ID B7Z257_HUMAN Unreviewed; 451 AA.
AC B7Z257;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 105.
DE SubName: Full=Regulator of G protein signaling 7 {ECO:0000313|Ensembl:ENSP00000509835.1};
DE SubName: Full=cDNA FLJ61685, highly similar to Regulator of G-protein signaling 7 {ECO:0000313|EMBL:BAH11743.1};
GN Name=RGS7 {ECO:0000313|Ensembl:ENSP00000509835.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH11743.1};
RN [1] {ECO:0000313|Ensembl:ENSP00000509835.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H.,
RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C.,
RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R.,
RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.,
RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.,
RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R.,
RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D.,
RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A.,
RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S.,
RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A.,
RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S.,
RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A.,
RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L.,
RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z.,
RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C.,
RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M.,
RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2] {ECO:0000313|EMBL:BAH11743.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Amygdala {ECO:0000313|EMBL:BAH11743.1};
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSP00000509835.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AL359764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL365184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL512307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL592076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL596082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK294354; BAH11743.1; -; mRNA.
DR RefSeq; XP_016857494.1; XM_017002005.1.
DR RefSeq; XP_016857495.1; XM_017002006.1.
DR RefSeq; XP_016857496.1; XM_017002007.1.
DR ProteomicsDB; 6409; -.
DR DNASU; 6000; -.
DR Ensembl; ENST00000685936.1; ENSP00000510372.1; ENSG00000182901.18.
DR Ensembl; ENST00000688703.1; ENSP00000510116.1; ENSG00000182901.18.
DR Ensembl; ENST00000690614.1; ENSP00000509835.1; ENSG00000182901.18.
DR HGNC; HGNC:10003; RGS7.
DR GeneTree; ENSGT00940000156661; -.
DR OrthoDB; 22856at2759; -.
DR BioGRID-ORCS; 6000; 23 hits in 1160 CRISPR screens.
DR GenomeRNAi; 6000; -.
DR Proteomes; UP000005640; Chromosome 1.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd00068; GGL; 1.
DR CDD; cd08738; RGS_RGS7; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF7; REGULATOR OF G-PROTEIN SIGNALING 7; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 1.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:B7Z257,
KW ECO:0007829|PeptideAtlas:B7Z257};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 11..86
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 307..422
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 209..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 451 AA; 52785 MW; D3633E6E086B0785 CRC64;
MEDVIARMQD EKNGIPIRTV KSFLSKIPSV FSGSDIVQWL IKNLTIEDPV EALHLGTLMA
AHGYFFPISD HVLTLKDDGT FYRFQTPYFW PSNCWEPENT DYAVYLCKRT MQNKARLELA
DYEAESLARL QRAFARKWEF IFMQAEAQAK VDKKRDKIER KILDSQERAF WDVHRPVPGC
VNTTEVDIKK SSRMRNPHKT RKSVYGLQND IRSHSPTHTP TPETKPPTED ELQQQIKYWQ
IQLDRHRLKM SKVADSLLSY TEQYLEYDPF LLPPDPSNPW LSDDTTFWEL EASKEPSQQR
VKRWGFGMDE ALKDPVGREQ FLKFLESEFS SENLRFWLAV EDLKKRPIKE VPSRVQEIWQ
EFLAPGAPSA INLDSKSYDK TTQNVKEPGR YTFEDAQEHI YKLMKSDSYP RFIRSSAYQE
LLQAKKKGRN IPIFPCHKNC TPTLRASTNL L
//