ID B8C065_THAPS Unreviewed; 4410 AA.
AC B8C065;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Dynein heavy chain {ECO:0008006|Google:ProtNLM};
GN ORFNames=THAPSDRAFT_40445 {ECO:0000313|EMBL:EED93010.1};
OS Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=35128 {ECO:0000313|EMBL:EED93010.1, ECO:0000313|Proteomes:UP000001449};
RN [1] {ECO:0000313|EMBL:EED93010.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED93010.1};
RX PubMed=15459382; DOI=10.1126/science.1101156;
RA Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M., Brzezinski M.A.,
RA Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S., Detter J.C.,
RA Glavina T., Goodstein D., Hadi M.Z., Hellsten U., Hildebrand M.,
RA Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N., Lau W.W., Lane T.W.,
RA Larimer F.W., Lippmeier J.C., Lucas S., Medina M., Montsant A., Obornik M.,
RA Parker M.S., Palenik B., Pazour G.J., Richardson P.M., Rynearson T.A.,
RA Saito M.A., Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A.,
RA Wilkerson F.P., Rokhsar D.S.;
RT "The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and
RT metabolism.";
RL Science 306:79-86(2004).
RN [2] {ECO:0000313|EMBL:EED93010.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED93010.1};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
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DR EMBL; CM000641; EED93010.1; -; Genomic_DNA.
DR RefSeq; XP_002289473.1; XM_002289437.1.
DR STRING; 35128.B8C065; -.
DR PaxDb; 35128-Thaps40445; -.
DR EnsemblProtists; EED93010; EED93010; THAPSDRAFT_40445.
DR GeneID; 7443758; -.
DR KEGG; tps:THAPSDRAFT_40445; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_4_0_1; -.
DR InParanoid; B8C065; -.
DR OMA; ICEHMAY; -.
DR Proteomes; UP000001449; Chromosome 4.
DR GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0030286; C:dynein complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001449}.
FT DOMAIN 79..649
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1156..1566
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1705..1821
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1845..2052
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2218..2333
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2559..2646
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2702..2962
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2975..3314
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3345..3561
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3815..3930
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3961..4105
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4111..4407
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 2984..3060
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3193..3258
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3495..3529
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4410 AA; 500007 MW; 7CA51CB7434A155D CRC64;
MSSFDHLELV SKNVLLPVLS NQTNQFIWGE LTSREITDCF HSFLSSSAIL CGQVKAETRL
PTSSLDDENA SPETSNRISL LEGTIITWTK QIKNVLKQDP EAQLKLGFYP SPDVEIAFWK
NKADNLNSIF EQLQSPSIRR VLRALDQSKS TYCTTFARLC KEVYAARVEA NDNMKHLKAL
EKWVYKLNED DFSDLNTVFK PLMHILMLIW KHSTYYNTPT RLVILVREMC NSIIDQACRF
TSGEQIFSLI ENEEANVAVE KLLLVLRVCG SFKSIYSEYK SMVATTCPEN EWSVKNDVLF
ARLDSFIERC HDILALTKTI IQFSKLAKVE IGGTKGGTLT STIQQIKGDF QRAVNAVKNL
DFDIMDIQAT QFDGEYSDFK KSVKEIERRL GAVIGLALDD CETVYGRFQL VDTFDRHLLD
RPIIQEGVEV KQIKLIQSYG KDLKVIQEEF LQNRMNPPRD TVRNLPPISG SLTWCRGLVA
RVKIPMTKME ELDRNILDRE EAREVIKLQK AIMLSLLEFE ARKIAEWGRD VDATSCAKLE
LPLMRRSDES RQLTTNFDPA LVRLLREVKY FLLLGLSVPD SALKIFQSAD AFRAWTGNLD
LIVNMNNSVL AHLLPVEKPL VDPYLAKFDL AVKPGLETLN WKSNGVDEFI GDIMVQVKIV
HGILKTMKEN LSAVQDIVDK WDKPMIKRTT KPMEKEEFER SFKALKTTCF SEIKDAGKQI
HSLLKETNKV LRVSNTSTDW RCYVEFVNSV IVDGLSTAIM TSLNFLLDQI YPESIQKDDR
LPLFEIMLVL KESDGITFQP PLGRDENKRG MSDMIDSVIG SFFQIATLFK RLDTEGTYTR
EIHSDLDITS VLALLSDAIA TNDEKCLELK KTFDKYSYLW ETDLTSYFAD FCEDATIVTE
HGTKLLDLDK FDKAIQKCVD AQTEVAKAKS PVDIGWLRMD ITPAKREVSL FASKWIKLFT
THMRDSIINT LSDLHNFMET VTHGLTSDIE ESEEGHDTLM AVMSVIRDVR LKMDSVPELF
GPQRNCVQIL RRYGVDVLDS QVAGRNLQDF LEEVPMTWGT VVKKTFKTKE DILPMQMASV
DSLKVDLDQF YLSIREFRGD FRANAPFKFD GECSEAFSNI DSYASKLDGL EVQIEKFREL
EDLFELQPTV YPEVGETRSE IKQLIHLWEF KQSVNKVYEG WRKLLWKDVY TVDLEDQNKR
LRKELKEKGN SYSSMKGWQV YRDIDELMVV MATVLPLVHD LHSDAIRARH WAALARVCNV
KTVDPADPKF TLHDMLMLKL HTHKEEIDDI VETAMKELKI EKKLTEIESV WSTMELNYSA
HKDTETFVPR PSEEVVESME AHQMELQGIY GMGKFMEYFK DRVVQWQSDL RTVDDTLRMW
ITVARAWASL ESIFLASADI RSQLPEDTKR FEGIDSEFKE LMKEAVLEVN CVRVCSIEGR
FESLKGMQEK LEMCQKSLHE YLDIKKKIFP RFYFVSSVAL LDMLANGTNP TKIMPYLGDC
YDALENLKFV TQEDGKQSDN IVDTMIAKDG EEVPLLEQFT MEGEVEAYLN RLTESMRTSL
KVILSDAVEK AVNWEIDTPR HEWLFNYPAQ LCITGTQIYW TDETHLALEE YEGGQEDSVK
RYLQTCNNRL SALIQLVLGE LSSANRTKII SLITMDVHSR DVVDRLVTQK TEGPNAFSWQ
QQLRFEWEQL TMDVNVKICD FSCKYFYEWV GNTGRLVITP LTDRCYITLT MALKLYLGGA
PAGPAGTGKT ETTKDLARAL AIPCYVFNCS DQMNFQSIAD IFRGLAQTGA WGCFDEFNRI
PIEVLSVVAT QVKTIQDAIV KYSRPENRDP EFQSVPAGTP PTKVGYFDFM GDTISLIPTC
GFWITMNPGY AGRTELPENL KALFRSCAMI RPDMKLIQEN MLMAEGFQAA RALSVKFNTL
YELSAALLSK QPHYDWGLRA VKSVLRVAGG MKRANPTLDE NQVLMRALRD FNTPKMPIHD
IPIFLRLVND LFMGITVDSK VDEDLKAKIV RVAKERGLQY DEMFVNKTCN FQELLDVRHS
VMLLGPAGCA KTTIWKTLQG AHNLDKPKPT CVAETVNPKS VTGDELYGYM TLAKDWKDGV
LSIIMRGMSK NFADQGFHYY QSYKWVVLDG DIDAVWIESM NTVMDDNKVL TLVSNERVPL
SSAMRMVFEI NSLKNATPAT VSRAGILFIN EVDVGWRPLV ETWVQGRENA TERNNLPSLF
DRYVDALVEM TRRGYKEVTS VRLINKVSTI LYLLEGLLPL VPEGKLTPET IEMIFAFSAI
WAFGGPMNVE KSGDYRKKFS EDFAVTFGAK FPNEGSCFDY FYDPKLGEHV QWQSLVPAHS
PVPIGTRSGQ TPFNELCVET VETVRITYLL DKLVKNGKYA MLVGNAGTGK TEIIKNYLGS
LDKDTDGIVS KSIVMSYYTS SFTLQNELEG YIDKRSGNIF GPPMGKKMVF FIDDMNLPYV
ETYGTQNSIA LLTQHMQYGS IFDRTDLGMR KNLNDIQYIA AMNPTAGSFE ICERCQRHFA
TLAIAMPSQS DLNTIFTSLF GGHLGSFQPS MQELTGKIVE TAIQVHETVC TKFLPSAVRF
MYNWSMRELA NIFQGCCLSK GDYYIKPIML ARLFTHESQR VYADRLVTEE EVGVFNGFFT
EIVRKNLGST SIDTDALFEP NNVFTNFVST TDGSYLPVPS MEKLKSVLDS KLVEYNESNA
IMDLVLFEQA ILHVTRINRI IQNPGGNAML IGVGGSGKQS LCRLAAFIGD FEVRQIAVTS
NSSVEDLKEE LRSIYMSAGV RGNPIVFLMT DSQIINEQFL VYINGIITSG WIPDLFSKEE
IDNIIGSVSN QAKSASVPDT PEARINFFVS NVKRNLHVVL AFSPVGDAFR VRARRFPGLV
NSTVIDQFHP WPRDALVSVA ERFLEEVEMS GPSDIKKNLA MHMAEEHLSV ANMSRHFLET
QRRYNYVTPK SFLELISFFK YLIGNKQTDL QRLIDRLDVG LSTLRKTSQD VTELQKDLKI
TMEKVEEKKV ATDKLINEMS VQQADAQVQE EAAQIEATKA NEESEKAMKI ENEAEQELSE
AKPAMEAAAA AVDCLSKAML TELKGLSKPP AGVDKVTNAC LILIEKEYNP KKQTWNRAKQ
MMQNVDAFKG KLSEFRGEDI TEQEIGLVKQ YIEDPSFTPE KMTSKSAAAA NLCSWVVNVY
NFNRIYVKVK PLMDSLQAAR ESKANAIASL EAAQQKVAEV QSQLAILNEN YEEAVREKQE
VEDQAAALST RADLAQRLVG GLSSENVRWG QEIEHLKSNA LTLVGDCMLA AGFVSYVGAF
DKELREDLWK IQWSADLKSR NIPMTEGSDP LGVLSNEGNS SKMVSEGLPS DRISLENGAI
LTNCKRWPLL IDPQMQGIKW LKRKEEGNLD VIQLTQKNWL KVLENAITNG RCVIIENIGT
DIDSTLDPVL SRSIYKKGRS LYLKLGGEEV EYDPAFQLYL QTKLSNPHYK PEVAAQCTLI
NFIATEKGLE DQLLAKVVEL ERQDLEEKSR ALTAAAINYE IQLVELEDEL LERLANAPED
ILSDVPLIEG LEATKKTAQE ISEAVESGKI TQKEVEEARE AYRPQAAEGA MLYFLLTKLC
VIDHMYQYSL DSFLTFFEKS VHKTPAKDNL QDRVISLRDS LRISIFTWVS RGLFERHKLI
FLAQLTFNLM KRGIIGNEHW NEAQFQFLIR APTKSTDQNP LSWLPDTAWA SAAALTDLEE
FNKFTGDLVE AAPRFREWFN AIAPEVEKLP LDWAGLDRRP FQKMLVVRCL RPDRMASALT
SFIGNTLPEG RSYIECDSTL NSLEILESCL ADSTPKTPIY FILSPGANVV ADLDKKAAAN
GLQKSVSYHN VSMGQGQDAV AMSCLETAHR NGHWVILNNV HLMPKWLVEL EKKLDEYAAE
GSHEKFRVFL TSDPSDAIPI GILNRCIKLT NEPPAGLKAN LKRAWCFFPK EYIEEADSKT
RSILFGLCHF HSVLMERKQF GPMGYNMKYP FSIGDLRDSA TCLQNYMDNS GGGKIPWQDL
KYIFGEIMYG GHIVNDFDRL LANEYLNFYM KDELLDETEM YPFAEDEKGV SFMSPTPTSF
EKYIEHIDKN MSGDTPIAFG LHPNAEIDFR TQQSNTMFKT LIELQPREVS SGKGVSTPQE
MAGANANELL EKFGEKTFDV EELVRSLDEI GPYQNVFIQE MDVMNVLLAE IKRSIKELQL
GFDGELTMSE PMEDLMMALY MDRVPLTWAK KAWPSMKSLG SWVKNLSDRI LQLEEWMNNP
SEIPKVTWIS GLVNPTSFLT AICQVTAQKN QWELDKLVTF TRVTKMMTVD EVDRHSRDGA
FIIGLNLQGA SWDLVGSQIE KSKPKEMFCP MPVINVKAVT KEKANVGGVY HCPTYMTEQR
GPTYYWSAQL KTTSPPSRWV LAGVAMVGEC
//
