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Database: UniProt
Entry: B7ZBV3_MOUSE
LinkDB: B7ZBV3_MOUSE
Original site: B7ZBV3_MOUSE 
ID   B7ZBV3_MOUSE            Unreviewed;       726 AA.
AC   B7ZBV3;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   22-NOV-2017, entry version 66.
DE   SubName: Full=Potassium voltage-gated channel subfamily KQT member 2 {ECO:0000313|Ensembl:ENSMUSP00000123488};
DE   Flags: Fragment;
GN   Name=Kcnq2 {ECO:0000313|Ensembl:ENSMUSP00000123488,
GN   ECO:0000313|MGI:MGI:1309503};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000123488, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000213|PubMed:16452087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
RA   Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,
RA   Burlingame A.L.;
RT   "Comprehensive identification of phosphorylation sites in postsynaptic
RT   density preparations.";
RL   Mol. Cell. Proteomics 5:914-922(2006).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000123488, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123488,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000123488}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123488};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000123488}.
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DR   EMBL; AL450341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; B7ZBV3; -.
DR   SMR; B7ZBV3; -.
DR   PaxDb; B7ZBV3; -.
DR   PeptideAtlas; B7ZBV3; -.
DR   Ensembl; ENSMUST00000129695; ENSMUSP00000123488; ENSMUSG00000016346.
DR   UCSC; uc008okw.2; mouse.
DR   MGI; MGI:1309503; Kcnq2.
DR   eggNOG; KOG1419; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00550000074513; -.
DR   HOGENOM; HOG000220839; -.
DR   HOVERGEN; HBG059014; -.
DR   Reactome; R-MMU-1296072; Voltage gated Potassium channels.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; ENSMUSG00000016346; -.
DR   ExpressionAtlas; B7ZBV3; baseline and differential.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   InterPro; IPR020969; Ankyrin-G_BS.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR003947; K_chnl_volt-dep_KCNQ2.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   PANTHER; PTHR11537:SF6; PTHR11537:SF6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   Pfam; PF11956; KCNQC3-Ank-G_bd; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Proteomics identification {ECO:0000213|MaxQB:B7ZBV3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM     12     33       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     54     73       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    120    138       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    179    204       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       10    204       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      322    507       KCNQ_channel. {ECO:0000259|Pfam:PF03520}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSMUSP00000123488}.
SQ   SEQUENCE   726 AA;  80275 MW;  191B2F3578FFCF1B CRC64;
     IKEYEKSSEG ALYILEIVTI VVFGVEYFVR IWAAGCCCRY RGWRGRLKFA RKPFCVIDIM
     VLIASIAVLA AGSQGNVFAT SALRSLRFLQ ILRMIRMDRR GGTWKLLGSV VYAHSKELVT
     AWYIGFLCLI LASFLVYLAE KGENDHFDTY ADALWWGLIT LTTIGYGDKY PQTWNGRLLA
     ATFTLIGVSF FALPAGILGS GFALKVQEQH RQKHFEKRRN PAAGLIQSAW RFYATNLSRT
     DLHSTWQYYE RTVTVPMYSS QTQTYGASRL IPPLNQLELL RNLKSKSGLT FRKEPQPEPS
     PSPRGMAAKG KGSPQAQTVR RSPSADQSLD DSPSKVPKSW SFGDRSRTRQ AFRIKGAASR
     QNSEEASLPG EDIVEDNKSC NCEFVTEDLT PGLKVSIRAV CVMRFLVSKR KFKESLRPYD
     VMDVIEQYSA GHLDMLSRIK SLQSRVDQIV GRGPTITDKD RTKGPAETEL PEDPSMMGRL
     GKVEKQVLSM EKKLDFLVSI YTQRMGIPPA ETEAYFGAKE PEPAPPYHSP EDSRDHADKH
     GCIIKIVRST SSTGQRNYAA PPAIPPAQCP PSTSWQQSHQ RHGTSPVGDH GSLVRIPPPP
     AHERSLSAYG GGNRASTEFL RLEGTPACRP SEAALRDSDT SISIPSVDHE ELERSFSGFS
     ISQSKENLDA LGSCYAAVAP CAKVRPYIAE GESDTDSDLC TPCGPPPRSA TGEGPFGDVA
     WAGPRK
//
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