ID B8GBU0_CHLAD Unreviewed; 1016 AA.
AC B8GBU0;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Cagg_2019 {ECO:0000313|EMBL:ACL24907.1};
OS Chloroflexus aggregans (strain MD-66 / DSM 9485).
OC Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Chloroflexineae;
OC Chloroflexaceae; Chloroflexus.
OX NCBI_TaxID=326427 {ECO:0000313|EMBL:ACL24907.1, ECO:0000313|Proteomes:UP000002508};
RN [1] {ECO:0000313|Proteomes:UP000002508}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MD-66 / DSM 9485 {ECO:0000313|Proteomes:UP000002508};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Bryant D.A., Richardson P.;
RT "Complete sequence of Chloroflexus aggregans DSM 9485.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP001337; ACL24907.1; -; Genomic_DNA.
DR AlphaFoldDB; B8GBU0; -.
DR STRING; 326427.Cagg_2019; -.
DR KEGG; cag:Cagg_2019; -.
DR eggNOG; COG0784; Bacteria.
DR eggNOG; COG2203; Bacteria.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_294544_0_0_0; -.
DR Proteomes; UP000002508; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00156; REC; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 3.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF13185; GAF_2; 2.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 3.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 3.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACL24907.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACL24907.1}.
FT DOMAIN 659..878
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 896..1010
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 945
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1016 AA; 112216 MW; 8833F27065065F45 CRC64;
MLLVIPRVYN KIMTNQDTPS DQSAVTSPIA TILALSKAVL SSLELPDVLQ RVLVATRDLS
GADVVTIWLL DEQGEWLTSA AILGLEDRPE RERIFRLRVG EGIAGWSVAH RQILQITNPL
HDPRYVPKLD RHPAIILSIP LIVRAQCVGA LSLSRYTVAT PFSQEVIETI SIFADQAAIA
IDNATKAQIL RYATARERIL AHSTESTQAE TLILAELAVV LGVEPLLIST TYDGNLLDHA
GHNVHYDDLN RWRNEGALIT DLRFDGLPAW LVVNQPGRYW SKEDTNLLAF AANQLMRARQ
RAFEQRAHAR AEALHRLVAL TNARIDQASV LDQILAELQR FIPFDSACVF VVHDDEYVRL
IAQRGLRTPV DQVTLFAGPG STIYDLRQVG TARYHPDVQQ LPGWQKVPDS EIIRSWIGVP
LRVDQTTIGF LTIDKWIPNA FTAEDVGTAQ MFGEQVAAVI NNVRLLREAQ ERASQFQVLQ
QFTVRIGAVR DIDQLLDEAT QLLHRTFGYY QVLISVIEHD QLIVRAAYGR LMHCQSSEQV
FPPLPCDVGI SGWVIRHAQP AIVNDVLRDE RYVCHPFLPA TAAEMIVPIL VDERVFGVIT
IESDVRGVFA QSDLDLVTAM AHLIGVTIAN LQHDAELQRA REQLIERDRL RALGELSSGV
AHDFNNLLAS ILGHVQLLLN EYHDPRLQEG LRAIELAAID GAATIKRLQG FAQTSQSTPQ
GAVDLNQVVE ESLALTRPRW RDEAQSRGIV IEVRTDLEPL PIITGDAPAL RELIINLVLN
AIDALPNGGT ITIRTTPAPP EVFGAAGVLL VIQDNGVGID PALHERIFAP FFSTKGVRGT
GMGLAIVRGI VQQHGGRITL ESEPGKGTMF QIWLPVGQPP ELPTSSSQPS PMVPLHILVV
DDETAVRQVL TRILERQGHR VVEATSGEEA LAQYRPGRYA IICTDLGMPG MSGWELASRV
RQIDTTVRIV LVTGWSEQVD PADMQRYGVN AILAKPFTIQ SVQNLIASLV DAAEQV
//
