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Database: UniProt
Entry: B7ZQI0_XENLA
LinkDB: B7ZQI0_XENLA
Original site: B7ZQI0_XENLA 
ID   B7ZQI0_XENLA            Unreviewed;       224 AA.
AC   B7ZQI0;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   RecName: Full=Glial cell line-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00015922, ECO:0000256|PIRNR:PIRNR016238};
GN   Name=gdnf {ECO:0000313|EMBL:AAI69813.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI69813.1};
RN   [1] {ECO:0000313|EMBL:AAI69813.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000313|EMBL:AAI69813.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Neurotrophic factor that enhances survival and morphological
CC       differentiation of dopaminergic neurons and increases their high-
CC       affinity dopamine uptake. {ECO:0000256|PIRNR:PIRNR016238}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|PIRNR:PIRNR016238}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|PIRNR:PIRNR016238}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC       {ECO:0000256|ARBA:ARBA00009832, ECO:0000256|PIRNR:PIRNR016238}.
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DR   EMBL; BC169813; AAI69813.1; -; mRNA.
DR   AlphaFoldDB; B7ZQI0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd19380; TGF_beta_GDNF; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR016649; GDNF.
DR   InterPro; IPR043401; GDNF_fam.
DR   InterPro; IPR047020; GDNF_TGF-b-like.
DR   InterPro; IPR001839; TGF-b_C.
DR   PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR   PANTHER; PTHR12173:SF1; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   PIRSF; PIRSF016238; GDNF; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR016238-1};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|PIRNR:PIRNR016238};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR016238};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..224
FT                   /note="Glial cell line-derived neurotrophic factor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002864202"
FT   DOMAIN          101..224
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   REGION          90..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        131..192
FT                   /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
FT   DISULFID        158..221
FT                   /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
FT   DISULFID        162..223
FT                   /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
FT   DISULFID        191
FT                   /note="Interchain"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
SQ   SEQUENCE   224 AA;  25462 MW;  D0DF9666F3BCDB0E CRC64;
     MKLWAILAVC ILLLSSVSSI PLPSNWLAGK KRSHLQEGED QVFGMDGAVP EDPTANMAPQ
     DQQTYTEIPD DYPDQFDDVL EFIQDTIKRL KRSSNKQPPS RRDRGRQSLA ANTQISSKKT
     VKDRKRKNKG CVLREIHLNV TDLGLGYETK EELKFRYCSG SCNNPETTYD QILKNLTIRK
     KLVNDKVKQA CCRPIAFDDD LSFLDDNLVY HTLKQHSAKK CGCI
//
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