ID   B7Z2F6_HUMAN            Unreviewed;       759 AA.
AC   B7Z2F6;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   22-FEB-2023, entry version 89.
DE   SubName: Full=cDNA FLJ54744, highly similar to Scaffold attachment factor B {ECO:0000313|EMBL:BAH11842.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH11842.1};
RN   [1] {ECO:0000313|EMBL:BAH11842.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAH11842.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AK294671; BAH11842.1; -; mRNA.
DR   RefSeq; NP_001307500.1; NM_001320571.1.
DR   AlphaFoldDB; B7Z2F6; -.
DR   MaxQB; B7Z2F6; -.
DR   PeptideAtlas; B7Z2F6; -.
DR   ProteomicsDB; 6439; -.
DR   DNASU; 6294; -.
DR   GeneID; 6294; -.
DR   CTD; 6294; -.
DR   OrthoDB; 5405075at2759; -.
DR   BioGRID-ORCS; 6294; 101 hits in 1171 CRISPR screens.
DR   GenomeRNAi; 6294; -.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   CDD; cd12679; RRM_SAFB1_SAFB2; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034781; SAFB1_2_RBD.
DR   PANTHER; PTHR15683; SCAFFOLD ATTACHMENT FACTOR B-RELATED; 1.
DR   PANTHER; PTHR15683:SF6; SCAFFOLD ATTACHMENT FACTOR B1; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT   DOMAIN          249..327
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   REGION          67..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..481
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          513..553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          591..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..81
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..117
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..155
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..203
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..246
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..391
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        427..481
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        591..644
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        657..697
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   759 AA;  86100 MW;  E57439CBF54028F2 CRC64;
     MKVVILTKLK LPPRETRKHQ RGLAKIEDKE TINNLDTSSS DFTILQEIEE PSLEPENEKI
     LDILGETCKS EPVKEESSEL EQPFAQDTSS VGPDRKLAEE EDLFDSAHPE EGDLDLASES
     TAHAQSSKAD SLLAVVKREP AEQPGDGERT DCEPVGLEPA VEQSSAASEL AEASSEELAE
     APTEAPSPEA RDSKEDGRKF DFDACNEVPP APKESSTSEG ADQKMSSPED DSDTKRLSKE
     EKGRSSCGRN FWVSGLSSTT RATDLKNLFS KYGKVVGAKV VTNARSPGAR CYGFVTMSTA
     EEATKCINHL HKTELHGKMI SVEKAKNEPV GKKTSDKRDS DGKKEKSSNS DRSTNLKRDD
     KCDRKDDAKK GDDGSGEKSK DQDDQKPGPS ERSRATKSGS RGTERTVVMD KSKGVPVISV
     KTSGSKERAS KSQDRKSASR EKRSVVSFDK VKEPRKSRDS ESHRVRERSE REQRMQAQWE
     REERERLEIA RERLAFQRQR LERERMERER LERERMHVEH ERRREQERIH REREELRRQQ
     ELRYEQERRP AVRRPYDLDR RDDAYWPEAK RAALDERYHS DFNRQDRFHD FDHRDRGRYP
     DHSVDRREGS RSMMGEREGQ HYPERHGGPE RHGRDSRDGW GGYGSDKRMS EGRGLPPPPR
     GRRDWGDHGR REDDRSWQGT ADGGMMDRDH KRWQGGERSM SGHSGPGHMM NRGGMSGRGS
     FAPGGASRGH PIPHGGMQGG FGGQSRGSRP SDARFTRRY
//