ID   B7ZS18_XENLA            Unreviewed;       453 AA.
AC   B7ZS18;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   SubName: Full=XLFli protein {ECO:0000313|EMBL:AAI70365.1};
GN   Name=fli1.S {ECO:0000313|Xenbase:XB-GENE-6253886};
GN   Synonyms=fli1 {ECO:0000313|Xenbase:XB-GENE-6253886}, Xlfli
GN   {ECO:0000313|EMBL:AAI70365.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI70365.1};
RN   [1] {ECO:0000313|EMBL:AAI70365.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocytes {ECO:0000313|EMBL:AAI70365.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU004019}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC       ECO:0000256|RuleBase:RU004019}.
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DR   EMBL; BC170365; AAI70365.1; -; mRNA.
DR   EMBL; BC170369; AAI70369.1; -; mRNA.
DR   RefSeq; NP_001084371.1; NM_001090902.1.
DR   GeneID; 399466; -.
DR   KEGG; xla:399466; -.
DR   AGR; Xenbase:XB-GENE-6253886; -.
DR   CTD; 399466; -.
DR   Xenbase; XB-GENE-6253886; fli1.S.
DR   OrthoDB; 2882052at2759; -.
DR   Bgee; 399466; Expressed in lung and 14 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd08541; SAM_PNT-FLI-1; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR035573; SAM_PNT-FLI-1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; ETS; 1.
DR   PANTHER; PTHR11849:SF161; FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW   Nucleus {ECO:0000256|RuleBase:RU004019};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          111..197
FT                   /note="PNT"
FT                   /evidence="ECO:0000259|PROSITE:PS51433"
FT   DOMAIN          282..362
FT                   /note="ETS"
FT                   /evidence="ECO:0000259|PROSITE:PS50061"
FT   REGION          201..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..273
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  51016 MW;  A6E6FCC60EC42DA4 CRC64;
     MDGTIKEALS VVSDDQSLFD SAYGASSHLS KADMTASANP DYGQPHKINP IPPQQDWINQ
     PMRVNIKREY EHMNGSRESP VDCSINKCSK LIGGSEGNAM TYTYMDEKNG PPPPNMTTNE
     RRVIVPADPA LWSQDHVRQW LEWAIKEYGL VEIDCSLFQN IDGKELCKMS KEDFLRSTSI
     YNTEVLLSHL NYLRDSSSSL GYNTQAHTDQ SSRLTAKEDP SYEAVRRSGW GNSMSSPVTK
     SPPMGGTQNV NKSGDQQRSQ PDPYQILGPT SSRLANPGSG QIQLWQFLLE LLSDSSNASC
     ITWEGTNGEF KMTDPDEVAR RWGERKSKPN MNYDKLSRAL RYYYDKSIMT KVHGKRYAYK
     FDFHGIAQAL QPHPTDTSMY KYPSEFSYMP SYHSHQQKVN FVPSHPSSMP VTSSGFFGAT
     SPYWNSPSAN IYPNPNVPRH PNTHVQSHLG GFY
//