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Database: UniProt
Entry: B7Z257_HUMAN
LinkDB: B7Z257_HUMAN
Original site: B7Z257_HUMAN 
ID   B7Z257_HUMAN            Unreviewed;       451 AA.
AC   B7Z257;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   24-JAN-2024, entry version 105.
DE   SubName: Full=Regulator of G protein signaling 7 {ECO:0000313|Ensembl:ENSP00000509835.1};
DE   SubName: Full=cDNA FLJ61685, highly similar to Regulator of G-protein signaling 7 {ECO:0000313|EMBL:BAH11743.1};
GN   Name=RGS7 {ECO:0000313|Ensembl:ENSP00000509835.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH11743.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000509835.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H.,
RA   Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C.,
RA   Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R.,
RA   Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.,
RA   Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.,
RA   Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R.,
RA   Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D.,
RA   Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A.,
RA   Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S.,
RA   Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A.,
RA   Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S.,
RA   Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A.,
RA   Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L.,
RA   Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z.,
RA   Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C.,
RA   Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M.,
RA   Langford C.F., Pandian R.D., Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|EMBL:BAH11743.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Amygdala {ECO:0000313|EMBL:BAH11743.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000509835.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   EMBL; AL359764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL365184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL512307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL590682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL592076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL596082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK294354; BAH11743.1; -; mRNA.
DR   RefSeq; XP_016857494.1; XM_017002005.1.
DR   RefSeq; XP_016857495.1; XM_017002006.1.
DR   RefSeq; XP_016857496.1; XM_017002007.1.
DR   ProteomicsDB; 6409; -.
DR   DNASU; 6000; -.
DR   Ensembl; ENST00000685936.1; ENSP00000510372.1; ENSG00000182901.18.
DR   Ensembl; ENST00000688703.1; ENSP00000510116.1; ENSG00000182901.18.
DR   Ensembl; ENST00000690614.1; ENSP00000509835.1; ENSG00000182901.18.
DR   HGNC; HGNC:10003; RGS7.
DR   GeneTree; ENSGT00940000156661; -.
DR   OrthoDB; 22856at2759; -.
DR   BioGRID-ORCS; 6000; 23 hits in 1160 CRISPR screens.
DR   GenomeRNAi; 6000; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   CDD; cd04450; DEP_RGS7-like; 1.
DR   CDD; cd00068; GGL; 1.
DR   CDD; cd08738; RGS_RGS7; 1.
DR   Gene3D; 1.10.1240.60; -; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR015898; G-protein_gamma-like_dom.
DR   InterPro; IPR036284; GGL_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR047016; RGS6/7/9/11.
DR   InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR   InterPro; IPR040759; RGS_DHEX.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45746; LP21163P; 1.
DR   PANTHER; PTHR45746:SF7; REGULATOR OF G-PROTEIN SIGNALING 7; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00631; G-gamma; 1.
DR   Pfam; PF00615; RGS; 1.
DR   Pfam; PF18148; RGS_DHEX; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM01224; G_gamma; 1.
DR   SMART; SM00224; GGL; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|MaxQB:B7Z257,
KW   ECO:0007829|PeptideAtlas:B7Z257};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT   DOMAIN          11..86
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          307..422
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   REGION          209..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   451 AA;  52785 MW;  D3633E6E086B0785 CRC64;
     MEDVIARMQD EKNGIPIRTV KSFLSKIPSV FSGSDIVQWL IKNLTIEDPV EALHLGTLMA
     AHGYFFPISD HVLTLKDDGT FYRFQTPYFW PSNCWEPENT DYAVYLCKRT MQNKARLELA
     DYEAESLARL QRAFARKWEF IFMQAEAQAK VDKKRDKIER KILDSQERAF WDVHRPVPGC
     VNTTEVDIKK SSRMRNPHKT RKSVYGLQND IRSHSPTHTP TPETKPPTED ELQQQIKYWQ
     IQLDRHRLKM SKVADSLLSY TEQYLEYDPF LLPPDPSNPW LSDDTTFWEL EASKEPSQQR
     VKRWGFGMDE ALKDPVGREQ FLKFLESEFS SENLRFWLAV EDLKKRPIKE VPSRVQEIWQ
     EFLAPGAPSA INLDSKSYDK TTQNVKEPGR YTFEDAQEHI YKLMKSDSYP RFIRSSAYQE
     LLQAKKKGRN IPIFPCHKNC TPTLRASTNL L
//
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