ID B8C468_THAPS Unreviewed; 1161 AA.
AC B8C468;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=RRM domain-containing protein {ECO:0000259|PROSITE:PS50102};
GN ORFNames=THAPSDRAFT_23218 {ECO:0000313|EMBL:EED91669.1};
OS Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=35128 {ECO:0000313|EMBL:EED91669.1, ECO:0000313|Proteomes:UP000001449};
RN [1] {ECO:0000313|EMBL:EED91669.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED91669.1};
RX PubMed=15459382; DOI=10.1126/science.1101156;
RA Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M., Brzezinski M.A.,
RA Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S., Detter J.C.,
RA Glavina T., Goodstein D., Hadi M.Z., Hellsten U., Hildebrand M.,
RA Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N., Lau W.W., Lane T.W.,
RA Larimer F.W., Lippmeier J.C., Lucas S., Medina M., Montsant A., Obornik M.,
RA Parker M.S., Palenik B., Pazour G.J., Richardson P.M., Rynearson T.A.,
RA Saito M.A., Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A.,
RA Wilkerson F.P., Rokhsar D.S.;
RT "The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and
RT metabolism.";
RL Science 306:79-86(2004).
RN [2] {ECO:0000313|EMBL:EED91669.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED91669.1};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the YIF1 family.
CC {ECO:0000256|ARBA:ARBA00009727}.
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DR EMBL; CM000643; EED91669.1; -; Genomic_DNA.
DR RefSeq; XP_002291562.1; XM_002291526.1.
DR AlphaFoldDB; B8C468; -.
DR STRING; 35128.B8C468; -.
DR PaxDb; 35128-Thaps23218; -.
DR EnsemblProtists; EED91669; EED91669; THAPSDRAFT_23218.
DR GeneID; 7442739; -.
DR KEGG; tps:THAPSDRAFT_23218; -.
DR eggNOG; KOG2476; Eukaryota.
DR HOGENOM; CLU_275282_0_0_1; -.
DR InParanoid; B8C468; -.
DR OMA; HIQCIPV; -.
DR Proteomes; UP000001449; Chromosome 6.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0061632; F:RNA lariat debranching enzyme activator activity; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00590; RRM_SF; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR040194; Cwf19-like.
DR InterPro; IPR006768; Cwf19-like_C_dom-1.
DR InterPro; IPR036265; HIT-like_sf.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR005578; Yif1_fam.
DR PANTHER; PTHR12072; CWF19, CELL CYCLE CONTROL PROTEIN; 1.
DR PANTHER; PTHR12072:SF4; CWF19-LIKE PROTEIN 1; 1.
DR Pfam; PF04677; CwfJ_C_1; 1.
DR Pfam; PF03878; YIF1; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001449};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 503..592
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 117..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..621
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1161 AA; 125239 MW; 9A1AB42A272E923E CRC64;
MSANRAKVLM VGPVNGQLKL LSDKLHSLQK SKAGPFDVCI CCGPFFYQTV HTNTTSSDNG
GDTSNAEDKL LKDAAVDDGA KLVDGTLTFD VPVLFVDEGD GLPEGVKVLS ASSLNEKKKD
EDEIDINDDD EVEEESAAKK EEGAESADNE INVPDGLLRI APNLYQLVGD KSDSKVLDGV
ADIIGLTLPL KDPEAPAPIN PKQQRQHSTS LTVGFLGSKI RLPCTKFEEK SKHTSFLGCD
VLISGEWGQG MSSKKVGALT EEDRSAIIGA ATTVENDGTN APSVESTGDI IGSYDVAELV
AMSRPRYHLA PGPLVPVQKG GDGEDSTTFS LRNRFVASLP YRYPRTSTTT SGEGQHAGRF
LAIGSVVPPA EAKTLGKAFK FIHAVGIVPL AYMDANDREA AMELGSVVNC PYTDESYDVD
AAGTSANIGM NANINVGVGT GGLSEAHARR IAQEDAASRM ASGGEGAFRW QQRGKKRQRD
DDQGGNEEEA KRQAIEEANN ENCSLFLHGL HRDPSIALTM DAIMDAFRPF GCVGVRFPKP
KMNMGHYGQQ ASPPSYAFLD FTTHEEASQC LADLKGEAIV RNVMLTLKWS SSPGGANRRM
PPNTMQPPFN GGIPPPPPPR RNRLTEAEAA DSTTLFLRLP TTDASTFPAD LETVRLFAQT
TMEDELNIGV PMDSPDRVTA ADEPALRVTL RHPNEQTNYG FLEFASHAAA LTTMVSLTGF
DDGGVVSDDK LAVGVAAEGD STKKPISHLQ GVTLYWAKGS SQPKGDNNAN GKNHGLSFNK
QHFPPDSRTD CWFCLASPSC EKHLIVAVRE ECYVAMPKGA VNDFHALIVP VEHGGDGALV
NKKVAPEMDD VKSQLRMHAK TVLQKDLFVF ERCIQTKGGY HTHIQCIPVE ADSGPALQSK
MLEMAIRCGF QLKEITSDLG LNALEDDWSG GYFYAEIPLP GGGNEFRRFI YRAGDAGDGN
NNCGGRKGTV PLQFGREVLA EVMGNPDIAQ WKACVVRGFY EGGYSGYGGG TNNNTGSGGY
NYGGGYSQSQ PTAAPQQQQQ QQQQQQYQQQ QQQQTNPNSM DPTPMNFWNP TTASMAMSAA
NAFASGKGGT GDAQSQVMFG MAESMGKQFL ETGWARAVPG LERSMVALRP YFAVDNGYVK
RKMGRVLFPF MFKDWMRQCI G
//
