ID B7UPT7_ECO27 Unreviewed; 547 AA.
AC B7UPT7;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Predicted metal dependent hydrolase EptA {ECO:0000313|EMBL:CAS11990.1};
GN Name=eptA {ECO:0000313|EMBL:CAS11990.1};
GN OrderedLocusNames=E2348C_4442 {ECO:0000313|EMBL:CAS11990.1};
OS Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS11990.1, ECO:0000313|Proteomes:UP000008205};
RN [1] {ECO:0000313|EMBL:CAS11990.1, ECO:0000313|Proteomes:UP000008205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX PubMed=18952797; DOI=10.1128/JB.01238-08;
RA Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R.,
RA Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A.,
RA Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.;
RT "Complete genome sequence and comparative genome analysis of
RT enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL J. Bacteriol. 191:347-354(2009).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FM180568; CAS11990.1; -; Genomic_DNA.
DR RefSeq; WP_001346549.1; NC_011601.1.
DR AlphaFoldDB; B7UPT7; -.
DR KEGG; ecg:E2348C_4442; -.
DR HOGENOM; CLU_018534_1_0_6; -.
DR Proteomes; UP000008205; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR CDD; cd16017; LptA; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR012549; EptA-like_N.
DR InterPro; IPR040423; PEA_transferase.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR30443; INNER MEMBRANE PROTEIN; 1.
DR PANTHER; PTHR30443:SF0; PHOSPHOETHANOLAMINE TRANSFERASE EPTA; 1.
DR Pfam; PF08019; EptA_B_N; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:CAS11990.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008205};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..209
FT /note="Phosphoethanolamine transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08019"
FT DOMAIN 238..527
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
SQ SEQUENCE 547 AA; 61661 MW; F762460447A316E8 CRC64;
MLKRLLKRPS LNLFSWLLLA TFYISVCLNI AFFKQVLQVL PLDSLHNVLV FLSMPVVAFS
VINIVLTLGS FLWLNRPLAC LFILVGAAAQ YFIMTYGIVI DRSMITNIID TTPAESYALM
TPRMLLTLGL SGVLAAIIAC WIKIKSTTSR LRSVLFRGAN ILISVLLILL VAALFYKDYA
SLFRNNKELV KSLSPSNSIV ASWSWYSHQR SANLPLIRIG EDAHRNPLMQ NGKRKNLTIL
IVGETSRAEN FSLNGYPRET NPRLAKDNVV YFPNTASCGT ATAVSVPCMF SDMPREHYKE
ELAQHQEGVL DIIQRAGINV LWNDNDGGCK GVCDRVPHQN VTALNLPGQC INGECYDEVL
FHGLEDYINN LQGDGVIVLH TIGSHGPTYY NRYPPQFRKF TPTCDTNEIQ TCTQEQLVNT
YDNTLVYVDY IVDKAINLLK EHQDKFTTSL VYLSDHGESL GENGIYLHGL PYAIAPDSQK
QVPMLLWLSE DYQKRYQVDQ NCLQKQAQTQ HYSQDNLFST LLGLTGVETK YYQAADDILQ
TCRRVSE
//
