ID B7ZKV2_HUMAN Unreviewed; 348 AA.
AC B7ZKV2;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=CD200R1 protein {ECO:0000313|EMBL:AAI43394.1};
GN Name=CD200R1 {ECO:0000313|EMBL:AAI43394.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAI43394.1};
RN [1] {ECO:0000313|EMBL:AAI43394.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung and heart {ECO:0000313|EMBL:AAI43394.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the CD200R family.
CC {ECO:0000256|ARBA:ARBA00008215}.
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DR EMBL; BC143393; AAI43394.1; -; mRNA.
DR AlphaFoldDB; B7ZKV2; -.
DR SMR; B7ZKV2; -.
DR PeptideAtlas; B7ZKV2; -.
DR ChiTaRS; CD200R1; human.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0150077; P:regulation of neuroinflammatory response; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR040012; CD200R.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR21462:SF2; CELL SURFACE GLYCOPROTEIN CD200 RECEPTOR 1; 1.
DR PANTHER; PTHR21462; CELL SURFACE GLYCOPROTEIN OX2 RECEPTOR PRECURSOR; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..348
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002866935"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 160..251
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 348 AA; 39055 MW; 32C0016F7746E1C1 CRC64;
MLCPWRTANL GLLLILTIFL VAEAEGAAQP NNSLMLQTSK ENHALASSSL CMDEKQITQN
YSKVLAEVNT SWPVKMATNA VLCCPPIALR NLIIITWEII LRGQPSCTKA YRKETNETKE
TNCTDERITW VSRPDQNSDL QIRPVAITHD GYYRCIMVTP DGNFHRGYHL QVLVTPEVTL
FQNRNRTAVC KAVAGKPAAQ ISWIPEGDCA TKQEYWSNGT VTVKSTCHWE VHNVSTVTCH
VSHLTGNKSL YIELLPVPGA KKSAKLYIPY IILTIIILTI VGFIWLLKVN GCRKYKLNKT
ESTPVVEEDE MQPYASYTEK NNPLYDTTNK VKASQALQSE VDTDLHTL
//
