ID B8A480_DANRE Unreviewed; 958 AA.
AC B8A480; A0A8M1N6C9;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=SH3 domain-containing 19 {ECO:0000313|Ensembl:ENSDARP00000111512};
DE SubName: Full=SH3 domain-containing protein 19 {ECO:0000313|RefSeq:NP_001018609.2};
GN Name=sh3d19 {ECO:0000313|Ensembl:ENSDARP00000111512,
GN ECO:0000313|RefSeq:NP_001018609.2,
GN ECO:0000313|ZFIN:ZDB-GENE-050522-481};
GN Synonyms=zgc:113078 {ECO:0000313|RefSeq:NP_001018609.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000111512};
RN [1] {ECO:0000313|RefSeq:NP_001018609.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001018609.2};
RX PubMed=12477932; DOI=10.1073/pnas.242603899;
RG Mammalian Gene Collection Program Team;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D.,
RA Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F.,
RA Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., Hopkins R.F., Jordan H.,
RA Moore T., Max S.I., Wang J., Hsieh F., Diatchenko L., Marusina K.,
RA Farmer A.A., Rubin G.M., Hong L., Stapleton M., Soares M.B., Bonaldo M.F.,
RA Casavant T.L., Scheetz T.E., Brownstein M.J., Usdin T.B., Toshiyuki S.,
RA Carninci P., Prange C., Raha S.S., Loquellano N.A., Peters G.J.,
RA Abramson R.D., Mullahy S.J., Bosak S.A., McEwan P.J., McKernan K.J.,
RA Malek J.A., Gunaratne P.H., Richards S., Worley K.C., Hale S., Garcia A.M.,
RA Gay L.J., Hulyk S.W., Villalon D.K., Muzny D.M., Sodergren E.J., Lu X.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., Rodriguez A.C.,
RA Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Krzywinski M.I.,
RA Skalska U., Smailus D.E., Schnerch A., Schein J.E., Jones S.J., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human and
RT mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000111512}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000111512};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000111512, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000111512};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_001018609.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001018609.2};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000157549}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000157549};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [6] {ECO:0000313|RefSeq:NP_001018609.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001018609.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX005068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR354380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001018609.2; NM_001020773.2.
DR STRING; 7955.ENSDARP00000111512; -.
DR PaxDb; 7955-ENSDARP00000110056; -.
DR Ensembl; ENSDART00000126950.4; ENSDARP00000111512.2; ENSDARG00000088202.4.
DR Ensembl; ENSDART00000190587.1; ENSDARP00000157549.1; ENSDARG00000114126.1.
DR GeneID; 553811; -.
DR KEGG; dre:553811; -.
DR AGR; ZFIN:ZDB-GENE-050522-481; -.
DR CTD; 152503; -.
DR ZFIN; ZDB-GENE-050522-481; sh3d19.
DR eggNOG; KOG4225; Eukaryota.
DR HOGENOM; CLU_015305_1_0_1; -.
DR OMA; FPRAFIE; -.
DR OrthoDB; 2920126at2759; -.
DR TreeFam; TF330850; -.
DR Proteomes; UP000000437; Alternate scaffold 1.
DR Proteomes; UP000000437; Chromosome 1.
DR Bgee; ENSDARG00000088202; Expressed in tail and 19 other cell types or tissues.
DR CDD; cd11816; SH3_Eve1_3; 1.
DR CDD; cd11817; SH3_Eve1_4; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR InterPro; IPR035835; Eve1_SH3_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR PANTHER; PTHR45929:SF2; SIGNAL TRANSDUCING ADAPTER MOLECULE 1; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 4.
DR SUPFAM; SSF50044; SH3-domain; 4.
DR PROSITE; PS50002; SH3; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 638..697
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 720..779
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 800..859
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 895..954
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..354
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..585
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 958 AA; 105799 MW; 6DAE892668A19AE1 CRC64;
MAEARCSDGS EDFSNVSVTR RRDSTDRSER SKPERLQISQ GPLSSIKAAI KRTSAKALPQ
PVCSRERRRP EITILSAEPF AATWYPVPSG RFSSTAFTTQ PVWSENALTS AQLPPSYEQV
IKEKTQEQVT TPSPSPRHSY TTTIATQTDS LEENVTSPDS CTSLQQNQQP AVLVKQPIKP
PRPTLPCKPK PLLQETTRSS TSTFISQPTV DQTPIQRPVP QPRTKFKPLS PSNQVTGQTL
IPLQDSCDTI SLVETFESHS GKYLKELVDV LSSEPQSELS NPVNNQGEQT NLTNENQIEN
MTFHHSDRNI RSRIQAFESQ AATENDAASV PFPRPRKIGA KPPILAPKPS IAPRPSVIKP
KEEPFSQFDS HLYEELDMEP TPAPRPQLFK KPSLDSREES DSQPFFKTAL TSRPSLVKHK
NVYSQDEEVV VKGPIPPLKP SKDLLNANNH NSTALLPDLT SAVNVLSNDY VDTSINHSPT
KPVRQGGFSY MGGNTQAVTR RPTVIRVPSK TDKNSEEAVE FPPPLPVQKA VGSTPTPAKA
FRQDPFNVSS DMSIPPRPSG GKVLPPRPPP AKTGPGRPPP PQTNNSQRRP SDSGFSQIAP
SKQQPSQWQQ QNRRASKKGP ALPPRPNPGH RLYNKYTLEV PHGIAEFDYN GSNTGELSFQ
KNEVLVLLEE LDSRTFECQA GNTKGTVQKS HMKIITPLTD LSSNSLPQKT SSFRGMGGNA
GSLQVEALYD FTPAGPGELA LKAGDVVSNV EQLDDDWYMG TCRNATGFFP INYVKVLSKP
NIYAPAFRNE WKNKPSPETV RGPRCVARFD FEGEQGDELS FFEDDVIQLK EYLGEEWARG
EVNGHVGIFP LNFVEVIEDL PSVPVQKSAP NKIALPGMAS SSTQSSYRAS EAESNGAEWA
VALYDFTAET EEDLPFQQGD RILVTAHVDD EWWSGRINGR EGFFPKAFVE SVADVRKW
//
