ID B7Z405_HUMAN Unreviewed; 731 AA.
AC B7Z405;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 08-NOV-2023, entry version 88.
DE SubName: Full=cDNA FLJ50019, highly similar to Ras GTPase-activating protein 4 {ECO:0000313|EMBL:BAH12391.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH12391.1};
RN [1] {ECO:0000313|EMBL:BAH12391.1}
RP NUCLEOTIDE SEQUENCE.
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AK296589; BAH12391.1; -; mRNA.
DR AlphaFoldDB; B7Z405; -.
DR PeptideAtlas; B7Z405; -.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR CDD; cd04025; C2B_RasA1_RasA4; 1.
DR CDD; cd13372; PH_CAPRI; 1.
DR CDD; cd05395; RasGAP_RASA4; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037777; RASA4_PH.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF4; RAS GTPASE-ACTIVATING PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 2: Evidence at transcript level;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 44..160
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 230..440
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 494..601
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 709..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 731 AA; 82243 MW; A1D48C201C617C39 CRC64;
MDEDALSRDD VIGKVCLTRD TIASHPKGFS GWAHLTEVDP DEEVQGEIHL RLEVWPGARA
CRLRCSVLEA RDLAPKDRNG TSDPFVRVRY KGRTRETSIV KKSCYPRWNE TFEFELQEGA
MEALCVEAWD WDLVSRNDFL GKVVIDVQRL RVVQQEEGWF RLQPDQSKSR RHDEGNLGSL
QLEVRLRDET VLPSSYYQPL VHLLCHEVKL GMQGPGQLIP LIEETTSTEC RQDVATNLLK
LFLGQGLAKD FLDLLFQLEL SRTSETNTLF RSNSLASKSV ESFLKVAGMQ YLHGVLGPII
NKVFEEKKYV ELDPSKVEVK DVGCSGLHRP QTEAEVLEQS AQTLRAHLGA LLSALSRSVR
ACPAVVRATF RQLFRRVRER FPGAQHENVP FIAVTSFLCL RFFSPAIMSP KLFHLRERHA
DARTSRTLLL LAKAVQNVGN MDTPASRAKE AWMEPPQPTV RQGVAQLKDF ITKLVDIEEK
DELDLRRTLS LQAPPVKEGP LFIHRTKGKG PLMSSSFKKL YFSLTTEALS FAKTPSSKKS
ALIKLANIRA AEKVEEKSFG GSHVMQVIYT DDAGRPQTAY LQCKCVNELN QWLSALRKVS
INNTGLLGSY HPGVFRGDKW SCCHQKEKTG QGCDKTRSRV TLQEWNDPLD HDLEAQLIYR
HLLGVEAMLW ERHRELSGGA EAGTVPTSPG KVPEDSLARL LRVLQDLREA HSSSPAGSPP
SEPNCLLELQ T
//
