ID B7Z826_HUMAN Unreviewed; 1382 AA.
AC B7Z826;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=cDNA FLJ54394, highly similar to Crumbs homolog 1 {ECO:0000313|EMBL:BAH13812.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH13812.1};
RN [1] {ECO:0000313|EMBL:BAH13812.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:BAH13812.1};
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AK302826; BAH13812.1; -; mRNA.
DR RefSeq; NP_001244894.1; NM_001257965.1.
DR PeptideAtlas; B7Z826; -.
DR DNASU; 23418; -.
DR GeneID; 23418; -.
DR CTD; 23418; -.
DR OrthoDB; 2877476at2759; -.
DR BioGRID-ORCS; 23418; 6 hits in 1135 CRISPR screens.
DR GenomeRNAi; 23418; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 15.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 17.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00008; EGF; 13.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF02210; Laminin_G_2; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01983; NOTCH.
DR SMART; SM00181; EGF; 17.
DR SMART; SM00179; EGF_CA; 16.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 11.
DR PROSITE; PS50026; EGF_3; 17.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1320..1344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..39
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 41..77
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 79..115
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 117..153
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 155..191
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 193..230
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 232..268
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 270..326
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 328..365
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 372..412
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 416..601
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 603..639
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 645..816
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 864..899
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 926..1113
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1115..1151
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1153..1188
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1190..1226
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1231..1271
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1273..1309
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 10..27
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 29..38
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 67..76
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 105..114
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 143..152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 181..190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 258..267
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 316..325
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 402..411
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 629..638
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 889..898
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1141..1150
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1157..1167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1178..1187
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1216..1225
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1261..1270
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1299..1308
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1382 AA; 151197 MW; EFEFA1B927E7AE6E CRC64;
MKDPCFSNPC QGSATCVNTP GERSFLCKCP PGYSGTICET TIGSCGKNSC QHGGICHQDP
IYPVCICPAG YAGRFCEIDH DECASSPCQN GAVCQDGIDG YSCFCVPGYQ GRHCDLEVDE
CASDPCKNEA TCLNEIGRYT CICPHNYSGV NCELEIDECW SQPCLNGATC QDALGAYFCD
CAPGFLGDHC ELNTDECASQ PCLHGGLCVD GENRYSCNCT GSGFTGTHCE TLMPLCWSKP
CHNNATCEDS VDNYTCHCWP GYTGAQCEID LNECNSNPCQ SNGECVELSS EKQYGRITGL
PSSFSYHEAS GYVCICQPGF TGIHCEEDVN ECSSNPCQNG GTCENLPGNY TCHCPFDNLS
RTFCGGRDCS DILLGCTHQQ CLNNGTCIPH FQDGQHGFSC LCPSGYTGSL CEIATTLSFE
GDGFLWVKSG SVTTKGSVCN IALRLQTVQP MALLLFRSNR DVFVKLELLS GYIHLSIQVN
NQSKVLLFIS HNTSDGEWHF VEVIFAEAVT LTLIDDSCKE KCIAKAPTPL ESDQSICAFQ
NSFLGGLPVG MTSNGVALLN FYNMPSTPSF VGCLQDIKID WNHITLENIS SGSSLNVKAG
CVRKDWCESQ LCQSRGRCIN LWLSYQCDCH RPYEGPNCLR EYVAGRFGQD DSTGYVIFTL
DESYGDTISL SMFVRTLQPS GLLLALENST YQYIRVWLER GRLAMLTPNS PKLVVKFVLN
DGNVHLISLK IKPYKIELYQ SSQNLGFISA STWKIEKGDV IYIGGLPDKQ ETELNGGFFK
GCIQDVRLNN QNLEFFPNPT NNASLNPVLV NVTQGCAGDN SCKRQTNVGR AFTELGSRGP
KYQVSLFRFC VGSWATGNTF FLSSIKPGSN PCHNGGVCHS RWDDFSCSCP ALTSGKACEE
VQWCGFSPCP HGAQCQPVLQ GFECIANAVF NGQSGQILFR SNGNITRELT NITFGFRTRD
ANVIILHAEK EPEFLNISIQ DSRLFFQLQS GNSFYMLSLT SLQSVNDGTW HEVTLSMTDP
LSQTSRWQME VDNETPFVTS TIATGSLNFL KDNTDIYVGD RAIDNIKGLQ GCLSTIEIGG
IYLSYFENVH GFINKPQEEQ FLKISTNSVV TGCLQLNVCN SNPCLHGGNC EDIYSSYHCS
CPLGWSGKHC ELNIDECFSN PCIHGNCSDR VAAYHCTCEP GYTGVDCEVD IDNCQSHQCA
NGATCISHTN GYSCLCFGNF TGKFCRQSRL PSTVCGNEKT NLTCYNGGNC TEFQTELKCM
CRPGFTGEWC EKDIDECASD PCVNGGLCQD LLNKFQCLCD VAFAGERCEV DLADDLISDI
FTTIGSVTVA LLLILLLAIV ASVVTSNKRA TQGTYSPSRQ EKEGSRVEMW NLMPPPAMER
LI
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