ID B8CJ24_SHEPW Unreviewed; 475 AA.
AC B8CJ24;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU000417};
DE EC=2.1.1.37 {ECO:0000256|RuleBase:RU000417};
GN OrderedLocusNames=swp_0839 {ECO:0000313|EMBL:ACJ27650.1};
OS Shewanella piezotolerans (strain WP3 / JCM 13877).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=225849 {ECO:0000313|EMBL:ACJ27650.1, ECO:0000313|Proteomes:UP000000753};
RN [1] {ECO:0000313|EMBL:ACJ27650.1, ECO:0000313|Proteomes:UP000000753}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WP3 / JCM 13877 {ECO:0000313|Proteomes:UP000000753};
RX PubMed=18398463; DOI=10.1371/journal.pone.0001937;
RA Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L.,
RA Bartlett D.H., Yu J., Hu S., Xiao X.;
RT "Environmental adaptation: genomic analysis of the piezotolerant and
RT psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans
RT WP3.";
RL PLoS ONE 3:E1937-E1937(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|ARBA:ARBA00000743,
CC ECO:0000256|RuleBase:RU000417};
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
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DR EMBL; CP000472; ACJ27650.1; -; Genomic_DNA.
DR RefSeq; WP_020911029.1; NC_011566.1.
DR AlphaFoldDB; B8CJ24; -.
DR STRING; 225849.swp_0839; -.
DR REBASE; 19222; M.SpiWPORF839P.
DR KEGG; swp:swp_0839; -.
DR eggNOG; COG0270; Bacteria.
DR HOGENOM; CLU_006958_2_0_6; -.
DR OrthoDB; 9813719at2; -.
DR Proteomes; UP000000753; Chromosome.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR031303; C5_meth_CS.
DR InterPro; IPR041657; HTH_17.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR Pfam; PF12728; HTH_17; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS00095; C5_MTASE_2; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT DOMAIN 6..49
FT /note="Helix-turn-helix"
FT /evidence="ECO:0000259|Pfam:PF12728"
FT ACT_SITE 152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 475 AA; 53583 MW; 73AA0948A8DBF70D CRC64;
MSTEISIKDA AKQLNISEQR VRTLCRQGEL ESRKFGNSWI INAESIDKYG LRTAHMVAED
HPAYNVNEKC KKPIALSFFS GAMGLDLGIE KSGFDVRLAC EVDKYCRQTI ALNKPDTALL
TDINKYSANE VRLAAGLGKD EEIDLIMGGP PCQAFSTAGK RKGLNDERGN VFLKYIDLAL
ELRPKYFVIE NVRGLLSCPM EHRPHEKRGD DYPELGLDEL KGGALNFIIN RLENSGYSYS
FNLYNSANFG TPQIRERVII ICSRDGVKPP YLVPTHSEFG SDGLQKWNTV KKAISNLTSH
DHLTFPEKRL KYYRMLSAGQ NWKNLPIETQ KEAMGKSFYS GGGKTGFLRR LGWDKPSPTL
VTHPAMPATD LAHPVEDRPL SVQEYKRIQE FPDSWDLAGP IIQQYKQVGN AVPISMGNAV
GKLIMNLLKG NEIPSFNNFK YSRYKNTSDK EWKEQFSKQV LKHKESTEQK ELGFG
//
