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Database: UniProt
Entry: B8C2N9_THAPS
LinkDB: B8C2N9_THAPS
Original site: B8C2N9_THAPS 
ID   B8C2N9_THAPS            Unreviewed;       813 AA.
AC   B8C2N9;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   07-JUN-2017, entry version 43.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=THAPSDRAFT_40728 {ECO:0000313|EMBL:EED92420.1};
OS   Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC   Eukaryota; Stramenopiles; Bacillariophyta; Coscinodiscophyceae;
OC   Thalassiosirophycidae; Thalassiosirales; Thalassiosiraceae;
OC   Thalassiosira.
OX   NCBI_TaxID=35128 {ECO:0000313|Proteomes:UP000001449};
RN   [1] {ECO:0000313|EMBL:EED92420.1, ECO:0000313|Proteomes:UP000001449}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP1335 {ECO:0000313|EMBL:EED92420.1,
RC   ECO:0000313|Proteomes:UP000001449};
RX   PubMed=15459382; DOI=10.1126/science.1101156;
RA   Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA   Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M.,
RA   Brzezinski M.A., Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S.,
RA   Detter J.C., Glavina T., Goodstein D., Hadi M.Z., Hellsten U.,
RA   Hildebrand M., Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N.,
RA   Lau W.W., Lane T.W., Larimer F.W., Lippmeier J.C., Lucas S.,
RA   Medina M., Montsant A., Obornik M., Parker M.S., Palenik B.,
RA   Pazour G.J., Richardson P.M., Rynearson T.A., Saito M.A.,
RA   Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A., Wilkerson F.P.,
RA   Rokhsar D.S.;
RT   "The genome of the diatom Thalassiosira pseudonana: ecology,
RT   evolution, and metabolism.";
RL   Science 306:79-86(2004).
RN   [2] {ECO:0000313|EMBL:EED92420.1, ECO:0000313|Proteomes:UP000001449}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP1335 {ECO:0000313|EMBL:EED92420.1,
RC   ECO:0000313|Proteomes:UP000001449};
RX   PubMed=18923393; DOI=10.1038/nature07410;
RA   Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA   Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E.,
RA   Salamov A., Vandepoele K., Beszteri B., Gruber A., Heijde M.,
RA   Katinka M., Mock T., Valentin K., Verret F., Berges J.A., Brownlee C.,
RA   Cadoret J.P., Chiovitti A., Choi C.J., Coesel S., De Martino A.,
RA   Detter J.C., Durkin C., Falciatore A., Fournet J., Haruta M.,
RA   Huysman M.J., Jenkins B.D., Jiroutova K., Jorgensen R.E., Joubert Y.,
RA   Kaplan A., Kroger N., Kroth P.G., La Roche J., Lindquist E.,
RA   Lommer M., Martin-Jezequel V., Lopez P.J., Lucas S., Mangogna M.,
RA   McGinnis K., Medlin L.K., Montsant A., Oudot-Le Secq M.P., Napoli C.,
RA   Obornik M., Parker M.S., Petit J.L., Porcel B.M., Poulsen N.,
RA   Robison M., Rychlewski L., Rynearson T.A., Schmutz J., Shapiro H.,
RA   Siaut M., Stanley M., Sussman M.R., Taylor A.R., Vardi A.,
RA   von Dassow P., Vyverman W., Willis A., Wyrwicz L.S., Rokhsar D.S.,
RA   Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA   Grigoriev I.V.;
RT   "The Phaeodactylum genome reveals the evolutionary history of diatom
RT   genomes.";
RL   Nature 456:239-244(2008).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CM000642; EED92420.1; -; Genomic_DNA.
DR   RefSeq; XP_002290668.1; XM_002290632.1.
DR   STRING; 35128.Thaps40728; -.
DR   EnsemblProtists; EED92420; EED92420; THAPSDRAFT_40728.
DR   GeneID; 7449626; -.
DR   KEGG; tps:THAPSDRAFT_40728; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; B8C2N9; -.
DR   KO; K02154; -.
DR   Proteomes; UP000001449; Chromosome 5.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001449};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Hydrolase {ECO:0000313|EMBL:EED92420.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001449};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    418    441       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    461    480       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    546    568       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    575    599       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    640    664       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    747    771       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       96    123       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   813 AA;  92413 MW;  6E57BDE63967117F CRC64;
     MSRWFRSEHM EYISLIVNED AAHDCLADLG KLSAIQFTDL NPDLTPFQRR YVSYVRRCDE
     LERKLRFFGN ECDNFGLKLD TAGDIDTFLE SPTALLESLE VELEGYESQL KELNAYSEKL
     TREYNEKVEL QEVLEKARRF FMTDAPRLAV SELSGGRKPG SGSNQGLLAG AHDAEARDMD
     MRFSSITGVV STEEKVRFER MIFRATRGNC YVRFAPIKQP ITDPESGSLI EKCVFIVFFK
     SLSIETKLKK ICDAFFAHRY SLPDMDDAPA VDRMLTENAQ ELVDSRTVLL KNQDTRFRLC
     QMLAQHTERW TWIVLREKAV YHTLNMFKAD VSGMLRGEGW VISESFEDIR MSVNRAHSEM
     DHNMPSHVDQ VPKPWPTPPT HFTTNKFTYG YQEFVNTYGI PRYREANPAL FTAATFPFLF
     GVMYGDIGHG LFLFCAGLYL LWNEDKNDKA KLDEMTGGLH AGRYMITMMG FFAVYAGLVY
     NDCFSLGLNL FGSRWAFANG EPEEGDVAEM TGQYGDGDSV YPFGLDPMWH VAQNELLFFN
     SFKMKLSVIF GIFQMFSGTC LKGINAIYFG KRLDFLFEFL PMVAFACSLF VYMVVLIFMK
     WSINWNSRML SATYGCQPPN LITALINIAL SPGVVDEPMY YGQAGIQNIL LAIAGISVPV
     LLLAKPYFLS KEAASHAHSA HDDDDDDEEH GFGEIIIHQA IETIEFVLGM VSNTASYLRL
     WALSLAHSEL ATVFWEKAML STLNLNWFAT FIGYGIFAGT TFGVLLMMDV LECFLHALRL
     HWVEFQNKFF HADGIRFAPY SFKQILSDAS AAH
//
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