GenomeNet

Database: UniProt
Entry: B7Z2A9_HUMAN
LinkDB: B7Z2A9_HUMAN
Original site: B7Z2A9_HUMAN 
ID   B7Z2A9_HUMAN            Unreviewed;       794 AA.
AC   B7Z2A9;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-SEP-2017, entry version 53.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A1 {ECO:0000313|Ensembl:ENSP00000466878};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH11795.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000466878, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|EMBL:BAH11795.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Amygdala {ECO:0000313|EMBL:BAH11795.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000466878}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [5] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; AC067852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC107993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK294512; BAH11795.1; -; mRNA.
DR   UniGene; Hs.463074; -.
DR   MaxQB; B7Z2A9; -.
DR   Ensembl; ENST00000585525; ENSP00000466878; ENSG00000033627.
DR   UCSC; uc010wgj.3; human.
DR   EuPathDB; HostDB:ENSG00000033627.14; -.
DR   HGNC; HGNC:865; ATP6V0A1.
DR   OpenTargets; ENSG00000033627; -.
DR   GeneTree; ENSGT00390000004941; -.
DR   HOVERGEN; HBG014606; -.
DR   ChiTaRS; ATP6V0A1; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000033627; -.
DR   ExpressionAtlas; B7Z2A9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Proteomics identification {ECO:0000213|EPD:B7Z2A9,
KW   ECO:0000213|MaxQB:B7Z2A9, ECO:0000213|PeptideAtlas:B7Z2A9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    358    382       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    402    421       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    498    519       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    525    549       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    590    614       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    698    721       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    727    750       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   794 AA;  91157 MW;  82CF960409AFC2A7 CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEMA DPDLLEESSS LLEPSEMGRG
     TPLRLGFVAG VINRERIPTF ERMLWRVCRG NVFLRQAEIE NPLEDPVTGD YVHKSVFIIF
     FQGDQLKNRV KKICEGFRAS LYPCPETPQE RKEMASGVNT RIDDLQMVLN QTEDHRQRVL
     QAAAKNIRVW FIKVRKMKAI YHTLNLCNID VTQKCLIAEV WCPVTDLDSI QFALRRGTEH
     SGSTVPSILN RMQTNQTPPT YNKTNKFTYG FQNIVDAYGI GTYREINPAP YTIITFPFLF
     AVMFGDFGHG ILMTLFAVWM VLRESRILSQ KNENEMFSTV FSGRYIILLM GVFSMYTGLI
     YNDCFSKSLN IFGSSWSVRP MFTYNWTEET LRGNPVLQLN PALPGVFGGP YPFGIDPIWN
     IATNKLTFLN SFKMKMSVIL GIIHMLFGVS LSLFNHIYFK KPLNIYFGFI PEIIFMTSLF
     GYLVILIFYK WTAYDAHTSE NAPSLLIHFI NMFLFSYPES GYSMLYSGQK GIQCFLVVVA
     LLCVPWMLLF KPLVLRRQYL RRKHLGTLNF GGIRVGNGPT EEDAEIIQHD QLSTHSEDAD
     EPSEDEVFDF GDTMVHQAIH TIEYCLGCIS NTASYLRLWA LSLAHAQLSE VLWTMVIHIG
     LSVKSLAGGL VLFFFFTAFA TLTVAILLIM EGLSAFLHAL RLHWVEFQNK FYSGTGFKFL
     PFSFEHIREG KFEE
//
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