:UP000010146};
RX PubMed=26446804; DOI=10.1186/s12864-015-1955-9;
RA Sant'Anna F.H., Lebedinsky A.V., Sokolova T.G., Robb F.T., Gonzalez J.M.;
RT "Analysis of three genomes within the thermophilic bacterial species
RT Caldanaerobacter subterraneus with a focus on carbon monoxide dehydrogenase
RT evolution and hydrolase diversity.";
RL BMC Genomics 16:757-757(2015).
RN [3] {ECO:0000313|Proteomes:UP000010146}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12653 {ECO:0000313|Proteomes:UP000010146};
RA Sant'Anna F.H., Lebedinsky A., Sokolova T., Robb F.T., Gonzalez J.M.;
RT "Genome analysis of three genomes within the thermophilic hydrogenogenic
RT bacterial species Caldanaerobacter subterraneus.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the phosphohexose mutase family.
CC {ECO:0000256|ARBA:ARBA00010231}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKC29025.1}.
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DR EMBL; ABXP02000106; KKC29025.1; -; Genomic_DNA.
DR RefSeq; WP_009610756.1; NZ_ABXP02000106.1.
DR AlphaFoldDB; B7R905; -.
DR Proteomes; UP000010146; Unassembled WGS sequence.
DR GO; GO:0016868; F:intramolecular phosphotransferase activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd03356; LbH_G1P_AT_C_like; 1.
DR CDD; cd04181; NTP_transferase; 1.
DR Gene3D; 3.40.120.10; Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3; 1.
DR Gene3D; 3.30.310.50; Alpha-D-phosphohexomutase, C-terminal domain; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 2.
DR InterPro; IPR005844; A-D-PHexomutase_a/b/a-I.
DR InterPro; IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
DR InterPro; IPR036900; A-D-PHexomutase_C_sf.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR PANTHER; PTHR22572:SF15; MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA; 1.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR Pfam; PF02878; PGM_PMM_I; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF55957; Phosphoglucomutase, C-terminal domain; 1.
DR SUPFAM; SSF53738; Phosphoglucomutase, first 3 domains; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..228
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 381..501
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02878"
SQ SEQUENCE 778 AA; 88748 MW; 4FBD44966C6AE47E CRC64;
MKGIIMAGGE GSRLRPLTFD IPKPLVPVAN KPAIKHIVEH LHKYGVGELA VTLFYLPHKI
KDYLLEEYGN EIKFYTEEKP LGTAGSVKNA KDFLKETFIV MSGDVITDVN IKEVYDFHRK
KGSKVTLVLK KVEIPLEYGV VIVDETGKIV KFLEKPSWGE VFSDTVNTGI YIIEPEILEF
IPEDRPFDFS KDLFPLLLKE NIPMYGYITE GYWCDIGNTA QYLSSHFDVL EGKLDLGYRK
ILLEEGKVIG KKVLMSSGAK LILPLIIGNE VVIEENAVVG PNVVIGRGTI IKKGSHVKNS
VLWEDVYVGE NSELNGAVVC NKVRIDSNAR ILENAVIGER VRIKAFAEIR PDVKVWPFKV
IEEEAVVSKD VVWGNGRKNL SFGYRGIRGI FNEEIGPYQA VEIGEAFGDL MKGKVIVGSD
EELASSLIAD LIAYGLAFSG CEVLKSNSFL LPALRVGIRL RSAKGGVYVE RIGEEIRILF
LDGEGMDIDR NLEKKIENKL KIHDISRRKI EDIKPIKEVD VEGDYKDYLV KNRADSFKIK
VKPHDEWTKK VLLQIKGEQI LDDQNYHLKV KLKKNGEEIE LYDEKDRKFD EDEVNYLKML
IAREKGLKKV VLPFNSSKYL AEFAEELAVE TVVGKISPRD LMRSMTNLEE GRQVYFDLSF
DGINFLLEVI EYVRLKNKRL SEIKDSFPLR YKTVKRIRCD WKDKGRIIRE LFETRKNNVT
FLDGLRFEED EGWVLVVPDS ELPFCNVYVE ALTPEKAERL FTIYEKKIQD ILLKNDGK
//
