ID   B7ZPA9_XENLA            Unreviewed;       405 AA.
AC   B7ZPA9;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   SubName: Full=Xnr-2 {ECO:0000313|EMBL:AAI69388.1};
GN   Name=nodal2.L {ECO:0000313|Xenbase:XB-GENE-865706};
GN   Synonyms=LOC397835 {ECO:0000313|EMBL:AAI69388.1}, nodal2
GN   {ECO:0000313|Xenbase:XB-GENE-865706};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI69388.1};
RN   [1] {ECO:0000313|EMBL:AAI69388.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000313|EMBL:AAI69388.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   EMBL; BC169388; AAI69388.1; -; mRNA.
DR   EMBL; BC169392; AAI69392.1; -; mRNA.
DR   RefSeq; NP_001081436.1; NM_001087967.1.
DR   STRING; 8355.B7ZPA9; -.
DR   PaxDb; 8355-B7ZPA9; -.
DR   GeneID; 397835; -.
DR   KEGG; xla:397835; -.
DR   AGR; Xenbase:XB-GENE-865706; -.
DR   CTD; 397835; -.
DR   Xenbase; XB-GENE-865706; nodal2.L.
DR   OMA; PSSWKVF; -.
DR   OrthoDB; 5393576at2759; -.
DR   Bgee; 397835; Expressed in gastrula and 1 other cell type or tissue.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd13759; TGF_beta_NODAL; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF159; NODAL HOMOLOG; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..405
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010959942"
FT   DOMAIN          279..405
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
SQ   SEQUENCE   405 AA;  46067 MW;  8D852DF28AF23C88 CRC64;
     MASLGVILFF VIASLIHGKP IHSERKAAKI PLEGSNLGYK KPNNIYGSRL SQGMRYPPSM
     MQLYQTLILG NDTDLSILEY PVLQESDAVL SLIAKSCVVV GNRWTLSFDM SSISSSNELK
     LAELRIRLPS FERSQDVTVE IYHTKEGQEN LFMGSFKTNP SVAMGSSWKI FNLTRMLQYY
     LHQGEPFTNV EYIEVKNMHE RAKPHVIKRG VRAEVEEGLQ RNKDNTPASS FPTERVVLVV
     FTRDKPTASH FGSPSLIHTV ESSKYVMSEN TVRVTDTRRP RRNQKTKNTI VMNTIPSRSV
     GKTLCRRVDM IVDFEKIEWG DRIVYPKRFN AYRCEGACPI PLNETFKPTN HAYIKSLVKL
     YDQEKVECSS CVPVKMSPLS MLLYEDGEVV LKHHEDMIVD ECGCN
//