GenomeNet

Database: UniProt
Entry: B7Z0Z2_DROME
LinkDB: B7Z0Z2_DROME
Original site: B7Z0Z2_DROME 
ID   B7Z0Z2_DROME            Unreviewed;      2114 AA.
AC   B7Z0Z2;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   20-DEC-2017, entry version 79.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=para {ECO:0000313|EMBL:ACL82937.1,
GN   ECO:0000313|FlyBase:FBgn0285944};
GN   Synonyms=bas {ECO:0000313|EMBL:ACL82937.1}, bss
GN   {ECO:0000313|EMBL:ACL82937.1}, Dmel\CG9907
GN   {ECO:0000313|EMBL:ACL82937.1}, DmNa[[V]]
GN   {ECO:0000313|EMBL:ACL82937.1}, DmNa[[v]]
GN   {ECO:0000313|EMBL:ACL82937.1}, DmNa[[v]]1
GN   {ECO:0000313|EMBL:ACL82937.1}, DmNav1 {ECO:0000313|EMBL:ACL82937.1},
GN   l(1)14Da {ECO:0000313|EMBL:ACL82937.1}, l(1)ESHS48
GN   {ECO:0000313|EMBL:ACL82937.1}, lincRNA.S9469
GN   {ECO:0000313|EMBL:ACL82937.1}, Ocd {ECO:0000313|EMBL:ACL82937.1}, olfD
GN   {ECO:0000313|EMBL:ACL82937.1}, par {ECO:0000313|EMBL:ACL82937.1}, sbl
GN   {ECO:0000313|EMBL:ACL82937.1}, sbl-1 {ECO:0000313|EMBL:ACL82937.1};
GN   ORFNames=CG9907 {ECO:0000313|EMBL:ACL82937.1,
GN   ECO:0000313|FlyBase:FBgn0285944}, Dmel_CG9907
GN   {ECO:0000313|EMBL:ACL82937.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:ACL82937.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:ACL82937.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:ACL82937.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:ACL82937.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:ACL82937.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:ACL82937.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:ACL82937.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:ACL82937.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:ACL82937.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AE014298; ACL82937.1; -; Genomic_DNA.
DR   RefSeq; NP_001138205.1; NM_001144733.2.
DR   UniGene; Dm.22809; -.
DR   ProteinModelPortal; B7Z0Z2; -.
DR   PaxDb; B7Z0Z2; -.
DR   PRIDE; B7Z0Z2; -.
DR   EnsemblMetazoa; FBtr0290121; FBpp0288560; FBgn0264255.
DR   GeneID; 32619; -.
DR   CTD; 32619; -.
DR   FlyBase; FBgn0285944; para.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OrthoDB; EOG091G00FK; -.
DR   ChiTaRS; Prm; fly.
DR   GenomeRNAi; 32619; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0264255; -.
DR   ExpressionAtlas; B7Z0Z2; differential.
DR   Genevisible; B7Z0Z2; DM.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    134    161       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    205    227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    239    257       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    263    285       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    395    417       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    792    815       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    836    853       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    865    889       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    920    942       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1000   1021       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1324   1346       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1352   1372       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1413   1436       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1517   1543       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1606   1624       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1636   1655       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1667   1686       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1730   1753       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1816   1839       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1860   1895       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED       24     44       {ECO:0000256|SAM:Coils}.
FT   COILED      421    471       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2114 AA;  237417 MW;  87FF0B77ED42A45C CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV IRYDDEDEDE
     GPQPDPTLEQ GVPIPVRLQG SFPPELASTP LEDIDPYYSN VLTFVVVSKG KDIFRFSASK
     AMWMLDPFNP IRRVAIYILV HPLFSLFIIT TILVNCILMI MPTTPTVEST EVIFTGIYTF
     ESAVKVMARG FILCPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT FRVLRALKTV
     AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC IKKFPLDGSW
     GNLTDENWDY HNRNSSNWYS EDEGISFPLC GNISGAGQCD DDYVCLQGFG PNPNYGYTSF
     DSFGWAFLSA FRLMTQDFWE DLYQLVLRAA GPWHMLFFIV IIFLGSFYLV NLILAIVAMS
     YDELQKKAEE EEAAEEEAIR EAEEAAAAKA AKLEERANAQ AQAAADAAAA EEAALHPEMA
     KSPTYSCISY ELFVGGEKGN DDNNKEKMSI RSVEVESESV SVIQRQPAPT TAHQATKVRK
     VSTTSLSLPG SPFNIRRGSR SSHKYTIRNG RGRFGIPGSD RKPLVLSTYQ DAQQHLPYAD
     DSNAVTPMSE ENGAIIVPVY YGNLGSRHSS YTSHQSRISY TSHGDLLGGM AVMGVSTMTK
     ESKLRNRNTR NQSVGATNGG TTCLDTNHKL DHRDYEIGLE CTDEAGKIKH HDNPFIEPVQ
     TQTVVDMKDV MVLNDIIEQA AGRHSRASDR GEDDDEDGPT FKDKALEVIL KGIDVFCVWD
     CCWVWLKFQE WVSLIVFDPF VELFITLCIV VNTMFMAMDH HDMNKEMERV LKSGNYFFTA
     TFAIEATMKL MAMSPKYYFQ EGWNIFDFII VALSLLELGL EGVQGLSVLR SFRLLRVFKL
     AKSWPTLNLL ISIMGRTVGA LGNLTFVLCI IIFIFAVMGM QLFGKNYTDH KDRFPDGDLP
     RWNFTDFMHS FMIVFRVLCG EWIESMWDCM YVGDVSCIPF FLATVVIGNL VVLNLFLALL
     LSNFGSSSLS APTADNDTNK IAEAFNRIGR FKSWVKRNIA DCFKLIRNKL TNQISDQPSE
     HGDNELELGH DEILADGLIK KGIKEQTQLE VAIGDGMEFT IHGDMKNNKP KKSKYLNNAT
     MIGNSINHQD NRLEHELNHR GLSLQDDDTA SINSYGSHKN RPFKDESHKG SAETMEGEEK
     RDASKEDLGL DEELDEEGEC EEGPLDGDII IHAHDEDILD EYPADCCPDS YYKKFPILAG
     DDDSPFWQGW GNLRLKTFQL IENKYFETAV ITMILMSSLA LALEDVHLPQ RPILQDILYY
     MDRIFTVIFF LEMLIKWLAL GFKVYFTNAW CWLDFVIVML SLINLAAVWS GADDVPAFRS
     MRTLRALRPL RAVSRWEGMK VVVNALVQAI PSIFNVLLVC LIFWLIFAIM GVQLFAGKYF
     KCEDMNGTKL SHEIIPNRNA CESENYTWVN SAMNFDHVGN AYLCLFQVAT FKGWIQIMND
     AIDSREVDKQ PIRETNIYMY LYFVFFIIFG SFFTLNLFIG VIIDNFNEQK KKAGGSLEMF
     MTEDQKKYYN AMKKMGSKKP LKAIPRPRWR PQAIVFEIVT DKKFDIIIML FIGLNMFTMT
     LDRYDASDTY NAVLDYLNAI FVVIFSSECL LKIFALRYHY FIEPWNLFDV VVVILSILGL
     VLSDIIEKYF VSPTLLRVVR VAKVGRVLRL VKGAKGIRTL LFALAMSLPA LFNICLLLFL
     VMFIFAIFGM SFFMHVKEKS GINDVYNFKT FGQSMILLFQ MSTSAGWDGV LDAIINEEAC
     DPPDNDKGYP GNCGSATVGI TFLLSYLVIS FLIVINMYIA VILENYSQAT EDVQEGLTDD
     DYDMYYEIWQ QFDPEGTQYI RYDQLSEFLD VLEPPLQIHK PNKYKIISMD IPICRGDLMY
     CVDILDALTK DFFARKGNPI EETGEIGEIA ARPDTEGYEP VSSTLWRQRE EYCARLIQHA
     WRKHKARGEG GGSFEPDTDH GDGGDPDAGD PAPDEATDGD APAGGDGSVN GTAEGAADAD
     ESNVNSPGED AAAAAAAAAA AAAAGTTTAG SPGAGSAGRQ TAVLVESDGF VTKNGHKVVI
     HSRSPSITSR TADV
//
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