ID B7Z8J2_HUMAN Unreviewed; 264 AA.
AC B7Z8J2;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 13-SEP-2023, entry version 54.
DE SubName: Full=cDNA FLJ50433, highly similar to GRB2-related adapter protein 2 {ECO:0000313|EMBL:BAH13978.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH13978.1};
RN [1] {ECO:0000313|EMBL:BAH13978.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thymus {ECO:0000313|EMBL:BAH13978.1};
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AK303512; BAH13978.1; -; mRNA.
DR AlphaFoldDB; B7Z8J2; -.
DR PeptideAtlas; B7Z8J2; -.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR CDD; cd11950; SH3_GRAP2_C; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035646; GRAP2_C_SH3.
DR InterPro; IPR043539; Grb2-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46037:SF3; GRB2-RELATED ADAPTER PROTEIN 2; 1.
DR PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 205..264
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 78..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 264 AA; 30524 MW; 35881D35C0C2AB2E CRC64;
MLEFVSLLAR KDSNNSVSKP RHKLNPFSSR RHEDDVQHFK VMRDNKGNYF LWTEKFPSLN
KLVDYYRTNS ISRQKQIFLR DRTREDQGHR GNSLDRRSQG GPHLSGAVGE EIRPSMNRKL
SDHPPTLPLQ QHQHQPQPPQ YAPAPQQLQQ PPQQRYLQHH HFHQERRGGS LDINDGHCGT
GLGSEMNAAL MHRRHTDPVQ LQAAGRVRWA RALYDFEALE DDELGFHSGE VVEVLDSSNP
SWWTGRLHNK LGLFPANYVA PMTR
//
