ID B8DU01_BIFA0 Unreviewed; 850 AA.
AC B8DU01;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Protease {ECO:0000313|EMBL:ACL29480.1};
GN Name=clpC {ECO:0000313|EMBL:ACL29480.1};
GN OrderedLocusNames=BLA_1192 {ECO:0000313|EMBL:ACL29480.1};
OS Bifidobacterium animalis subsp. lactis (strain AD011).
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=442563 {ECO:0000313|EMBL:ACL29480.1, ECO:0000313|Proteomes:UP000002456};
RN [1] {ECO:0000313|EMBL:ACL29480.1, ECO:0000313|Proteomes:UP000002456}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AD011 {ECO:0000313|EMBL:ACL29480.1,
RC ECO:0000313|Proteomes:UP000002456};
RX PubMed=19011029; DOI=10.1128/JB.01515-08;
RA Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H.,
RA Kim D.-W., Ji G.E., Park H.-S., Oh T.K.;
RT "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp.
RT lactis AD011.";
RL J. Bacteriol. 191:678-679(2009).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP001213; ACL29480.1; -; Genomic_DNA.
DR RefSeq; WP_004218154.1; NC_011835.1.
DR AlphaFoldDB; B8DU01; -.
DR STRING; 442563.BLA_1192; -.
DR GeneID; 66533018; -.
DR KEGG; bla:BLA_1192; -.
DR PATRIC; fig|442563.4.peg.1254; -.
DR HOGENOM; CLU_005070_4_2_11; -.
DR Proteomes; UP000002456; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:ACL29480.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protease {ECO:0000313|EMBL:ACL29480.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002456};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 2..145
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT DOMAIN 428..463
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 142..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 424..470
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 850 AA; 94226 MW; 091E504604C240D6 CRC64;
MFERFTDRAR RVIVLAQEEA RALQHNYIGT EHLLLGLIRE GDGVAAKALE AKGVTLEDTR
KQVEEMIGKG TAAPTGHIPF TPHAKQVLEL SLREALQLGH SYIGTEHILL GLIREGEGVG
TQVLIKMDVD LSDLRSTTID MIRGNSGNGE GDKGDMANAG SVQDKRSQSG SAILDQFGRN
LTAEAKDGKL DPVIGRSTEI ERVMVVLSRR TKNNPVLIGE PGVGKTAVVE GLAQKIVAGD
VPETLKDKQV YSLDLGSMVA GSRYRGDFEE RLKKVLKEIK TRGDIVLFID EIHTIVGAGS
ADGALGASDM LKPMLARGEL QTIGATTTDE YRKYIEKDAA LERRFQPIQV SEPSIAETIE
ILKGLRARYE NHHHVTITDG ALQSAAELSA RYIQDRNLPD KAIDLIDEAG ARLRIKRLTA
PPELKELDNR IARIAKEKDQ TIKDQQFEKA AELRDKQEKL EAERKEKEKS WREGESDVRM
VVDEDVIAEV ISQSTGIPVF KLTQAESKKL MSMEKELHKR IIGQDEAVSA LSRSIRRTRV
GLKDPKRPAG SFIFAGPTGV GKTELAKALA QFLFDDEDAL IRVDMSEFSE KYAASRLFGA
PPGYVGYEEG GELTEKVRRK PFSVVLFDEI EKAHPDIFNT LLQVLDDGHL TDGQGRKVDF
KNTIIILTTN LGTRDIAKTA NTGFTMGGNT ESSYQRMKDQ VSSELKQQFR PEFLNRLDDI
IVFRQLTEPQ VRQIVDLDVT KINDRLFERH MELDLTDKAK DLLAEKGFDP LLGARPLRRV
IQRDIEDTIS EKILMGDLHD NERVIVDAEG DGILGEFTFR GEPFELPAAG EGDESKDVVP
EPAAAASEAE
//
