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Database: UniProt
Entry: B8DIL5
LinkDB: B8DIL5
Original site: B8DIL5 
ID   RF3_DESVM               Reviewed;         529 AA.
AC   B8DIL5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   01-OCT-2014, entry version 39.
DE   RecName: Full=Peptide chain release factor 3 {ECO:0000255|HAMAP-Rule:MF_00072};
DE            Short=RF-3 {ECO:0000255|HAMAP-Rule:MF_00072};
GN   Name=prfC {ECO:0000255|HAMAP-Rule:MF_00072};
GN   OrderedLocusNames=DvMF_2372;
OS   Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Miyazaki F / DSM 19637;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Hazen T.C., Richardson P.;
RT   "Complete sequence of Desulfovibrio vulgaris str. 'Miyazaki F'.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Increases the formation of ribosomal termination
CC       complexes and stimulates activities of RF-1 and RF-2. It binds
CC       guanine nucleotides and has strong preference for UGA stop codons.
CC       It may interact directly with the ribosome. The stimulation of RF-
CC       1 and RF-2 is significantly reduced by GTP and GDP, but not by
CC       GMP. {ECO:0000255|HAMAP-Rule:MF_00072}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00072}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. PrfC
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00072}.
CC   -!- SIMILARITY: Contains 1 tr-type G (guanine nucleotide-binding)
CC       domain. {ECO:0000305}.
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DR   EMBL; CP001197; ACL09313.1; -; Genomic_DNA.
DR   RefSeq; WP_015946005.1; NC_011769.1.
DR   RefSeq; YP_002436781.1; NC_011769.1.
DR   PDB; 3VQT; X-ray; 1.80 A; A/B/C/D=1-529.
DR   PDB; 3VR1; X-ray; 3.00 A; A/B/C/D=1-529.
DR   PDBsum; 3VQT; -.
DR   PDBsum; 3VR1; -.
DR   ProteinModelPortal; B8DIL5; -.
DR   SMR; B8DIL5; 5-527.
DR   STRING; 883.DvMF_2372; -.
DR   EnsemblBacteria; ACL09313; ACL09313; DvMF_2372.
DR   GeneID; 7174306; -.
DR   KEGG; dvm:DvMF_2372; -.
DR   PATRIC; 21775133; VBIDesVul86729_2571.
DR   eggNOG; COG4108; -.
DR   HOGENOM; HOG000236725; -.
DR   KO; K02837; -.
DR   OMA; WMEMERE; -.
DR   OrthoDB; EOG6677Q1; -.
DR   BioCyc; DVUL883:GCJ5-2440-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006449; P:regulation of translational termination; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00072; Rel_fac_3; 1.
DR   InterPro; IPR000795; EF_GTP-bd_dom.
DR   InterPro; IPR009022; EFG_III-V.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004548; PrfC.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR009000; Transl_B-barrel.
DR   InterPro; IPR004161; Transl_elong_EFTu/EF1A_2.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF03144; GTP_EFTU_D2; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54980; SSF54980; 1.
DR   TIGRFAMs; TIGR00503; prfC; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Cytoplasm; GTP-binding;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN         1    529       Peptide chain release factor 3.
FT                                /FTId=PRO_1000193520.
FT   DOMAIN       10    278       tr-type G.
FT   NP_BIND      19     26       GTP. {ECO:0000255|HAMAP-Rule:MF_00072}.
FT   NP_BIND      87     91       GTP. {ECO:0000255|HAMAP-Rule:MF_00072}.
FT   NP_BIND     141    144       GTP. {ECO:0000255|HAMAP-Rule:MF_00072}.
FT   HELIX         4     10
FT   STRAND       12     18
FT   HELIX        25     35
FT   HELIX        39     47
FT   HELIX        56     62
FT   TURN         70     72
FT   STRAND       73     78
FT   STRAND       81     86
FT   HELIX        91     93
FT   HELIX        96    103
FT   STRAND      106    113
FT   TURN        114    116
FT   HELIX       120    131
FT   STRAND      136    141
FT   HELIX       150    161
FT   STRAND      163    173
FT   HELIX       175    177
FT   STRAND      180    183
FT   TURN        184    187
FT   STRAND      188    191
FT   HELIX       213    218
FT   HELIX       219    221
FT   HELIX       222    235
FT   HELIX       241    245
FT   STRAND      248    254
FT   HELIX       257    259
FT   HELIX       263    273
FT   STRAND      280    287
FT   STRAND      295    302
FT   STRAND      313    321
FT   STRAND      328    331
FT   TURN        332    335
FT   STRAND      336    339
FT   STRAND      362    366
FT   STRAND      376    382
FT   STRAND      390    392
FT   STRAND      395    403
FT   HELIX       405    407
FT   HELIX       408    420
FT   STRAND      423    432
FT   STRAND      436    441
FT   HELIX       443    456
FT   STRAND      460    464
FT   STRAND      469    474
FT   HELIX       478    487
FT   HELIX       489    491
FT   STRAND      492    495
FT   STRAND      500    506
FT   HELIX       507    516
FT   STRAND      520    527
SQ   SEQUENCE   529 AA;  59251 MW;  34CD14538609B699 CRC64;
     MSSRLEREAA RRRTFAIISH PDAGKTTLTE KLLLFGGAIQ MAGSVKARKA ARHATSDWMA
     MERERGISVT TSVMQFPYRD RVVNLLDTPG HQDFSEDTYR VLTAVDSALV VIDAAKGVEA
     QTRKLMDVCR MRATPVMTFV NKMDREALHP LDVMADIEQH LQIECAPMTW PIGMGSSFKG
     TYDLLHKQLH LFSATHGGRI QSGIVIHGAD DPQLDEYLGD QAEQLRMDLA LLEEAGTPFD
     EERYLKGELT PVFFGSAINN FGVREMLDMF VEFAPGPQPR PAATRVVEPG EEAFTGVVFK
     IQANMDKAHR DRMAFLRICS GTFTRGMRLK HHRTGKDVTV ANATIFMAQD RTGVEEAFPG
     DIIGIPNHGT IKIGDTFTES KEVLKFVGIP NFAPEHFRRV RLKNPLKAKQ LQKGLEQLAE
     EGAVQLFRPL VNNDYILGAV GVLQFDVIVA RLADEYGVDA VYEGVSTHTA RWVYCEDKKI
     FADFQDYHRG ELAVDAEGAL AYLAPNPWRL ESAMERYPKV EFRTTREIS
//
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