ID B8CWP4_HALOH Unreviewed; 603 AA.
AC B8CWP4;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 01-MAY-2013, entry version 32.
DE RecName: Full=L-fucose isomerase;
DE EC=5.3.1.25;
DE AltName: Full=6-deoxy-L-galactose isomerase;
DE AltName: Full=FucIase;
GN Name=fucI; OrderedLocusNames=Hore_09570;
OS Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562).
OC Bacteria; Firmicutes; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC Halothermothrix.
OX NCBI_TaxID=373903;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H 168 / OCM 544 / DSM 9562;
RX PubMed=19145256; DOI=10.1371/journal.pone.0004192;
RA Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D.,
RA Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.;
RT "Genome analysis of the anaerobic thermohalophilic bacterium
RT Halothermothrix orenii.";
RL PLoS ONE 4:E4192-E4192(2009).
CC -!- FUNCTION: Converts the aldose L-fucose into the corresponding
CC ketose L-fuculose (By similarity).
CC -!- CATALYTIC ACTIVITY: L-fucose = L-fuculose.
CC -!- COFACTOR: Manganese (By similarity).
CC -!- PATHWAY: Carbohydrate degradation; L-fucose degradation; L-
CC lactaldehyde and glycerone phosphate from L-fucose: step 1/3.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the L-fucose isomerase family.
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DR EMBL; CP001098; ACL69713.1; -; Genomic_DNA.
DR RefSeq; YP_002508708.1; NC_011899.1.
DR ProteinModelPortal; B8CWP4; -.
DR SMR; B8CWP4; 18-602.
DR STRING; 373903.Hore_09570; -.
DR EnsemblBacteria; ACL69713; ACL69713; Hore_09570.
DR GeneID; 7313450; -.
DR KEGG; hor:Hore_09570; -.
DR PATRIC; 22101302; VBIHalOre56292_1017.
DR eggNOG; COG2407; -.
DR HOGENOM; HOG000249674; -.
DR KO; K01818; -.
DR OMA; KIGIRPT; -.
DR ProtClustDB; PRK10991; -.
DR BioCyc; HORE373903:GHB1-1002-MONOMER; -.
DR UniPathway; UPA00563; UER00624.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008736; F:L-fucose isomerase activity; IEA:HAMAP.
DR GO; GO:0030145; F:manganese ion binding; IEA:HAMAP.
DR GO; GO:0019317; P:fucose catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.14.10; -; 1.
DR Gene3D; 3.40.275.10; -; 1.
DR Gene3D; 3.40.50.1070; -; 1.
DR HAMAP; MF_01254; Fucose_iso; 1; -.
DR InterPro; IPR004216; Fuc/Ara_isomerase_C.
DR InterPro; IPR015888; Fuc_isomerase_C.
DR InterPro; IPR012888; Fucose_iso_N1.
DR InterPro; IPR005763; Fucose_isomerase.
DR InterPro; IPR009015; Fucose_isomerase_N/cen.
DR InterPro; IPR012889; Fucose_isomerase_N2.
DR Pfam; PF02952; Fucose_iso_C; 1.
DR Pfam; PF07881; Fucose_iso_N1; 1.
DR Pfam; PF07882; Fucose_iso_N2; 1.
DR SUPFAM; SSF50443; Fuc_isomerase_C; 1.
DR SUPFAM; SSF53743; Fuc_isomerase_N; 1.
DR TIGRFAMs; TIGR01089; fucI; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW Fucose metabolism; Isomerase; Manganese; Metal-binding.
FT ACT_SITE 350 350 Proton acceptor (By similarity).
FT ACT_SITE 374 374 Proton acceptor (By similarity).
FT METAL 350 350 Manganese (By similarity).
FT METAL 374 374 Manganese (By similarity).
FT METAL 540 540 Manganese (By similarity).
SQ SEQUENCE 603 AA; 66925 MW; B2D8F24DFF7A2DAF CRC64;
MSNKTNLKIN KQHRLRGNLP KIGIRPAIDG RRKGIRESLE GQTMGMAKAV ANFLEENLKY
PNGTPVECVI ADTCIGGVAE AAATAEKFSR EGVGVSITVS PCWCYGSETM DMNPLIPKAI
WGFNGTERPG AVYLAALKAA HDQKGLPIFP IYGRQVQDAD DRSIPEDVQE KMLRFAKAGL
AVAIMRGKSY LSMGSVSMGI AGSMVNEDFF QEYLGMRNEY VDMSEFIRRM EEEIYDKAEF
KRAMKWVKEN CNEGKDNNPP QVQHSRETKD EEWETVVKMT LIARDLMVGN PKLAEMGYGE
EAMGHNAIAA GFQGQRQWTD HFPNGDFMEA ILNSSFDWNG LREPFIMATE NDTLNGVSML
FGHLLTNTAQ IFADVRTYWS PESVKRVTDK ELTGRAQNGI IHLINSGSAT LDGTGQQTKN
GRPVMKPFWE ISSEEVEACL EATSWRPAML DYFRGGGFSS NYLTKGGMPL TMIRINIIKG
LGPVLQIAEG YSVDLPEDVH RILDQRTDPT WPTTWFAPIL TGKGAFKDVY SVMNRWGANH
AAVSYGHIGG DLITLAAMLR IPVAMHNVSE DKIFRPSAWD GFGTNDLEGA DYRACKTFGP
LYG
//
