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Database: UniProt
Entry: B8CWP4_HALOH
LinkDB: B8CWP4_HALOH
Original site: B8CWP4_HALOH 
ID   B8CWP4_HALOH            Unreviewed;       603 AA.
AC   B8CWP4;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   19-MAR-2014, entry version 36.
DE   RecName: Full=L-fucose isomerase;
DE            Short=FucIase;
DE            EC=5.3.1.25;
DE   AltName: Full=6-deoxy-L-galactose isomerase;
GN   Name=fucI; OrderedLocusNames=Hore_09570;
OS   Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562).
OC   Bacteria; Firmicutes; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC   Halothermothrix.
OX   NCBI_TaxID=373903;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H 168 / OCM 544 / DSM 9562;
RX   PubMed=19145256; DOI=10.1371/journal.pone.0004192;
RA   Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D.,
RA   Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.;
RT   "Genome analysis of the anaerobic thermohalophilic bacterium
RT   Halothermothrix orenii.";
RL   PLoS ONE 4:E4192-E4192(2009).
CC   -!- FUNCTION: Converts the aldose L-fucose into the corresponding
CC       ketose L-fuculose (By similarity).
CC   -!- CATALYTIC ACTIVITY: L-fucopyranose = L-fuculose.
CC   -!- COFACTOR: Manganese (By similarity).
CC   -!- PATHWAY: Carbohydrate degradation; L-fucose degradation; L-
CC       lactaldehyde and glycerone phosphate from L-fucose: step 1/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the L-fucose isomerase family.
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DR   EMBL; CP001098; ACL69713.1; -; Genomic_DNA.
DR   RefSeq; YP_002508708.1; NC_011899.1.
DR   ProteinModelPortal; B8CWP4; -.
DR   SMR; B8CWP4; 18-602.
DR   STRING; 373903.Hore_09570; -.
DR   EnsemblBacteria; ACL69713; ACL69713; Hore_09570.
DR   GeneID; 7313450; -.
DR   KEGG; hor:Hore_09570; -.
DR   PATRIC; 22101302; VBIHalOre56292_1017.
DR   eggNOG; COG2407; -.
DR   HOGENOM; HOG000249674; -.
DR   KO; K01818; -.
DR   OMA; KIGIRPT; -.
DR   OrthoDB; EOG6FJNCF; -.
DR   ProtClustDB; PRK10991; -.
DR   BioCyc; HORE373903:GHB1-1002-MONOMER; -.
DR   UniPathway; UPA00563; UER00624.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008736; F:L-fucose isomerase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0019317; P:fucose catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.14.10; -; 1.
DR   Gene3D; 3.40.275.10; -; 1.
DR   Gene3D; 3.40.50.1070; -; 1.
DR   HAMAP; MF_01254; Fucose_iso; 1.
DR   InterPro; IPR004216; Fuc/Ara_isomerase_C.
DR   InterPro; IPR015888; Fuc_isomerase_C.
DR   InterPro; IPR012888; Fucose_iso_N1.
DR   InterPro; IPR005763; Fucose_isomerase.
DR   InterPro; IPR009015; Fucose_isomerase_N/cen.
DR   InterPro; IPR012889; Fucose_isomerase_N2.
DR   Pfam; PF02952; Fucose_iso_C; 1.
DR   Pfam; PF07881; Fucose_iso_N1; 1.
DR   Pfam; PF07882; Fucose_iso_N2; 1.
DR   SUPFAM; SSF50443; SSF50443; 1.
DR   SUPFAM; SSF53743; SSF53743; 1.
DR   TIGRFAMs; TIGR01089; fucI; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW   Fucose metabolism; Isomerase; Manganese; Metal-binding.
FT   ACT_SITE    350    350       Proton acceptor (By similarity).
FT   ACT_SITE    374    374       Proton acceptor (By similarity).
FT   METAL       350    350       Manganese (By similarity).
FT   METAL       374    374       Manganese (By similarity).
FT   METAL       540    540       Manganese (By similarity).
SQ   SEQUENCE   603 AA;  66925 MW;  B2D8F24DFF7A2DAF CRC64;
     MSNKTNLKIN KQHRLRGNLP KIGIRPAIDG RRKGIRESLE GQTMGMAKAV ANFLEENLKY
     PNGTPVECVI ADTCIGGVAE AAATAEKFSR EGVGVSITVS PCWCYGSETM DMNPLIPKAI
     WGFNGTERPG AVYLAALKAA HDQKGLPIFP IYGRQVQDAD DRSIPEDVQE KMLRFAKAGL
     AVAIMRGKSY LSMGSVSMGI AGSMVNEDFF QEYLGMRNEY VDMSEFIRRM EEEIYDKAEF
     KRAMKWVKEN CNEGKDNNPP QVQHSRETKD EEWETVVKMT LIARDLMVGN PKLAEMGYGE
     EAMGHNAIAA GFQGQRQWTD HFPNGDFMEA ILNSSFDWNG LREPFIMATE NDTLNGVSML
     FGHLLTNTAQ IFADVRTYWS PESVKRVTDK ELTGRAQNGI IHLINSGSAT LDGTGQQTKN
     GRPVMKPFWE ISSEEVEACL EATSWRPAML DYFRGGGFSS NYLTKGGMPL TMIRINIIKG
     LGPVLQIAEG YSVDLPEDVH RILDQRTDPT WPTTWFAPIL TGKGAFKDVY SVMNRWGANH
     AAVSYGHIGG DLITLAAMLR IPVAMHNVSE DKIFRPSAWD GFGTNDLEGA DYRACKTFGP
     LYG
//
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