ID B7RXI8_9GAMM Unreviewed; 705 AA.
AC B7RXI8;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Peptidase families S8 and S53 domain protein {ECO:0000313|EMBL:EEB78744.1};
GN ORFNames=GPB2148_1952 {ECO:0000313|EMBL:EEB78744.1};
OS marine gamma proteobacterium HTCC2148.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae.
OX NCBI_TaxID=247634 {ECO:0000313|EMBL:EEB78744.1, ECO:0000313|Proteomes:UP000002793};
RN [1] {ECO:0000313|Proteomes:UP000002793}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTCC2148 {ECO:0000313|Proteomes:UP000002793};
RX PubMed=20472793; DOI=10.1128/jb.00511-10;
RA Thrash J.C., Cho J.C., Ferriera S., Johnson J., Vergin K.L.,
RA Giovannoni S.J.;
RT "Genome sequences of strains HTCC2148 and HTCC2080, belonging to the
RT OM60/NOR5 clade of the Gammaproteobacteria.";
RL J. Bacteriol. 192:3842-3843(2010).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS999226; EEB78744.1; -; Genomic_DNA.
DR AlphaFoldDB; B7RXI8; -.
DR STRING; 247634.GPB2148_1952; -.
DR eggNOG; COG1404; Bacteria.
DR eggNOG; COG3291; Bacteria.
DR HOGENOM; CLU_011263_15_3_6; -.
DR Proteomes; UP000002793; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07477; Peptidases_S8_Subtilisin_subset; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR034202; Subtilisin_Carlsberg-like.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF00082; Peptidase_S8; 2.
DR Pfam; PF18911; PKD_4; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS50093; PKD; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000002793};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..705
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002863404"
FT DOMAIN 552..632
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT ACT_SITE 149
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 189
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 480
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 705 AA; 71945 MW; 7C5C95B26BFF8AFA CRC64;
MKHIKRPITH PQFVNSLYQL TAAFLCSMMV MSANADDSRF IIQVDEANKG LVKALSKRAG
GRLKLEARGF FAAEFPGRSL NDVRGLVNNP HVISIEEDFR RFPMGFADEG ANPMTSQVIP
YAIIQSQADQ LQSELSPGDL MSQKVCVIDS GIAGSQGETG GLNSDFDWNV ITGDSDSGTG
YWGSDGGPHG THVAGTIAAA DNTVGVIGMA PGVPLHIIKV FNAAGWGYSS DLAYAAQNCA
QAGANIISMS LGGGGSNNAE RNAFDSFTAD GGLVLAAAGN DGNNVVSYPA GYESVMMVGA
NDADNNIASF SQYPTCTQTT GRGKKRTTVV KDGICVEISA GGVNTLSTYP AGGASVAIAS
LDGTSLAVAA MENQGAAEAA VYGFGIGNSQ DPGADGKICA IDRGSISFYD KVNNCEGSGG
VGAIVVNNEP GALFATLGDA NDTSIPAVGA AQSDRSAVFG ATNAAITIGA GDFGYMSGTS
MATPAVAGVA ALVWSQHANC TGEDIRNALK QSAQDAGAPG KDLYHGYGIV QAKAASVWLE
QNSSCGGGGG GGDNPPTASF SQSCTLLTCE FTDTSVDDVG IATRAWNFGD GNSNTQSSTT
HTYAASGTYT VTLTVTDTTG QISSQPEAVT VTDGGGGGGS DYTVATYNAG RNWYAVVSSP
DGVWGSFDNG ANCDGGTTCQ SNQQRKKSGT MVFSPSSGDP ITIIW
//
