GenomeNet

Database: UniProt
Entry: B8DN02
LinkDB: B8DN02
Original site: B8DN02 
ID   GSA_DESVM               Reviewed;         425 AA.
AC   B8DN02;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   14-MAY-2014, entry version 38.
DE   RecName: Full=Glutamate-1-semialdehyde 2,1-aminomutase;
DE            Short=GSA;
DE            EC=5.4.3.8;
DE   AltName: Full=Glutamate-1-semialdehyde aminotransferase;
DE            Short=GSA-AT;
GN   Name=hemL; OrderedLocusNames=DvMF_2502;
OS   Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Miyazaki F / DSM 19637;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Hazen T.C., Richardson P.;
RT   "Complete sequence of Desulfovibrio vulgaris str. 'Miyazaki F'.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: (S)-4-amino-5-oxopentanoate = 5-
CC       aminolevulinate.
CC   -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-
CC       IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step
CC       2/2.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC       aminotransferase family. HemL subfamily.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP001197; ACL09442.1; -; Genomic_DNA.
DR   RefSeq; YP_002436910.1; NC_011769.1.
DR   ProteinModelPortal; B8DN02; -.
DR   STRING; 883.DvMF_2502; -.
DR   PRIDE; B8DN02; -.
DR   EnsemblBacteria; ACL09442; ACL09442; DvMF_2502.
DR   GeneID; 7174438; -.
DR   KEGG; dvm:DvMF_2502; -.
DR   PATRIC; 21775425; VBIDesVul86729_2715.
DR   eggNOG; COG0001; -.
DR   HOGENOM; HOG000020210; -.
DR   KO; K01845; -.
DR   OMA; AKHTIVL; -.
DR   OrthoDB; EOG6QVRHN; -.
DR   BioCyc; DVUL883:GCJ5-2572-MONOMER; -.
DR   UniPathway; UPA00251; UER00317.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042286; F:glutamate-1-semialdehyde 2,1-aminomutase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0008483; F:transaminase activity; IEA:InterPro.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 2.
DR   HAMAP; MF_00375; HemL_aminotrans_3; 1.
DR   InterPro; IPR004639; 4pyrrol_synth_GluAld_NH2Trfase.
DR   InterPro; IPR005814; Aminotrans_3.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_major_sub2.
DR   PANTHER; PTHR11986; PTHR11986; 1.
DR   Pfam; PF00202; Aminotran_3; 1.
DR   PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   TIGRFAMs; TIGR00713; hemL; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Isomerase; Porphyrin biosynthesis;
KW   Pyridoxal phosphate.
FT   CHAIN         1    425       Glutamate-1-semialdehyde 2,1-aminomutase.
FT                                /FTId=PRO_1000121878.
FT   MOD_RES     266    266       N6-(pyridoxal phosphate)lysine (By
FT                                similarity).
SQ   SEQUENCE   425 AA;  44474 MW;  CDF88FF73C7FF852 CRC64;
     MDHRSKELFE RAQQLIPGGV NSPVRACLGV DSDPLFVAHA KGSHLTTVDG TSFVDYVQSW
     GPMLLGHAHP VVASAIHAAV DRGTSYGAPC EDEVVLAEAV IDALPGVEMV RMVNSGTEAT
     MSALRLARGV TGRNKVVKFV GCYHGHADAF LASAGSGVAT LSIPGTPGVP EATVRDTLLA
     PYNDLTAVAE LFTLHGKDIA AIIVEPVAGN MGLVLPMNGF LQGLRDLCTE HGALLIFDEV
     ITGFRVNYGG AQKRFDITPD LTTLGKIIGG GLPVGAYGGR ADLMRRIAPC GEVYQAGTLS
     GNPLAMAAGI ATLAELKKSD YDALEARVAA LATELQAILA AKGVPVRVNT IASMFTVFFT
     DQPVTDFASA KTANAALYTS YYKQMRDKGI YLAPSPFEAA MVSFAHTDAD LAALLDAARA
     ITLSA
//
DBGET integrated database retrieval system