ID B7XKA8_ENTBH Unreviewed; 289 AA.
AC B7XKA8;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Aspartate-ammonia ligase {ECO:0000313|EMBL:EED43618.1};
DE EC=6.3.1.1 {ECO:0000313|EMBL:EED43618.1};
GN ORFNames=EBI_22021 {ECO:0000313|EMBL:EED41932.1}, EBI_24161
GN {ECO:0000313|EMBL:EED43618.1};
OS Enterocytozoon bieneusi (strain H348) (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Enterocytozoonidae;
OC Enterocytozoon.
OX NCBI_TaxID=481877 {ECO:0000313|EMBL:EED43618.1, ECO:0000313|Proteomes:UP000001742};
RN [1] {ECO:0000313|EMBL:EED43618.1, ECO:0000313|Proteomes:UP000001742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H348 {ECO:0000313|EMBL:EED43618.1,
RC ECO:0000313|Proteomes:UP000001742};
RX PubMed=18060071; DOI=10.1371/journal.pone.0001277;
RA Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S.,
RA Keeling P.J.;
RT "Patterns of genome evolution among the microsporidian parasites
RT Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon
RT bieneusi.";
RL PLoS ONE 2:E1277-E1277(2007).
RN [2] {ECO:0000313|EMBL:EED43618.1, ECO:0000313|Proteomes:UP000001742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H348 {ECO:0000313|EMBL:EED43618.1,
RC ECO:0000313|Proteomes:UP000001742};
RX PubMed=19132089; DOI=10.1371/journal.ppat.1000261;
RA Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N.,
RA Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.;
RT "Genomic survey of the non-cultivatable opportunistic human pathogen,
RT Enterocytozoon bieneusi.";
RL PLoS Pathog. 5:E1000261-E1000261(2009).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EED43618.1}.
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DR EMBL; ABGB01001227; EED41932.1; -; Genomic_DNA.
DR EMBL; ABGB01000050; EED43618.1; -; Genomic_DNA.
DR RefSeq; XP_002650436.1; XM_002650390.1.
DR RefSeq; XP_002652124.1; XM_002652078.1.
DR AlphaFoldDB; B7XKA8; -.
DR VEuPathDB; MicrosporidiaDB:EBI_22021; -.
DR VEuPathDB; MicrosporidiaDB:EBI_24161; -.
DR HOGENOM; CLU_071543_1_0_1; -.
DR InParanoid; B7XKA8; -.
DR OrthoDB; 143767at2759; -.
DR Proteomes; UP000001742; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004071; F:aspartate-ammonia ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006529; P:asparagine biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004618; AsnA.
DR PANTHER; PTHR30073; ASPARTATE--AMMONIA LIGASE; 1.
DR PANTHER; PTHR30073:SF5; ASPARTATE--AMMONIA LIGASE; 1.
DR Pfam; PF03590; AsnA; 1.
DR PIRSF; PIRSF001555; Asp_ammon_ligase; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Asparagine biosynthesis {ECO:0000256|ARBA:ARBA00022888};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EED43618.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001742}.
FT DOMAIN 58..274
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
SQ SEQUENCE 289 AA; 33084 MW; B0F62591AF49C985 CRC64;
MSGVNDDLNG EEPVRFQTSD GEWCSVVHSL AKWKRWMLWK LRDDGVSGIW CDMRGIRKCE
DADVICTSRM HSYQVEQFDW EKVIPSEKRN IEFLKETVRE IYRGLKAAKE RVDAEYPGMF
LRNKLADEVR FVQSQELEEL FPELNAQERE NAIAREAGSV FIIGIGHPLK SGKEHGQRSA
DYDDWDLNGD LIVWNEVIGC GMEVSSMGIR VDHTSLRRQL EAKNESRKAE YEFHRGVLEG
VIPPTIGGGI GKSRVVMFLL EARHIGEIQA SVWPKKVHEE CADEGIHLL
//
