ID B8GDQ1_METPE Unreviewed; 1064 AA.
AC B8GDQ1;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=Mpal_2104 {ECO:0000313|EMBL:ACL17402.1};
OS Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanoregulaceae; Methanosphaerula.
OX NCBI_TaxID=521011 {ECO:0000313|EMBL:ACL17402.1, ECO:0000313|Proteomes:UP000002457};
RN [1] {ECO:0000313|EMBL:ACL17402.1, ECO:0000313|Proteomes:UP000002457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1556 / DSM 19958 / E1-9c
RC {ECO:0000313|Proteomes:UP000002457};
RX PubMed=26543115; DOI=10.1128/genomea.01280-15;
RA Cadillo-Quiroz H., Browne P., Kyrpides N., Woyke T., Goodwin L., Detter C.,
RA Yavitt J.B., Zinder S.H.;
RT "Complete Genome Sequence of Methanosphaerula palustris E1-9CT, a
RT Hydrogenotrophic Methanogen Isolated from a Minerotrophic Fen Peatland.";
RL Genome Announc. 3:e01280-15(2015).
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
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DR EMBL; CP001338; ACL17402.1; -; Genomic_DNA.
DR RefSeq; WP_012618721.1; NC_011832.1.
DR AlphaFoldDB; B8GDQ1; -.
DR STRING; 521011.Mpal_2104; -.
DR GeneID; 7271582; -.
DR KEGG; mpl:Mpal_2104; -.
DR eggNOG; arCOG00439; Archaea.
DR HOGENOM; CLU_000995_7_2_2; -.
DR OrthoDB; 6747at2157; -.
DR Proteomes; UP000002457; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR006142; INTEIN.
DR InterPro; IPR004042; Intein_endonuc.
DR InterPro; IPR004860; LAGLIDADG_2.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF43; DNA REPLICATION LICENSING FACTOR MCM6; 1.
DR Pfam; PF14528; LAGLIDADG_3; 1.
DR Pfam; PF00493; MCM; 2.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR00379; INTEIN.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF55608; Homing endonucleases; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR PROSITE; PS50051; MCM_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000002457}.
FT DOMAIN 286..421
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT DOMAIN 566..696
FT /note="DOD-type homing endonuclease"
FT /evidence="ECO:0000259|PROSITE:PS50819"
FT DOMAIN 780..851
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 1064 AA; 120496 MW; CE1C40A8E985D7A0 CRC64;
MSGPEDEFAE ISDRVAEWSR FLKTRYKKEL TELLREYPHK RSLVIDYHQV ESFGKPGLRM
ADEILENPGK VIEDLRDAIK TQHVVKTRKN EQIPREINLR FINLPQKICA RDIRSEQINK
MLSVEGILRK TTEVRPRIVE AIFRCPAGHM TRRMQEYGRF IEPEQCGTEG CTFRKLQLMA
KRSRFIDAQK VRIQESPEGL RGGQQPQTLD VDVTDDITGT VAPGDRVVIN GILRSQQRVT
YGTKSTTFDI YLECNSIEVA EKEFEEVNIT EKDEEEIIRL STDPTIYRKI VHSIAPTIYG
NEDVKEAIAL QLFGGITKEM PDGSRLRGDI HVLLIGDPGI AKSQILRYVV NLSPRGIYTS
GQSSTSAGLT ATAVKDEFGD GRWTLEAGAL VLADMGIAAV DEMDKMQKED RSALHEAMEQ
QCYDDQTEIL TEKGWKFFKD LGKNERVASL TQDGFLTYEI PSQHVISDYD GQMYYIKSRQ
VNLAVTPNHN MYVNLNKRAN DWEGFKLIRM DELPINKRMR FKKNAKWQGD TVATHTVPGI
IKFGNQNCKG YETEPIIVKM DDWLEFLGYF LSEGSVQKHW ETGVPYRVNI SQKIPESTEI
IRICLEKLPF NYSYDGANFS INSKQLAGHL VEFGKCHEKY VPAYAKQVPP EQIQILLNAL
VLGDGWTRKT TRQTVYITSS KRLADDVTEL LLKIGWSGNI YCQHHAGDTI KDPRGIETRY
THGIWEVSFI RDGVNEPNIN TNGEKHIQIK PYSGKIYCVE VPEHLLYVRR DGIPVWCGNT
ISVAKAGITA TLKTRCALLG AANPKLGRFD EYADIGEQIN MPPSLLSRFD LIFILTDKPD
HKRDEAIADF IIRSHGVGEL IAQHSRDPIE GVTDEYITQQ LAPVTPDIDA GMLRKYIAYA
KRTCFPILST EAKETLIAYY MKLRDLADSN KPVPVTARQL EALVRLAEAS ARVRLSKSIE
NSDAERVVKI VDTCLRQVAY DAKTGTFDID KVATGISKGK RDMIRMIKDV IRENGDVSGR
AQIQQVIDLV AQQGFGKDEV KKQIDAFLRS GEAMEPKNGV IKLI
//
