ID B7UP85_ECO27 Unreviewed; 97 AA.
AC B7UP85;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Negative regulator of flagellin synthesis {ECO:0000256|ARBA:ARBA00017823};
DE AltName: Full=Anti-sigma-28 factor {ECO:0000256|ARBA:ARBA00030117};
GN Name=flgM {ECO:0000313|EMBL:CAS08709.1};
GN OrderedLocusNames=E2348C_1161 {ECO:0000313|EMBL:CAS08709.1};
OS Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS08709.1, ECO:0000313|Proteomes:UP000008205};
RN [1] {ECO:0000313|EMBL:CAS08709.1, ECO:0000313|Proteomes:UP000008205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX PubMed=18952797; DOI=10.1128/JB.01238-08;
RA Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R.,
RA Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A.,
RA Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.;
RT "Complete genome sequence and comparative genome analysis of
RT enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL J. Bacteriol. 191:347-354(2009).
CC -!- FUNCTION: Responsible for the coupling of flagellin expression to
CC flagellar assembly by preventing expression of the flagellin genes when
CC a component of the middle class of proteins is defective. It negatively
CC regulates flagellar genes by inhibiting the activity of FliA by
CC directly binding to FliA. {ECO:0000256|ARBA:ARBA00024739}.
CC -!- SIMILARITY: Belongs to the FlgM family.
CC {ECO:0000256|ARBA:ARBA00005322}.
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DR EMBL; FM180568; CAS08709.1; -; Genomic_DNA.
DR RefSeq; WP_000020884.1; NC_011601.1.
DR AlphaFoldDB; B7UP85; -.
DR KEGG; ecg:E2348C_1161; -.
DR HOGENOM; CLU_149304_2_2_6; -.
DR Proteomes; UP000008205; Chromosome.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR InterPro; IPR035890; Anti-sigma-28_factor_FlgM_sf.
DR InterPro; IPR007412; FlgM.
DR InterPro; IPR031316; FlgM_C.
DR NCBIfam; TIGR03824; FlgM_jcvi; 1.
DR Pfam; PF04316; FlgM; 1.
DR SUPFAM; SSF101498; Anti-sigma factor FlgM; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|ARBA:ARBA00022795};
KW Reference proteome {ECO:0000313|Proteomes:UP000008205};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 40..88
FT /note="Anti-sigma-28 factor FlgM C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04316"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 97 AA; 10355 MW; 30A0B463324FE34D CRC64;
MSIDRTSPLK PVSTVQPRET TDAPVTNTRA AKTTASTSTS VTLSDAQAKL MQPGSSDINL
ERVEALKLAI RNGELKMDTG KIADALINEA QQDLQSN
//
