ID B7USU3_ECO27 Unreviewed; 468 AA.
AC B7USU3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Flagellar hook-associated protein 2 {ECO:0000256|ARBA:ARBA00016246, ECO:0000256|RuleBase:RU362066};
DE Short=HAP2 {ECO:0000256|RuleBase:RU362066};
DE AltName: Full=Flagellar cap protein {ECO:0000256|RuleBase:RU362066};
GN Name=fliD {ECO:0000313|EMBL:CAS09590.1};
GN OrderedLocusNames=E2348C_2042 {ECO:0000313|EMBL:CAS09590.1};
OS Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS09590.1, ECO:0000313|Proteomes:UP000008205};
RN [1] {ECO:0000313|EMBL:CAS09590.1, ECO:0000313|Proteomes:UP000008205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX PubMed=18952797; DOI=10.1128/JB.01238-08;
RA Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R.,
RA Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A.,
RA Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.;
RT "Complete genome sequence and comparative genome analysis of
RT enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL J. Bacteriol. 191:347-354(2009).
CC -!- FUNCTION: Required for morphogenesis and for the elongation of the
CC flagellar filament by facilitating polymerization of the flagellin
CC monomers at the tip of growing filament. Forms a capping structure,
CC which prevents flagellin subunits (transported through the central
CC channel of the flagellum) from leaking out without polymerization at
CC the distal end. {ECO:0000256|RuleBase:RU362066}.
CC -!- FUNCTION: Required for the morphogenesis and for the elongation of the
CC flagellar filament by facilitating polymerization of the flagellin
CC monomers at the tip of growing filament. Forms a capping structure,
CC which prevents flagellin subunits (transported through the central
CC channel of the flagellum) from leaking out without polymerization at
CC the distal end. {ECO:0000256|ARBA:ARBA00025175}.
CC -!- SUBUNIT: Homopentamer. {ECO:0000256|ARBA:ARBA00011255,
CC ECO:0000256|RuleBase:RU362066}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362066}.
CC Bacterial flagellum {ECO:0000256|RuleBase:RU362066}.
CC -!- SIMILARITY: Belongs to the FliD family. {ECO:0000256|ARBA:ARBA00009764,
CC ECO:0000256|RuleBase:RU362066}.
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DR EMBL; FM180568; CAS09590.1; -; Genomic_DNA.
DR RefSeq; WP_000146770.1; NC_011601.1.
DR AlphaFoldDB; B7USU3; -.
DR SMR; B7USU3; -.
DR GeneID; 66674186; -.
DR KEGG; ecg:E2348C_2042; -.
DR HOGENOM; CLU_015182_8_1_6; -.
DR Proteomes; UP000008205; Chromosome.
DR GO; GO:0009421; C:bacterial-type flagellum filament cap; IEA:InterPro.
DR GO; GO:0009424; C:bacterial-type flagellum hook; IEA:UniProtKB-UniRule.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR InterPro; IPR040026; FliD.
DR InterPro; IPR010809; FliD_C.
DR InterPro; IPR003481; FliD_N.
DR PANTHER; PTHR30288; FLAGELLAR CAP/ASSEMBLY PROTEIN FLID; 1.
DR PANTHER; PTHR30288:SF0; FLAGELLAR HOOK-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF07195; FliD_C; 1.
DR Pfam; PF02465; FliD_N; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum {ECO:0000256|ARBA:ARBA00023143,
KW ECO:0000256|RuleBase:RU362066};
KW Cell projection {ECO:0000313|EMBL:CAS09590.1};
KW Cilium {ECO:0000313|EMBL:CAS09590.1};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Flagellum {ECO:0000313|EMBL:CAS09590.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008205};
KW Secreted {ECO:0000256|RuleBase:RU362066}.
FT DOMAIN 11..106
FT /note="Flagellar hook-associated protein 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02465"
FT DOMAIN 222..452
FT /note="Flagellar hook-associated protein 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07195"
SQ SEQUENCE 468 AA; 48496 MW; E47B1418990984C2 CRC64;
MASISSLGVG SGLDLSSILD SLTAAQKATL TPISNQQSSF TAKLSAYGTL KSALTTFQTA
NTALSKADLF SATSTTSSTT AFSATTAGNA IAGKYTISVT HLAQAQTLTT RTTRDDTKTA
IATSDSKLTI QQGGDKDPIS IDISAANSSL SGIRDAINNA KAGVSASIIN VGNGEYRLSV
TSNDTGLDNA MTLSVSGDDA LQSFMGYDAS ASSNGMEVSV AAQNAQLTVN NVAIENSSNT
ISDALENITL NLNDVTTGNQ TLTITQDTSK AQTAIKDWVN AYNSLIDTFS SLTKYTAVDA
GADSQNSSNG ALLGDSTLRT IQTQLKSMLS NTVSSSNYKT LAQIGITTDP SDGKLELDAD
KLTAALKKDA SGVGALIVGD GKKTGITTTI GSNLTSWLST TGIIKAATDG VSKTLNKLTK
DYNAASDRID AQVARYKEQF TQLDVLMTSL NSTSSYLTQQ FENNSNSK
//