ID B8B7P8_ORYSI Unreviewed; 1166 AA.
AC B8B7P8;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=OsI_25098 {ECO:0000313|EMBL:EEC81606.1};
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946 {ECO:0000313|EMBL:EEC81606.1, ECO:0000313|Proteomes:UP000007015};
RN [1] {ECO:0000313|EMBL:EEC81606.1, ECO:0000313|Proteomes:UP000007015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11 {ECO:0000313|Proteomes:UP000007015};
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C., Chen H., Xu Z., Li H., Huang H., Zhang F., Xu H.,
RA Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W.,
RA Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L.,
RA Zheng W., Hao B., Liu S., Wang W., Yuan L., Cao M., McDermott J.,
RA Samudrala R., Wang J., Wong G.K., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; CM000132; EEC81606.1; -; Genomic_DNA.
DR AlphaFoldDB; B8B7P8; -.
DR STRING; 39946.B8B7P8; -.
DR EnsemblPlants; BGIOSGA025244-TA; BGIOSGA025244-PA; BGIOSGA025244.
DR Gramene; BGIOSGA025244-TA; BGIOSGA025244-PA; BGIOSGA025244.
DR HOGENOM; CLU_005943_0_0_1; -.
DR OMA; FSFMPEF; -.
DR Proteomes; UP000007015; Chromosome 7.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000007015};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1145..1164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..316
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 681..1090
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1166 AA; 130038 MW; 7B8E737E478AFE76 CRC64;
MAKVAVGQWV PHVEAFVDVS RPPAQHSASV DALSALVNKD KLTLFVLVSK MEMYLTTTDH
IVRSRGILLL GEILCRISFK QLDVNAISTL SDFFISRLSD WQALRGALVG CLALLHRKRT
VGSIIIADVK RLLETFLQNV QVQSLAAADR KLCFQILNYI LDHYPEAVKT MGDELLYGMC
EAIDEEKDPE CLKLSFNLVE AVMKLFPDPS GLAAQYASEV FEILSKYYPI YFTHGVGDDL
DATRDDLSKA LMHAFCSTPY FEPFAIPLLL DKLSSSLPLA KLDSLKYLDN CIRCYGADRM
GRHVITIWFK LKEVIFSLSI DQILSTSGAK DMEKNKNEIV SEALTCLKTA IIQMGPSDED
RLINLILLDE DIVSSIHSVA SEEASGLTSL QNPIQLHALG SVISILAESS AYFCTRVLQA
HFARLVDSLE ISAGRESQHL NNCSGPSSGA INYGALYLSV QMLSSCREVA LTYKEEFSPI
KSAKESWWLI LEKKLDSLIH ILQSLLTIDS QFVQSADRQE YVSCAVKGLI ILATFPEPRL
PLSASAYEDV LLTLTSVIMS KYENMHLWRL SLKALTTIGS SIVEFHASQK ENIYNKVVDK
ISSLDEPCRT SIPLNLRLEA CFEVGTSGSN CMLRIAKSLE EAVVNGRVKC SEYVVNLLEC
YCGRVLPWLF NFGGVNELAL NFAMRLWNEI RDLATSDRIG SQDLLSSLMM GMKLVIGICT
EEQQSLIVQK AYDTISSMLS LPVKSMTRHL LAVDEAVPLY SVRDTFLMCM LSSVIVGLRP
QTPVPDMLMM INLFTVFLLK GQIPAAHALA SIFNKNLHNS EFSHENKLDK VIDTILERCF
STISVRSNMK TSLSCAGRSD DANCSEILSG SIESKDDIIS GLAWLGKGLL MRGDEKVKDV
SLFLLKCLCS DQSLAGISSH QEEHGISDSS YASLATSAAD AFHVMMSDSE VCLNKKFHAR
IKPLYKQRFF SILMPIFLSK IKESTVMTTK LVLYRAFGHI ISNAPVPAVI TEAHRILLVM
VDSIAKLSQD VKDKDLVYSI LLVLSGMLMD EKGKECIVEN IHIIVSVLTQ LVSYPHMMVV
RETALQCLVA MSSLPHSKIY RMRPQILQAA IKALDDKKRR VRQEAVRCRQ TWYENLYHLW
SQGPGLMIFP FILLQAIICL KIVFLL
//
