ID B7ZQI0_XENLA Unreviewed; 224 AA.
AC B7ZQI0;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Glial cell line-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00015922, ECO:0000256|PIRNR:PIRNR016238};
GN Name=gdnf {ECO:0000313|EMBL:AAI69813.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI69813.1};
RN [1] {ECO:0000313|EMBL:AAI69813.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000313|EMBL:AAI69813.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Neurotrophic factor that enhances survival and morphological
CC differentiation of dopaminergic neurons and increases their high-
CC affinity dopamine uptake. {ECO:0000256|PIRNR:PIRNR016238}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|PIRNR:PIRNR016238}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR016238}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC {ECO:0000256|ARBA:ARBA00009832, ECO:0000256|PIRNR:PIRNR016238}.
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DR EMBL; BC169813; AAI69813.1; -; mRNA.
DR AlphaFoldDB; B7ZQI0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd19380; TGF_beta_GDNF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR016649; GDNF.
DR InterPro; IPR043401; GDNF_fam.
DR InterPro; IPR047020; GDNF_TGF-b-like.
DR InterPro; IPR001839; TGF-b_C.
DR PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR PANTHER; PTHR12173:SF1; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF016238; GDNF; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR016238-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR016238};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR016238};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..224
FT /note="Glial cell line-derived neurotrophic factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002864202"
FT DOMAIN 101..224
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 90..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 131..192
FT /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
FT DISULFID 158..221
FT /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
FT DISULFID 162..223
FT /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
FT DISULFID 191
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
SQ SEQUENCE 224 AA; 25462 MW; D0DF9666F3BCDB0E CRC64;
MKLWAILAVC ILLLSSVSSI PLPSNWLAGK KRSHLQEGED QVFGMDGAVP EDPTANMAPQ
DQQTYTEIPD DYPDQFDDVL EFIQDTIKRL KRSSNKQPPS RRDRGRQSLA ANTQISSKKT
VKDRKRKNKG CVLREIHLNV TDLGLGYETK EELKFRYCSG SCNNPETTYD QILKNLTIRK
KLVNDKVKQA CCRPIAFDDD LSFLDDNLVY HTLKQHSAKK CGCI
//