ID B7U5S4_9PICO Unreviewed; 2249 AA.
AC B7U5S4;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS Duck hepatitis A virus 1.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Paavivirinae; Avihepatovirus;
OC Avihepatovirus A.
OX NCBI_TaxID=1006061 {ECO:0000313|EMBL:ACJ63291.1, ECO:0000313|Proteomes:UP000110671};
RN [1] {ECO:0000313|EMBL:ACJ63291.1, ECO:0000313|Proteomes:UP000110671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LY0801 {ECO:0000313|EMBL:ACJ63291.1};
RA Gao J.M., Jiang S.J., Zhang X.X., Wang B., Liu B., Liu S.N.;
RT "Molecular analysis of Duck hepatitis virus 1 of strain LY0801.";
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Host cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004295}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004295}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004295}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; FJ436047; ACJ63291.1; -; Genomic_RNA.
DR Proteomes; UP000110671; Genome.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039618; C:T=pseudo3 icosahedral viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0039707; P:virus-mediated pore formation in host cell membrane; IEA:UniProtKB-KW.
DR CDD; cd23193; ps-ssRNA_Picornaviridae; 1.
DR CDD; cd00205; rhv_like; 2.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 2.60.120.20; -; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR045058; GIMA/IAN/Toc.
DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR PANTHER; PTHR10903:SF135; GTP-BINDING PROTEIN A; 1.
DR PANTHER; PTHR10903; GTPASE, IMAP FAMILY MEMBER-RELATED; 1.
DR Pfam; PF04548; AIG1; 1.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00073; Rhv; 1.
DR Pfam; PF00910; RNA_helicase; 1.
DR PRINTS; PR00918; CALICVIRUSNS.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00022488};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW T=pseudo3 icosahedral capsid protein {ECO:0000256|ARBA:ARBA00022706};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral ion channel {ECO:0000256|ARBA:ARBA00023039};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022706};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 1270..1432
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1610..1795
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 2014..2129
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 250..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2249 AA; 252701 MW; A3B03EAC7665270B CRC64;
MDTLTKNIED ATVYIIGSCA EKVEEAISGL GAVESVASTN SAIATANATT TQTIPDPTEG
STDDFYSCSY EVGAQGDNIS RLVHLVTGQW IPNDDYYACL RWLATPACFF QNNTQPAYGQ
TRYFRFIRCG FHFRLLVNAP SGSAGALMLV WMPYPYCRVL SGTNQIHANV ERRSLMNLPY
AILDLRTNTE IDLVVPYVNY RNYVEITTSD TTGGAICVIV LGKYRHGNGT SNTVDFTLFG
ELLETDLQCP RPFDNQGKRK PRRRPIHKPK NPPQEPRVII QPGPGAANPS NSSVIAMAES
TALANEGTAV DYSTAGCASS VDDVIMVLRR WQILASFQWQ STLTPSVRIN RYQLIFRNIP
TFSLFFDKFQ YWRGSLEVKF MTFGSQFNTG RYQMSWYPIA DGEQSLAQCQ NSVFVTGDVC
AIPVTLTLPF TSTTWRKSTR GPYEYLMWHV VNRLTVNSSA PSNIDCTVLL RVGKDFQFTA
PLYGNLQMAT NNQGDSNQLG DDEPVCFLNF ETANVPIQGE SHTLVKHLFG RQWLVRTVQH
TSTVQELDLQ VPDRGHASLI RFFAYFSGEI ILTIVNNGTT PAMVAHSYSM DDLTSEYAVT
AMGGVMIPAN SAKNISVPFY SVTPLRPTRP IPGTSEATFG RLFMWTQSGS LSVFMGLKKP
ALFFPLPAPT STTSSRESNG VIPTLDQSGD EVDCHFCEIC SKMKRMWKPR GHFRFCLRLK
TLAFELNLEI ESDQIRNKKD LTTEGVEPNP GPILVVGKSG SGKSRLCNVL AGVELFESKL
SPRSVTMVHQ VETIDIEGKK VTIVDSPETP NYDGPISAFF YLIEAGRFTA EDKEYIQMMR
KRFPGFEKST ILILNRADEL KTDDDIRNWV KTSGELDSLV RACGGRIAKF HRHKINRAKL
LEKAATLPEF VSHLPRLVYK DRKMYRHYGV QCGSTVFHMD SENILESALN GEVTIKQEKW
NGNWKPAGDH MQSTASMYLK SQTMPKFTFS IDENCETWAR HLLGDYGETQ GQIFKERLMW
AAALGFFMTM KITTDQSFPG KDAIHTVLTK ISNFIFGGLE NEVVRVVIRT VIRIVCYLIL
YIHSPNIVTT GTLVALLALD ATSMSMDQGL KTLCMSLVDG DFGKFCSALL EKIQTVDEAD
LKKTIPKFND MLEDQSGKTT SPKSFNDWTT CAKNVQWWLE SFVKVINWLK EKVFPSKTDP
TLQWLQDHEE HIAIMLALCD EHLCMLRTEK DYICEHNTRP KHQRLVEMVS GTLNQLQGIS
SARELAARLQ HVLNKLHQVN FEPELEWTHR PEPLGIWISG GPGVGKSFLS NYIVKEIAKL
KHWRSYANPT GSKHMDGYVS QEIHAFDDFG QNREEEDYSL ICNLISSVPF ITPKASVEAK
GTQYRGRLVV VTTNRRDFTS CKLTDPDALE RRFPIRLNIR PLQKYNHKGR LDAATAMRDG
SLQGGTCWER DIGQLGLECW NPINGQTLID EIMSELQVRQ EVASFMNQSK VRRFSDPETL
FSDLEDLKLE FDFDQLEQQA KLFAKPKEGK ISKFRAWVRD CTGKIKGFLE RNRAWILGIG
TLGTIVSLVT MCVPLARRFA QSIYSQQPVA KTLPKDFKVA VKKHIEKLET ELEDQSGRVN
FRHICNRLVN VSNEDEVATG LAIGGKNVLT FGHSKFTQLD EIRDMQFNAP AKGTPITYDG
EPTDLQLLEC DIPHQFKDVS KLIATEDYRG NGWLVWKDQD QYMVQDVTKI RPFGSTTTAS
GTTSCQTYIY NCKTGPGSCG GVLVAQIGGN LKILGIHTSG NGTMGAANRV FPVFNQGKVV
SKQYAGKILY HQPRKTAYMR SPVYEDSPYE PAVLSINDQR LGVKIEDMAK KASDKYIGNV
FQPPPEAFQL AKTHVAEKLS RVLGCHDTIS YESAVSSDVI PMNWDTSPGI KYKGETKRQL
VLKSSFRQDV MEQLQSPSTV FTCYLKDELR KKEKIKEGKT RGIEACNFDH TVAYRMVMGD
IFSNIYDDSF IISGCAVGIN PFCEWDNLLA NLQPYNLCLD FSGFDGSLSA QILEEAVDVL
LYFHNDPALV KRIHAPTNYS THYVTDEIWQ VEGGMCSGSP CTTVVNSIVN QLACYTILAV
LGYDINQCYV VSYGDDCVLS APEVRDISKL SHYFKLFFGM TATASDKESD ITWLAPMEIE
FLKRTPAFLP GTRKIIGVLD KEVLEGKIQW CKGPEAFKQQ LDSFLLEAAL HGEEYYHEVT
FKLKARCPVL DIQPWGVAKL RAYTACMMI
//
